FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767387764> ?p ?o ?g. }

• W2767387764 endingPage "9" @default.
• W2767387764 startingPage "1" @default.
• W2767387764 abstract "Purpose To determine a reliable method of using the ellipsoid zone (EZ) on optical coherence tomography (OCT) to track disease progression in Stardgardt disease (STGD). Design Retrospective reliability study. Methods STGD patients with genetically confirmed ABCA4 gene mutations seen at the Wilmer Eye Institute with follow-up visits separated by at least 12 months were identified. Spectral-domain optical coherence tomography (SD-OCT) macula volume scans centered at the fovea and fundus autofluorescence (FAF) images were obtained. The area of EZ loss was calculated from the SD-OCT and the area of retinal pigment epithelium (RPE) loss from the FAF. Scans were reanalyzed by the primary grader to assess intragrader reliability, and reanalyzed by a second grader to assess intergrader reliability. Results Sixteen STGD patients (total of 31 eyes) were followed for a mean of 2 years (range 1–4.7 years). The mean rate of EZ loss, 0.31 ± 0.31 mm2/year, was similar to the average rate of RPE loss, 0.33 ± 0.38 mm2/year. The average area of EZ loss at the initial examination, 4.18 ± 1.91 mm2, was larger than the initial area of RPE loss, 2.25 ± 1.66 mm2 (P < .01). The absolute difference of the area of EZ loss on test-retest for the first grader was 0.12 ± 0.10 mm2, and between graders 0.21 ± 0.21 mm2. The intraclass correlation (ICC) of both intragrader and intergrader reliability for EZ loss was excellent at 0.99. Conclusions Tracking the area of EZ loss on SD-OCT macular volume scans longitudinally is a reliable way of monitoring disease progression in STGD. This could be used as a sensitive anatomic outcome measure in clinical trials related to STGD. To determine a reliable method of using the ellipsoid zone (EZ) on optical coherence tomography (OCT) to track disease progression in Stardgardt disease (STGD). Retrospective reliability study. STGD patients with genetically confirmed ABCA4 gene mutations seen at the Wilmer Eye Institute with follow-up visits separated by at least 12 months were identified. Spectral-domain optical coherence tomography (SD-OCT) macula volume scans centered at the fovea and fundus autofluorescence (FAF) images were obtained. The area of EZ loss was calculated from the SD-OCT and the area of retinal pigment epithelium (RPE) loss from the FAF. Scans were reanalyzed by the primary grader to assess intragrader reliability, and reanalyzed by a second grader to assess intergrader reliability. Sixteen STGD patients (total of 31 eyes) were followed for a mean of 2 years (range 1–4.7 years). The mean rate of EZ loss, 0.31 ± 0.31 mm2/year, was similar to the average rate of RPE loss, 0.33 ± 0.38 mm2/year. The average area of EZ loss at the initial examination, 4.18 ± 1.91 mm2, was larger than the initial area of RPE loss, 2.25 ± 1.66 mm2 (P < .01). The absolute difference of the area of EZ loss on test-retest for the first grader was 0.12 ± 0.10 mm2, and between graders 0.21 ± 0.21 mm2. The intraclass correlation (ICC) of both intragrader and intergrader reliability for EZ loss was excellent at 0.99. Tracking the area of EZ loss on SD-OCT macular volume scans longitudinally is a reliable way of monitoring disease progression in STGD. This could be used as a sensitive anatomic outcome measure in clinical trials related to STGD." @default.
• W2767387764 created "2017-11-17" @default.
• W2767387764 creator A5058002567 @default.
• W2767387764 creator A5066829896 @default.
• W2767387764 creator A5067830794 @default.
• W2767387764 date "2018-02-01" @default.
• W2767387764 modified "2023-09-23" @default.
• W2767387764 title "Quantifying the Rate of Ellipsoid Zone Loss in Stargardt Disease" @default.
• W2767387764 cites W1099014679 @default.
• W2767387764 cites W1508103243 @default.
• W2767387764 cites W162823058 @default.
• W2767387764 cites W1966039514 @default.
• W2767387764 cites W1966672715 @default.
• W2767387764 cites W1971270699 @default.
• W2767387764 cites W1974006653 @default.
• W2767387764 cites W1975348685 @default.
