FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767337538> ?p ?o ?g. }

• W2767337538 endingPage "14" @default.
• W2767337538 startingPage "6" @default.
• W2767337538 abstract "Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. A characteristic feature of RA is the presence of anti-citrullinated protein antibodies (ACPA). Since ACPAs are highly specific for RA and are often present before the onset of RA symptoms, they have become valuable diagnostic and prognostic. As a result, several assays for detection of ACPAs exist, which vary in sensitivity and specificity. In this study, we analyzed the reactivity of RA sera to selected peptides by solid-phase immunoassays in order to develop an ACPA assay with improved sensitivity and specificity. ACPA levels were determined with respect to sensitivity and specificity in 332 serum samples using the newly developed peptide panel, which was compared to the commercial assays CCPlus (Eurodiagnostica) and CCP3.1 (Inova Diagnostics). A primary panel (peptides 814, 33062 and 33156) was identified, which obtained a sensitivity of 71%, while the complete peptide panel reacted with 79% of RA sera screened. Total specificities of 89% and 80% were obtained for the primary peptide panel and the complete peptide panel. Sensitivities for the commercial assays ranged between 71% and 76% and specificities between 88% and 90%. These findings indicate that the generated peptide panel is optimal for ACPA detection and able to compete with commercial available assays. Collectively, this study may contribute to characterize autoimmunity towards citrullinated proteins and to the development of new and improved diagnostic assays for detection of ACPA and determination of RA." @default.
• W2767337538 created "2017-11-17" @default.
• W2767337538 creator A5004910716 @default.
• W2767337538 creator A5005677115 @default.
• W2767337538 creator A5013138894 @default.
• W2767337538 creator A5018187678 @default.
• W2767337538 creator A5037132407 @default.
• W2767337538 creator A5043026941 @default.
• W2767337538 creator A5052693500 @default.
• W2767337538 creator A5053356441 @default.
• W2767337538 creator A5072220744 @default.
• W2767337538 creator A5073487081 @default.
• W2767337538 creator A5086180632 @default.
• W2767337538 creator A5087463104 @default.
• W2767337538 date "2018-03-01" @default.
• W2767337538 modified "2023-10-14" @default.
• W2767337538 title "The use of synthetic peptides for detection of anti-citrullinated protein antibodies in rheumatoid arthritis" @default.
• W2767337538 cites W1586192659 @default.
• W2767337538 cites W1964539908 @default.
• W2767337538 cites W1968117909 @default.
• W2767337538 cites W1968304195 @default.
• W2767337538 cites W1971455589 @default.
• W2767337538 cites W1978711157 @default.
• W2767337538 cites W1980024538 @default.
• W2767337538 cites W1988660834 @default.
• W2767337538 cites W1989515097 @default.
• W2767337538 cites W2004208265 @default.
• W2767337538 cites W2008861688 @default.
• W2767337538 cites W2010461377 @default.
• W2767337538 cites W2013573826 @default.
• W2767337538 cites W2015447263 @default.
• W2767337538 cites W2017212166 @default.
• W2767337538 cites W2017236912 @default.
• W2767337538 cites W2024988150 @default.
• W2767337538 cites W2031170496 @default.
• W2767337538 cites W2034839671 @default.
• W2767337538 cites W2052233370 @default.
• W2767337538 cites W2052622082 @default.
• W2767337538 cites W2056242758 @default.
• W2767337538 cites W2080248605 @default.
• W2767337538 cites W2089005643 @default.
• W2767337538 cites W2091156947 @default.
• W2767337538 cites W2099759573 @default.
• W2767337538 cites W2101254888 @default.
• W2767337538 cites W2102570681 @default.
• W2767337538 cites W2104590417 @default.
• W2767337538 cites W2107005433 @default.
• W2767337538 cites W2109578241 @default.
• W2767337538 cites W2116042754 @default.
• W2767337538 cites W2124313950 @default.
• W2767337538 cites W2128952811 @default.
• W2767337538 cites W2136894699 @default.
• W2767337538 cites W2138891799 @default.
• W2767337538 cites W2140410277 @default.
• W2767337538 cites W2141152363 @default.
• W2767337538 cites W2141521401 @default.
• W2767337538 cites W2143010253 @default.
• W2767337538 cites W2143065147 @default.
• W2767337538 cites W2146203649 @default.
• W2767337538 cites W2149768460 @default.
• W2767337538 cites W2152348310 @default.
• W2767337538 cites W2152581671 @default.
• W2767337538 cites W2153299884 @default.
• W2767337538 cites W2166453502 @default.
• W2767337538 cites W2167385753 @default.
• W2767337538 cites W2167539659 @default.
• W2767337538 cites W2235732627 @default.
• W2767337538 cites W2294386623 @default.
• W2767337538 cites W2471946643 @default.
• W2767337538 cites W2562348661 @default.
• W2767337538 cites W2594334114 @default.
• W2767337538 cites W4205579779 @default.
• W2767337538 cites W4210968471 @default.
• W2767337538 cites W4256490618 @default.
• W2767337538 doi "https://doi.org/10.1016/j.jim.2017.11.004" @default.
• W2767337538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29128424" @default.
• W2767337538 hasPublicationYear "2018" @default.
• W2767337538 type Work @default.
• W2767337538 sameAs 2767337538 @default.
• W2767337538 citedByCount "15" @default.
• W2767337538 countsByYear W27673375382018 @default.
• W2767337538 countsByYear W27673375382019 @default.
• W2767337538 countsByYear W27673375382020 @default.
• W2767337538 countsByYear W27673375382021 @default.
• W2767337538 countsByYear W27673375382022 @default.
• W2767337538 countsByYear W27673375382023 @default.
• W2767337538 crossrefType "journal-article" @default.
• W2767337538 hasAuthorship W2767337538A5004910716 @default.
• W2767337538 hasAuthorship W2767337538A5005677115 @default.
• W2767337538 hasAuthorship W2767337538A5013138894 @default.
• W2767337538 hasAuthorship W2767337538A5018187678 @default.
• W2767337538 hasAuthorship W2767337538A5037132407 @default.
• W2767337538 hasAuthorship W2767337538A5043026941 @default.
• W2767337538 hasAuthorship W2767337538A5052693500 @default.
• W2767337538 hasAuthorship W2767337538A5053356441 @default.
• W2767337538 hasAuthorship W2767337538A5072220744 @default.
• W2767337538 hasAuthorship W2767337538A5073487081 @default.
• W2767337538 hasAuthorship W2767337538A5086180632 @default.

• next