Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767360024> ?p ?o ?g. }
- W2767360024 endingPage "240" @default.
- W2767360024 startingPage "219" @default.
- W2767360024 abstract "In recent years, breakthroughs in human pluripotent stem cell (hPSC) research, namely cellular reprogramming and the emergence of sophisticated genetic engineering technologies, have opened new frontiers for cell and gene therapy. The prospect of using hPSCs, either autologous or histocompatible, as targets of genetic modification and their differentiated progeny as cell products for transplantation, presents a new paradigm of regenerative medicine of potential tremendous value for the treatment of blood disorders, including beta-thalassemia (BT) and sickle cell disease (SCD). Despite advances at a remarkable pace and great promise, many roadblocks remain before clinical translation can be realistically considered. Here we discuss the theoretical advantages of cell therapies utilizing hPSC derivatives, recent proof-of-principle studies and the main challenges towards realizing the potential of hPSC therapies in the clinic." @default.
- W2767360024 created "2017-11-17" @default.
- W2767360024 creator A5061840849 @default.
- W2767360024 date "2017-01-01" @default.
- W2767360024 modified "2023-09-26" @default.
- W2767360024 title "Gene and Cell Therapy for β-Thalassemia and Sickle Cell Disease with Induced Pluripotent Stem Cells (iPSCs): The Next Frontier" @default.
- W2767360024 cites W1964294710 @default.
- W2767360024 cites W1966008305 @default.
- W2767360024 cites W1966095294 @default.
- W2767360024 cites W1968354447 @default.
- W2767360024 cites W1971496676 @default.
- W2767360024 cites W1974012915 @default.
- W2767360024 cites W1977889349 @default.
- W2767360024 cites W1980933256 @default.
- W2767360024 cites W1982360832 @default.
- W2767360024 cites W1984993302 @default.
- W2767360024 cites W1985964771 @default.
- W2767360024 cites W1986595047 @default.
- W2767360024 cites W1986744301 @default.
- W2767360024 cites W1986940374 @default.
- W2767360024 cites W1987111575 @default.
- W2767360024 cites W1987523847 @default.
- W2767360024 cites W1991037959 @default.
- W2767360024 cites W1992525863 @default.
- W2767360024 cites W1993834457 @default.
- W2767360024 cites W1997170085 @default.
- W2767360024 cites W2002402026 @default.
- W2767360024 cites W2002456771 @default.
- W2767360024 cites W2003171404 @default.
- W2767360024 cites W2004360848 @default.
- W2767360024 cites W2005163476 @default.
- W2767360024 cites W2005911189 @default.
- W2767360024 cites W2006283659 @default.
- W2767360024 cites W2006562250 @default.
- W2767360024 cites W2010031978 @default.
- W2767360024 cites W2011077415 @default.
- W2767360024 cites W2021581968 @default.
- W2767360024 cites W2022534144 @default.
- W2767360024 cites W2024533323 @default.
- W2767360024 cites W2028369290 @default.
- W2767360024 cites W2032002636 @default.
- W2767360024 cites W2032058920 @default.
- W2767360024 cites W2032424612 @default.
- W2767360024 cites W2034862301 @default.
- W2767360024 cites W2035792120 @default.
- W2767360024 cites W2036632122 @default.
- W2767360024 cites W2037149016 @default.
- W2767360024 cites W2037255620 @default.
- W2767360024 cites W2037322891 @default.
- W2767360024 cites W2037338370 @default.
- W2767360024 cites W2039648189 @default.
- W2767360024 cites W2045626197 @default.
- W2767360024 cites W2045859114 @default.
- W2767360024 cites W2047036934 @default.
- W2767360024 cites W2047658414 @default.
- W2767360024 cites W2049358079 @default.
- W2767360024 cites W2050160133 @default.
- W2767360024 cites W2050689355 @default.
- W2767360024 cites W2051272245 @default.
- W2767360024 cites W2052159842 @default.
- W2767360024 cites W2053911973 @default.
- W2767360024 cites W2057177784 @default.
- W2767360024 cites W2057856249 @default.
- W2767360024 cites W2059378220 @default.
- W2767360024 cites W2060255800 @default.
- W2767360024 cites W2061824613 @default.
- W2767360024 cites W2064820560 @default.
- W2767360024 cites W2068403109 @default.
- W2767360024 cites W2070357537 @default.
- W2767360024 cites W2070436275 @default.
- W2767360024 cites W2070672434 @default.
- W2767360024 cites W2071197860 @default.
- W2767360024 cites W2072239613 @default.
- W2767360024 cites W2076047032 @default.
- W2767360024 cites W2077806591 @default.
- W2767360024 cites W2081391072 @default.
- W2767360024 cites W2081620485 @default.
- W2767360024 cites W2086663462 @default.
- W2767360024 cites W2086943348 @default.
- W2767360024 cites W2088152986 @default.
- W2767360024 cites W2089486322 @default.
- W2767360024 cites W2092578550 @default.
- W2767360024 cites W2095041841 @default.
- W2767360024 cites W2096216062 @default.
- W2767360024 cites W2098170273 @default.
- W2767360024 cites W2098597036 @default.
- W2767360024 cites W2101569447 @default.
- W2767360024 cites W2102718460 @default.
- W2767360024 cites W2102875348 @default.
- W2767360024 cites W2103540918 @default.
- W2767360024 cites W2104978512 @default.
- W2767360024 cites W2106485710 @default.
- W2767360024 cites W2111920812 @default.
- W2767360024 cites W2114195485 @default.
- W2767360024 cites W2114648293 @default.
- W2767360024 cites W2115933858 @default.
- W2767360024 cites W2119458768 @default.
- W2767360024 cites W2125987139 @default.