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- W2767379772 abstract "Mitral valve prolapse (MVP) is a common heritable valvulopathy affecting approximately 2.4% of the population. It is the most important cause of primary mitral regurgitation (MR) requiring surgery. MVP is characterized by fibromyxomatous changes and displacement of one or both mitral leaflets into the left atrium. Echocardiography represents the primary diagnostic modality for assessment of MVP. Accurate quantitation of ventricular volumes and function for surgical planning in asymptomatic severe MR can be provided with both echocardiography and cardiac magnetic resonance. In addition, assessment of myocardial fibrosis using late gadolinium enhancement and T1 mapping allows better understanding of the impact of MVP on the myocardium. Imaging in MVP is important not only for diagnostic and prognostic purposes, but is also essential for detailed phenotyping in genetic studies. Genotype-phenotype studies in MVP pedigrees have allowed the identification of milder, non-diagnostic MVP morphologies by echocardiography. Such morphologies represent early expression of MVP in gene carriers. This review focuses on multimodality imaging and the phenotypic spectrum of MVP. Moreover, the review details the recent genetic discoveries that have increased our understanding of the pathophysiology of MVP, with clues to mechanisms and therapy." @default.
- W2767379772 created "2017-11-17" @default.
- W2767379772 creator A5003717488 @default.
- W2767379772 creator A5066449262 @default.
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- W2767379772 creator A5083746681 @default.
- W2767379772 date "2017-11-01" @default.
- W2767379772 modified "2023-10-01" @default.
- W2767379772 title "Mitral Valve Prolapse: Multimodality Imaging and Genetic Insights" @default.
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- W2767379772 doi "https://doi.org/10.1016/j.pcad.2017.10.007" @default.
- W2767379772 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5805573" @default.
- W2767379772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29122631" @default.
- W2767379772 hasPublicationYear "2017" @default.
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