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- W2767259805 abstract "Botryllus schlosseri, a colonial marine invertebrate, exhibits three generations of short-lived astogenic modules that continuously grow and die throughout the colony's entire lifespan, within week-long repeating budding cycles (blastogenesis), each consisting of four stages (A-D). At stage D, aging is followed by the complete absorption of adult modules (zooids) via a massive apoptotic process. Here we studied in Botryllus the protein mortalin (HSP70s member), a molecule largely known for its association with aging and proliferation. In-situ hybridization and qPCR assays reveal that mortalin follows the cyclic pattern of blastogenesis. Colonies at blastogenic stage D display the highest mortalin levels, and young modules exhibit elevated mortalin levels compared to old modules. Manipulations of mortalin with the specific allosteric inhibitor MKT-077 has led to a decrease in the modules' growth rate and the development of abnormal somatic/germinal morphologies (primarily in vasculature and in organs such as the endostyle, the stomach and gonads). We therefore propose that mortalin plays a significant role in the astogeny and aging of colonial modules in B. schlosseri, by direct involvement in the regulation of blastogenesis." @default.
- W2767259805 created "2017-11-17" @default.
- W2767259805 creator A5032967381 @default.
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- W2767259805 date "2018-01-01" @default.
- W2767259805 modified "2023-09-26" @default.
- W2767259805 title "Coupling astogenic aging in the colonial tunicate Botryllus schlosseri with the stress protein mortalin" @default.
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- W2767259805 doi "https://doi.org/10.1016/j.ydbio.2017.10.023" @default.
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