Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767421084> ?p ?o ?g. }
- W2767421084 endingPage "1300" @default.
- W2767421084 startingPage "1289" @default.
- W2767421084 abstract "ABSTRACT Inflammation of the middle ear, known clinically as chronic otitis media, presents in different forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative otitis media (CSOM). These are highly prevalent diseases, especially in childhood, and lead to significant morbidity worldwide. However, much remains unclear about this disease, including its aetiology, initiation and perpetuation, and the relative roles of mucosal and leukocyte biology, pathogens, and Eustachian tube function. Chronic otitis media is commonly modelled in mice but most existing models only partially mimic human disease and many are syndromic. Nevertheless, these models have provided insights into potential disease mechanisms, and have implicated altered immune signalling, mucociliary function and Eustachian tube function as potential predisposing mechanisms. Clinical studies of chronic otitis media have yet to implicate a particular molecular pathway or mechanism, and current human genetic studies are underpowered. We also do not fully understand how existing interventions, such as tympanic membrane repair, work, nor how chronic otitis media spontaneously resolves. This Clinical Puzzle article describes our current knowledge of chronic otitis media and the existing research models for this condition. It also identifies unanswered questions about its pathogenesis and treatment, with the goal of advancing our understanding of this disease to aid the development of novel therapeutic interventions." @default.
- W2767421084 created "2017-11-17" @default.
- W2767421084 creator A5002413517 @default.
- W2767421084 creator A5028203458 @default.
- W2767421084 creator A5029100831 @default.
- W2767421084 creator A5077835291 @default.
- W2767421084 creator A5079221956 @default.
- W2767421084 date "2017-11-01" @default.
- W2767421084 modified "2023-10-16" @default.
- W2767421084 title "Understanding the aetiology and resolution of chronic otitis media from animal and human studies" @default.
- W2767421084 cites W1490016222 @default.
- W2767421084 cites W1490329668 @default.
- W2767421084 cites W1530683631 @default.
- W2767421084 cites W1554676536 @default.
- W2767421084 cites W1563674700 @default.
- W2767421084 cites W1629027561 @default.
- W2767421084 cites W1680323362 @default.
- W2767421084 cites W1821570855 @default.
- W2767421084 cites W1849565921 @default.
- W2767421084 cites W1863597969 @default.
- W2767421084 cites W1866897735 @default.
- W2767421084 cites W1932972313 @default.
- W2767421084 cites W1964876766 @default.
- W2767421084 cites W1968343946 @default.
- W2767421084 cites W1972134603 @default.
- W2767421084 cites W1972950453 @default.
- W2767421084 cites W1978556994 @default.
- W2767421084 cites W1978850725 @default.
- W2767421084 cites W1978978834 @default.
- W2767421084 cites W1982385503 @default.
- W2767421084 cites W1985551370 @default.
- W2767421084 cites W1986428805 @default.
- W2767421084 cites W1989338929 @default.
- W2767421084 cites W1990896073 @default.
- W2767421084 cites W1998925544 @default.
- W2767421084 cites W1999395327 @default.
- W2767421084 cites W2000568400 @default.
- W2767421084 cites W2003637263 @default.
- W2767421084 cites W2005270567 @default.
- W2767421084 cites W2006435897 @default.
- W2767421084 cites W2009082801 @default.
- W2767421084 cites W2010314221 @default.
- W2767421084 cites W2010746507 @default.
- W2767421084 cites W2011436409 @default.
- W2767421084 cites W2013011285 @default.
- W2767421084 cites W2017927320 @default.
- W2767421084 cites W2021784539 @default.
- W2767421084 cites W2022966386 @default.
- W2767421084 cites W2023642765 @default.
- W2767421084 cites W2024823140 @default.
- W2767421084 cites W2025846113 @default.
- W2767421084 cites W2028155382 @default.
- W2767421084 cites W2028595351 @default.
- W2767421084 cites W2030046796 @default.
- W2767421084 cites W2031303426 @default.
- W2767421084 cites W2031498219 @default.
- W2767421084 cites W2033799388 @default.
- W2767421084 cites W2034986174 @default.
- W2767421084 cites W2035361700 @default.
- W2767421084 cites W2037332112 @default.
- W2767421084 cites W2043623581 @default.
- W2767421084 cites W2046374018 @default.
- W2767421084 cites W2048301503 @default.
- W2767421084 cites W2048460968 @default.
- W2767421084 cites W2049106620 @default.
- W2767421084 cites W2049435467 @default.
- W2767421084 cites W2050812658 @default.
- W2767421084 cites W2054278762 @default.
- W2767421084 cites W2058435624 @default.
- W2767421084 cites W2059481638 @default.
- W2767421084 cites W2062526825 @default.
- W2767421084 cites W2062726834 @default.
- W2767421084 cites W2062852135 @default.
- W2767421084 cites W2067516057 @default.
- W2767421084 cites W2067545309 @default.
- W2767421084 cites W2070881691 @default.
- W2767421084 cites W2071002080 @default.
- W2767421084 cites W2079911608 @default.
- W2767421084 cites W2080344832 @default.
- W2767421084 cites W2082766566 @default.
- W2767421084 cites W2084325501 @default.
- W2767421084 cites W2085083623 @default.
- W2767421084 cites W2085557540 @default.
- W2767421084 cites W2086346253 @default.
- W2767421084 cites W2089667253 @default.
- W2767421084 cites W2090738844 @default.
- W2767421084 cites W2095074862 @default.
- W2767421084 cites W2098630506 @default.
- W2767421084 cites W2100998632 @default.
- W2767421084 cites W2102678152 @default.
- W2767421084 cites W2110894673 @default.
- W2767421084 cites W2112243650 @default.
- W2767421084 cites W2114639942 @default.
- W2767421084 cites W2118949960 @default.
- W2767421084 cites W2121294464 @default.
- W2767421084 cites W2122713667 @default.
- W2767421084 cites W2122723511 @default.
- W2767421084 cites W2123939370 @default.