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- W2767278919 abstract "Pseudomonas aeruginosa is an important human pathogen, the physiology and virulence of which are under the control of quorum sensing signals. These signals often have dual roles, functioning as toxins to some cells and as oxidative-stress protectors for their producer cells. Hence, their internal and external concentrations should be tightly controlled. In this study, we analyzed the interplay between the multidrug efflux transporters MexEF-OprN and MexG/HI-OpmD in quorum sensing of P. aeruginosa. We found that the two transporters have overlapping substrate specificities but different efficiencies. When overproduced, both MexEF-OprN and MexG/HI-OpmD provide clinical levels of resistance to diverse fluoroquinolones and protect P. aeruginosa against toxic phenazines. However, this similarity is enabled by synergistic interactions with the outer membrane. In hyperporinated cells, MexG/HI-OpmD is saturated by much lower concentrations of fluoroquinolones but is more efficient than MexEF-OprN in efflux of phe..." @default.
- W2767278919 created "2017-11-17" @default.
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- W2767278919 date "2017-11-10" @default.
- W2767278919 modified "2023-09-24" @default.
- W2767278919 title "Kinetic Control of Quorum Sensing in <i>Pseudomonas aeruginosa</i> by Multidrug Efflux Pumps" @default.
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- W2767278919 doi "https://doi.org/10.1021/acsinfecdis.7b00160" @default.
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