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• W2767333485 abstract "New Findings What is the central question of this study ? What are the factors influencing day–night variations in postprandial triglycerides? What is the main finding and its importance ? Rats show low postprandial plasma triglyceride concentrations early in the active period that are attributable to a higher uptake by skeletal muscle and brown adipose tissue. We show that these day–night variations in uptake are driven by the suprachiasmatic nucleus, probably via a Rev‐erbα‐mediated mechanism and independent of locomotor activity. These findings highlight that the suprachiasmatic nucleus has a major role in day–night variations in plasma triglycerides and that disturbances in our biological clock might be an important risk factor contributing to development of postprandial hyperlipidaemia. Energy metabolism follows a diurnal pattern, mainly driven by the suprachiasmatic nucleus (SCN), and disruption of circadian regulation has been linked to metabolic abnormalities. Indeed, epidemiological evidence shows that night work is a risk factor for cardiovascular disease, and postprandial hyperlipidaemia is an important contributor. Therefore, the aim of this work was to investigate the factors that drive day–night variations in postprandial triglycerides (TGs). Intact and SCN‐lesioned male Wistar rats were subjected to an oral fat challenge during the beginning of the rest phase (day) or the beginning of the active phase (night). The plasma TG profile was evaluated and tissue TG uptake assayed. After the fat challenge, intact rats showed lower postprandial plasma TG concentrations early in the night when compared with the day. However, no differences were observed in the rate of intestinal TG secretion between day and night. Instead, there was a higher uptake of TG by skeletal muscle and brown adipose tissue early in the active phase (night) when compared with the rest phase (day), and these variations were abolished in rats bearing bilateral SCN lesions. Rev‐erbα gene expression suggests this as a possible mediator of the mechanism linking the SCN and day–night variations in TG uptake. These findings show that the SCN has a major role in day–night variations in plasma TGs by promoting TG uptake into skeletal muscle and brown adipose tissue. Consequently, disturbance of the biological clock might be an important risk factor contributing to the development of hyperlipidaemia." @default.
• W2767333485 created "2017-11-17" @default.
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• W2767333485 date "2017-11-07" @default.
• W2767333485 modified "2023-10-17" @default.
• W2767333485 title "The suprachiasmatic nucleus drives day-night variations in postprandial triglyceride uptake into skeletal muscle and brown adipose tissue" @default.
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• W2767333485 doi "https://doi.org/10.1113/ep086026" @default.
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