• W2767387764 cites W1976041506 @default.
• W2767387764 cites W1985659341 @default.
• W2767387764 cites W1985683301 @default.
• W2767387764 cites W1990068376 @default.
• W2767387764 cites W1990208195 @default.
• W2767387764 cites W1994172606 @default.
• W2767387764 cites W2001827423 @default.
• W2767387764 cites W2005272715 @default.
• W2767387764 cites W2005970825 @default.
• W2767387764 cites W2009159665 @default.
• W2767387764 cites W2031287535 @default.
• W2767387764 cites W2068607898 @default.
• W2767387764 cites W2071088429 @default.
• W2767387764 cites W2074035096 @default.
• W2767387764 cites W2074854567 @default.
• W2767387764 cites W2076335096 @default.
• W2767387764 cites W2087406399 @default.
• W2767387764 cites W2094844827 @default.
• W2767387764 cites W2097343059 @default.
• W2767387764 cites W2109159638 @default.
• W2767387764 cites W2117340238 @default.
• W2767387764 cites W2121918635 @default.
• W2767387764 cites W2123330867 @default.
• W2767387764 cites W2124381750 @default.
• W2767387764 cites W2124851578 @default.
• W2767387764 cites W2134897973 @default.
• W2767387764 cites W2141716243 @default.
• W2767387764 cites W2142904179 @default.
• W2767387764 cites W2154399840 @default.
• W2767387764 cites W2168030414 @default.
• W2767387764 cites W2220452512 @default.
• W2767387764 cites W2225425408 @default.
• W2767387764 cites W2277641745 @default.
• W2767387764 cites W2286553380 @default.
• W2767387764 cites W2320670580 @default.
• W2767387764 cites W2332643163 @default.
• W2767387764 cites W2405824385 @default.
• W2767387764 cites W2417738566 @default.
• W2767387764 cites W2462754021 @default.
• W2767387764 cites W2473036438 @default.
• W2767387764 cites W2527764618 @default.
• W2767387764 cites W2574176037 @default.
• W2767387764 cites W2600576274 @default.
• W2767387764 cites W2612647476 @default.
• W2767387764 cites W2619207136 @default.
• W2767387764 cites W2623547899 @default.
• W2767387764 cites W2626203798 @default.
• W2767387764 cites W73797966 @default.
• W2767387764 cites W906393181 @default.
• W2767387764 doi "https://doi.org/10.1016/j.ajo.2017.10.032" @default.
• W2767387764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29126757" @default.
• W2767387764 hasPublicationYear "2018" @default.
• W2767387764 type Work @default.
• W2767387764 sameAs 2767387764 @default.
• W2767387764 citedByCount "30" @default.
• W2767387764 countsByYear W27673877642018 @default.
• W2767387764 countsByYear W27673877642019 @default.
• W2767387764 countsByYear W27673877642020 @default.
• W2767387764 countsByYear W27673877642021 @default.
• W2767387764 countsByYear W27673877642022 @default.
• W2767387764 countsByYear W27673877642023 @default.
• W2767387764 crossrefType "journal-article" @default.
• W2767387764 hasAuthorship W2767387764A5058002567 @default.
• W2767387764 hasAuthorship W2767387764A5066829896 @default.
• W2767387764 hasAuthorship W2767387764A5067830794 @default.
• W2767387764 hasConcept C104317684 @default.
• W2767387764 hasConcept C104709138 @default.
• W2767387764 hasConcept C118487528 @default.
• W2767387764 hasConcept C127716648 @default.
• W2767387764 hasConcept C171606756 @default.
• W2767387764 hasConcept C2776391266 @default.
• W2767387764 hasConcept C2778024200 @default.
• W2767387764 hasConcept C2778818243 @default.
• W2767387764 hasConcept C2779460726 @default.
• W2767387764 hasConcept C2780604041 @default.
• W2767387764 hasConcept C2780827179 @default.
• W2767387764 hasConcept C2989005 @default.
• W2767387764 hasConcept C54355233 @default.
• W2767387764 hasConcept C70410870 @default.
• W2767387764 hasConcept C71924100 @default.
• W2767387764 hasConcept C86803240 @default.
• W2767387764 hasConceptScore W2767387764C104317684 @default.

• next