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- W2767394086 abstract "Rosmarinic acid (RA), a bioactive compound isolated from Rosmarinus officinalis exhibits multiple pharmacological activities, including antioxidant, anti-allergic and anti-inflammatory effects. Herein, we report the synthesis of new series of amide analogs of rosmarinic acid along with their antioxidant potential. Highest DPPH scavenging effect was observed in case of (E)-3-(3,4-dihydroxy-phenyl)-1-((4-fluorophenyl)amino)-1-oxopropan-2-yl-3-(3,4dihydroxy phenyl)acrylate (RA-15) displaying an IC50 of 3.19 μg/ml compared to standard ascorbic acid (IC50=4.09 μg/ml). However (E)-3-(3,4-dihydroxyphenyl)-1-((4-hydroxyphenyl)amino)-1-oxopropan-2-yl-3-(3, 4-dihydroxyphenyl)acrylate (RA-10) displayed the highest hydroxy radical scavenging effect exhibiting an IC50 of 8.98 μg/ml compared to standard ascorbic acid (IC50=9.00 μg/ml). This study thus, provides an important aspect with regard to the use of these rosmarinic acid-based antioxidants in food industry as dietary supplements." @default.
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- W2767394086 date "2017-10-31" @default.
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- W2767394086 title "New Semi-Synthetic Rosmarinic Acid-Based Amide Derivatives as Effective Antioxidants" @default.
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- W2767394086 doi "https://doi.org/10.1002/slct.201701812" @default.
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