FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767375851> ?p ?o ?g. }

• W2767375851 endingPage "2138" @default.
• W2767375851 startingPage "2128" @default.
• W2767375851 abstract "To untangle the complex signaling of the c-Jun N-terminal kinase (JNK) isoforms, we need tools that can selectively detect and inhibit individual isoforms. Because of the high similarity between JNK1, JNK2 and JNK3, it is very difficult to generate small-molecule inhibitors with this discriminatory power. Thus, we have recently selected protein binders from the designed ankyrin repeat protein (DARPin) library which were indeed isoform-specific inhibitors of JNK1 with low nanomolar potency. Here we provide the structural basis for their isotype discrimination and their inhibitory action. All our previous attempts to generate crystal structures of complexes had failed. We have now made use of a technology we recently developed which consists of rigid fusion of an additional special DARPin, which acts as a crystallization enhancer. This can be rigidly fused with different geometries, thereby generating a range of alternative crystal packings. The structures reveal the molecular basis for isoform specificity of the DARPins and their ability to prevent JNK activation and may thus form the basis of further investigation of the JNK family as well as novel approaches to drug design." @default.
• W2767375851 created "2017-11-17" @default.
• W2767375851 creator A5009946736 @default.
• W2767375851 creator A5025006805 @default.
• W2767375851 creator A5029337710 @default.
• W2767375851 creator A5029902815 @default.
• W2767375851 creator A5083658123 @default.
• W2767375851 date "2018-07-01" @default.
• W2767375851 modified "2023-10-03" @default.
• W2767375851 title "Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin–DARPin Fusions" @default.
• W2767375851 cites W112316751 @default.
• W2767375851 cites W1572174728 @default.
• W2767375851 cites W1922422478 @default.
• W2767375851 cites W1964267616 @default.
• W2767375851 cites W1977472414 @default.
• W2767375851 cites W1990418954 @default.
• W2767375851 cites W1994637653 @default.
• W2767375851 cites W1994793168 @default.
• W2767375851 cites W2009776832 @default.
• W2767375851 cites W2011760895 @default.
• W2767375851 cites W2016008760 @default.
• W2767375851 cites W2023568503 @default.
• W2767375851 cites W2039201738 @default.
• W2767375851 cites W2042277661 @default.
• W2767375851 cites W2052399945 @default.
• W2767375851 cites W2060795488 @default.
• W2767375851 cites W2062289724 @default.
• W2767375851 cites W2076485183 @default.
• W2767375851 cites W2077880395 @default.
• W2767375851 cites W2083911670 @default.
• W2767375851 cites W2084472730 @default.
• W2767375851 cites W2084938664 @default.
• W2767375851 cites W2088328768 @default.
• W2767375851 cites W2092803887 @default.
• W2767375851 cites W2093675973 @default.
• W2767375851 cites W2103197465 @default.
• W2767375851 cites W2104743811 @default.
• W2767375851 cites W2105888864 @default.
• W2767375851 cites W2112391609 @default.
• W2767375851 cites W2112731554 @default.
• W2767375851 cites W2114627684 @default.
• W2767375851 cites W2122052370 @default.
• W2767375851 cites W2122057254 @default.
• W2767375851 cites W2128781685 @default.
• W2767375851 cites W2132108032 @default.
• W2767375851 cites W2142478072 @default.
• W2767375851 cites W2144082239 @default.
• W2767375851 cites W2152091016 @default.
• W2767375851 cites W2153091201 @default.
• W2767375851 cites W2155510074 @default.
• W2767375851 cites W2158436034 @default.
• W2767375851 cites W2158885329 @default.
• W2767375851 cites W2165238581 @default.
• W2767375851 cites W2272628005 @default.
• W2767375851 cites W2294487613 @default.
• W2767375851 cites W2303511142 @default.
• W2767375851 cites W2317325743 @default.
• W2767375851 cites W2497333816 @default.
• W2767375851 cites W2528851536 @default.
• W2767375851 cites W2752629199 @default.
• W2767375851 cites W4248872320 @default.
• W2767375851 cites W4295216797 @default.
• W2767375851 doi "https://doi.org/10.1016/j.jmb.2017.10.032" @default.
• W2767375851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29126898" @default.
• W2767375851 hasPublicationYear "2018" @default.
• W2767375851 type Work @default.
• W2767375851 sameAs 2767375851 @default.
• W2767375851 citedByCount "12" @default.
• W2767375851 countsByYear W27673758512019 @default.
• W2767375851 countsByYear W27673758512020 @default.
• W2767375851 countsByYear W27673758512021 @default.
• W2767375851 countsByYear W27673758512022 @default.
• W2767375851 countsByYear W27673758512023 @default.
• W2767375851 crossrefType "journal-article" @default.
• W2767375851 hasAuthorship W2767375851A5009946736 @default.
• W2767375851 hasAuthorship W2767375851A5025006805 @default.
• W2767375851 hasAuthorship W2767375851A5029337710 @default.
• W2767375851 hasAuthorship W2767375851A5029902815 @default.
• W2767375851 hasAuthorship W2767375851A5083658123 @default.
• W2767375851 hasConcept C104317684 @default.
• W2767375851 hasConcept C111936080 @default.
• W2767375851 hasConcept C113241181 @default.
• W2767375851 hasConcept C123894998 @default.
• W2767375851 hasConcept C161624437 @default.
• W2767375851 hasConcept C184235292 @default.
• W2767375851 hasConcept C40767141 @default.
• W2767375851 hasConcept C53345823 @default.
• W2767375851 hasConcept C55493867 @default.
• W2767375851 hasConcept C70721500 @default.
• W2767375851 hasConcept C86339819 @default.
• W2767375851 hasConcept C86803240 @default.
• W2767375851 hasConcept C95444343 @default.
• W2767375851 hasConceptScore W2767375851C104317684 @default.
• W2767375851 hasConceptScore W2767375851C111936080 @default.
• W2767375851 hasConceptScore W2767375851C113241181 @default.
• W2767375851 hasConceptScore W2767375851C123894998 @default.
• W2767375851 hasConceptScore W2767375851C161624437 @default.
• W2767375851 hasConceptScore W2767375851C184235292 @default.

• next