Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767358767> ?p ?o ?g. }
- W2767358767 abstract "Renal angiomyolipomas (AML) contain an admixture of clonal tumour cells with features of several different mesenchymal lineages, implying the existence of an unidentified AML neoplastic stem cell. Biallelic inactivation of TSC2 or TSC1 is believed to represent the driving event in these tumours. Here we show that TSC2 knockdown transforms senescence-resistant cultured mouse and human renal epithelial cells into neoplastic stem cells that serially propagate renal AML-like tumours in mice. mTOR inhibitory therapy of mouse AML allografts mimics the clinical responses of human renal AMLs. Deletion of Tsc1 in mouse renal epithelia causes differentiation in vivo into cells expressing characteristic AML markers. Human renal AML and a renal AML cell line express proximal tubule markers. We describe the first mouse models of renal AML and provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells, uncovering an unexpected pathological differentiation plasticity of the proximal tubule." @default.
- W2767358767 created "2017-11-17" @default.
- W2767358767 creator A5006745683 @default.
- W2767358767 creator A5010556487 @default.
- W2767358767 creator A5023387465 @default.
- W2767358767 creator A5029760404 @default.
- W2767358767 creator A5034002118 @default.
- W2767358767 creator A5045696330 @default.
- W2767358767 creator A5046675362 @default.
- W2767358767 creator A5048139572 @default.
- W2767358767 creator A5068920019 @default.
- W2767358767 date "2017-11-13" @default.
- W2767358767 modified "2023-10-17" @default.
- W2767358767 title "Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells" @default.
- W2767358767 cites W1530905865 @default.
- W2767358767 cites W1955674559 @default.
- W2767358767 cites W1976184018 @default.
- W2767358767 cites W1980066502 @default.
- W2767358767 cites W1980848382 @default.
- W2767358767 cites W1980900061 @default.
- W2767358767 cites W1989938012 @default.
- W2767358767 cites W1995338323 @default.
- W2767358767 cites W1995878706 @default.
- W2767358767 cites W2003223749 @default.
- W2767358767 cites W2003262261 @default.
- W2767358767 cites W2006515382 @default.
- W2767358767 cites W2024765904 @default.
- W2767358767 cites W2031326555 @default.
- W2767358767 cites W2044407816 @default.
- W2767358767 cites W2050475853 @default.
- W2767358767 cites W2053927466 @default.
- W2767358767 cites W2056109978 @default.
- W2767358767 cites W2059106430 @default.
- W2767358767 cites W2062997257 @default.
- W2767358767 cites W2068120938 @default.
- W2767358767 cites W2071297085 @default.
- W2767358767 cites W2073641804 @default.
- W2767358767 cites W2081258564 @default.
- W2767358767 cites W2082040849 @default.
- W2767358767 cites W2091334314 @default.
- W2767358767 cites W2097942434 @default.
- W2767358767 cites W2101713299 @default.
- W2767358767 cites W2104135721 @default.
- W2767358767 cites W2106410563 @default.
- W2767358767 cites W2111900780 @default.
- W2767358767 cites W2114339366 @default.
- W2767358767 cites W2119979409 @default.
- W2767358767 cites W2124322010 @default.
- W2767358767 cites W2125595758 @default.
- W2767358767 cites W2131658531 @default.
- W2767358767 cites W2134742663 @default.
- W2767358767 cites W2134749898 @default.
- W2767358767 cites W2138093501 @default.
- W2767358767 cites W2150393481 @default.
- W2767358767 cites W2169304299 @default.
- W2767358767 cites W2172202847 @default.
- W2767358767 cites W2403659052 @default.
- W2767358767 cites W2415683910 @default.
- W2767358767 cites W2492225086 @default.
- W2767358767 cites W4232786548 @default.
- W2767358767 cites W4236300290 @default.
- W2767358767 cites W4237534021 @default.
- W2767358767 doi "https://doi.org/10.1038/s41467-017-01514-3" @default.
- W2767358767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5684212" @default.
- W2767358767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29133867" @default.
- W2767358767 hasPublicationYear "2017" @default.
- W2767358767 type Work @default.
- W2767358767 sameAs 2767358767 @default.
- W2767358767 citedByCount "17" @default.
- W2767358767 countsByYear W27673587672018 @default.
- W2767358767 countsByYear W27673587672019 @default.
- W2767358767 countsByYear W27673587672020 @default.
- W2767358767 countsByYear W27673587672021 @default.
- W2767358767 countsByYear W27673587672022 @default.
- W2767358767 countsByYear W27673587672023 @default.
- W2767358767 crossrefType "journal-article" @default.
- W2767358767 hasAuthorship W2767358767A5006745683 @default.
- W2767358767 hasAuthorship W2767358767A5010556487 @default.
- W2767358767 hasAuthorship W2767358767A5023387465 @default.
- W2767358767 hasAuthorship W2767358767A5029760404 @default.
- W2767358767 hasAuthorship W2767358767A5034002118 @default.
- W2767358767 hasAuthorship W2767358767A5045696330 @default.
- W2767358767 hasAuthorship W2767358767A5046675362 @default.
- W2767358767 hasAuthorship W2767358767A5048139572 @default.
- W2767358767 hasAuthorship W2767358767A5068920019 @default.
- W2767358767 hasBestOaLocation W27673587671 @default.
- W2767358767 hasConcept C104317684 @default.
- W2767358767 hasConcept C134018914 @default.
- W2767358767 hasConcept C138798377 @default.
- W2767358767 hasConcept C142724271 @default.
- W2767358767 hasConcept C148738053 @default.
- W2767358767 hasConcept C198826908 @default.
- W2767358767 hasConcept C201750760 @default.
- W2767358767 hasConcept C2779052135 @default.
- W2767358767 hasConcept C2779422105 @default.
- W2767358767 hasConcept C2780091579 @default.
- W2767358767 hasConcept C28328180 @default.
- W2767358767 hasConcept C31695470 @default.
- W2767358767 hasConcept C502942594 @default.
- W2767358767 hasConcept C54355233 @default.