FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767447716> ?p ?o ?g. }

• W2767447716 abstract "Abstract Considerable evidence has shown that prefrontal neurons expressing D1-type dopamine receptors (D1DRs) are critical for working memory, flexibility, and timing. This line of work predicts that frontal neurons expressing D1DRs mediate cognitive processing. During timing tasks, one form this cognitive processing might take is time-dependent ramping activity — monotonic changes in firing rate over time. Thus, we hypothesized the prefrontal D1DR+ neurons would strongly exhibited time-dependent ramping during interval timing. We tested this idea using an interval-timing task in which we used optogenetics to tag D1DR+ neurons in the mouse medial frontal cortex (MFC). While 23% of MFC D1DR+ neurons exhibited ramping, this was significantly less than untagged MFC D1DR+ neurons. By contrast, MFC D1DR+ neurons had strong delta-frequency (1-4 Hz) coherence with other MFC ramping neurons. This coherence was phase-locked to cue onset and was strongest early in the interval. To test the significance of these interactions, we optogenetically stimulated MFC D1DR+ neurons early vs. late in the interval. We found that 2-Hz stimulation early in the interval was particularly effective in rescuing timing-related behavioral performance deficits in dopamine-depleted animals. These findings provide insight into MFC networks and have relevance for disorders such as Parkinson’s disease and schizophrenia. Significance Statement Prefrontal D1DRs are involved in cognitive processing and cognitive dysfunction in human diseases such as Parkinson’s disease and schizophrenia. We use optogenetics to identify these neurons, as well as neurons that are putatively connected to MFC D1DR+ neurons. We study these neurons in detail during an elementary cognitive task. These data could have relevance for cognitive deficits for Parkinson’s disease, schizophrenia, and other diseases involving frontal dopamine." @default.
• W2767447716 created "2017-11-17" @default.
• W2767447716 creator A5056004053 @default.
• W2767447716 creator A5082128655 @default.
• W2767447716 date "2017-11-10" @default.
• W2767447716 modified "2023-09-26" @default.
• W2767447716 title "Prefrontal D1 dopamine-receptor neurons and delta resonance in interval timing" @default.
• W2767447716 cites W1529892095 @default.
• W2767447716 cites W1535834148 @default.
• W2767447716 cites W1819927624 @default.
• W2767447716 cites W1977138162 @default.
• W2767447716 cites W1979942203 @default.
• W2767447716 cites W1980727604 @default.
• W2767447716 cites W1994858223 @default.
• W2767447716 cites W2000621650 @default.
• W2767447716 cites W2005427299 @default.
• W2767447716 cites W2011683094 @default.
• W2767447716 cites W2012493789 @default.
• W2767447716 cites W2023215474 @default.
• W2767447716 cites W2024403313 @default.
• W2767447716 cites W2029782870 @default.
• W2767447716 cites W2031397909 @default.
• W2767447716 cites W2034525645 @default.
• W2767447716 cites W2037799143 @default.
• W2767447716 cites W2037843057 @default.
• W2767447716 cites W2046835548 @default.
• W2767447716 cites W2058396154 @default.
• W2767447716 cites W2073727525 @default.
• W2767447716 cites W2077767624 @default.
• W2767447716 cites W2080154019 @default.
• W2767447716 cites W2082310730 @default.
• W2767447716 cites W2083972263 @default.
• W2767447716 cites W2084007108 @default.
• W2767447716 cites W2094134651 @default.
• W2767447716 cites W2101948750 @default.
• W2767447716 cites W2102132106 @default.
• W2767447716 cites W2109056489 @default.
• W2767447716 cites W2113174266 @default.
• W2767447716 cites W2114984406 @default.
• W2767447716 cites W2128884218 @default.
• W2767447716 cites W2149561999 @default.
• W2767447716 cites W2156430527 @default.
• W2767447716 cites W2156580894 @default.
• W2767447716 cites W2163433107 @default.
• W2767447716 cites W2163919991 @default.
• W2767447716 cites W2164011442 @default.
• W2767447716 cites W2164146725 @default.
• W2767447716 cites W2171332611 @default.
• W2767447716 cites W2171521575 @default.
• W2767447716 cites W2254893974 @default.
• W2767447716 cites W2328983952 @default.
• W2767447716 cites W2466235064 @default.
• W2767447716 cites W2564240520 @default.
• W2767447716 cites W2587307788 @default.
• W2767447716 cites W2590185021 @default.
• W2767447716 cites W2598359378 @default.
• W2767447716 cites W2619500813 @default.
• W2767447716 cites W2733484636 @default.
• W2767447716 cites W2742906651 @default.
• W2767447716 cites W2746931880 @default.
• W2767447716 doi "https://doi.org/10.1101/216473" @default.
• W2767447716 hasPublicationYear "2017" @default.
• W2767447716 type Work @default.
• W2767447716 sameAs 2767447716 @default.
• W2767447716 citedByCount "4" @default.
• W2767447716 countsByYear W27674477162019 @default.
• W2767447716 countsByYear W27674477162020 @default.
• W2767447716 countsByYear W27674477162021 @default.
• W2767447716 countsByYear W27674477162022 @default.
• W2767447716 crossrefType "posted-content" @default.
• W2767447716 hasAuthorship W2767447716A5056004053 @default.
• W2767447716 hasAuthorship W2767447716A5082128655 @default.
• W2767447716 hasBestOaLocation W27674477161 @default.
• W2767447716 hasConcept C118552586 @default.
• W2767447716 hasConcept C15744967 @default.
• W2767447716 hasConcept C169760540 @default.
• W2767447716 hasConcept C169900460 @default.
• W2767447716 hasConcept C21963081 @default.
• W2767447716 hasConcept C2776412080 @default.
• W2767447716 hasConcept C2778794669 @default.
• W2767447716 hasConcept C2781195155 @default.
• W2767447716 hasConcept C50738837 @default.
• W2767447716 hasConcept C513476851 @default.
• W2767447716 hasConcept C66102695 @default.
• W2767447716 hasConceptScore W2767447716C118552586 @default.
• W2767447716 hasConceptScore W2767447716C15744967 @default.
• W2767447716 hasConceptScore W2767447716C169760540 @default.
• W2767447716 hasConceptScore W2767447716C169900460 @default.
• W2767447716 hasConceptScore W2767447716C21963081 @default.
• W2767447716 hasConceptScore W2767447716C2776412080 @default.
• W2767447716 hasConceptScore W2767447716C2778794669 @default.
• W2767447716 hasConceptScore W2767447716C2781195155 @default.
• W2767447716 hasConceptScore W2767447716C50738837 @default.
• W2767447716 hasConceptScore W2767447716C513476851 @default.
• W2767447716 hasConceptScore W2767447716C66102695 @default.
• W2767447716 hasLocation W27674477161 @default.
• W2767447716 hasLocation W27674477162 @default.
• W2767447716 hasOpenAccess W2767447716 @default.
• W2767447716 hasPrimaryLocation W27674477161 @default.
• W2767447716 hasRelatedWork W1984038015 @default.

• next