FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767469855> ?p ?o ?g. }

• W2767469855 endingPage "e1002420" @default.
• W2767469855 startingPage "e1002420" @default.
• W2767469855 abstract "Gaps in the HIV care continuum contribute to poor health outcomes and increase HIV transmission. A combination of interventions targeting multiple steps in the continuum is needed to achieve the full beneficial impact of HIV treatment.Link4Health, a cluster-randomized controlled trial, evaluated the effectiveness of a combination intervention strategy (CIS) versus the standard of care (SOC) on the primary outcome of linkage to care within 1 month plus retention in care at 12 months after HIV-positive testing. Ten clusters of HIV clinics in Swaziland were randomized 1:1 to CIS versus SOC. The CIS included point-of-care CD4+ testing at the time of an HIV-positive test, accelerated antiretroviral therapy (ART) initiation for treatment-eligible participants, mobile phone appointment reminders, health educational packages, and noncash financial incentives. Secondary outcomes included each component of the primary outcome, mean time to linkage, assessment for ART eligibility, ART initiation and time to ART initiation, viral suppression defined as HIV-1 RNA < 1,000 copies/mL at 12 months after HIV testing among patients on ART ≥6 months, and loss to follow-up and death at 12 months after HIV testing. A total of 2,197 adults aged ≥18 years, newly tested HIV positive, were enrolled from 19 August 2013 to 21 November 2014 (1,096 CIS arm; 1,101 SOC arm) and followed for 12 months. The median participant age was 31 years (IQR 26-39), and 59% were women. In an intention-to-treat analysis, 64% (705/1,096) of participants at the CIS sites achieved the primary outcome versus 43% (477/1,101) at the SOC sites (adjusted relative risk [RR] 1.52, 95% CI 1.19-1.96, p = 0.002). Participants in the CIS arm versus the SOC arm had the following secondary outcomes: linkage to care regardless of retention at 12 months (RR 1.08, 95% CI 0.97-1.21, p = 0.13), mean time to linkage (2.5 days versus 7.5 days, p = 0.189), retention in care at 12 months regardless of time to linkage (RR 1.48, 95% CI 1.18-1.86, p = 0.002), assessment for ART eligibility (RR 1.20, 95% CI 1.07-1.34, p = 0.004), ART initiation (RR 1.16, 95% CI 0.96-1.40, p = 0.12), mean time to ART initiation from time of HIV testing (7 days versus 14 days, p < 0.001), viral suppression among those on ART for ≥6 months (RR 0.97, 95% CI 0.88-1.07, p = 0.55), loss to follow-up at 12 months after HIV testing (RR 0.56, 95% CI 0.40-0.79, p = 0.002), and death (N = 78) within 12 months of HIV testing (RR 0.80, 95% CI 0.46-1.35, p = 0.41). Limitations of this study include a small number of clusters and the inability to evaluate the incremental effectiveness of individual components of the combination strategy.A combination strategy inclusive of 5 evidence-based interventions aimed at multiple steps in the HIV care continuum was associated with significant increase in linkage to care plus 12-month retention. This strategy offers promise of enhanced outcomes for HIV-positive patients.ClinicalTrials.gov NCT01904994." @default.
• W2767469855 created "2017-11-17" @default.
• W2767469855 creator A5008235594 @default.
• W2767469855 creator A5010009356 @default.
• W2767469855 creator A5012979486 @default.
• W2767469855 creator A5018518243 @default.
• W2767469855 creator A5030189215 @default.
• W2767469855 creator A5060621329 @default.
• W2767469855 creator A5061035170 @default.
• W2767469855 creator A5086932598 @default.
• W2767469855 creator A5088549098 @default.
• W2767469855 creator A5090406318 @default.
• W2767469855 date "2017-11-07" @default.
• W2767469855 modified "2023-10-14" @default.
• W2767469855 title "Effectiveness of a combination strategy for linkage and retention in adult HIV care in Swaziland: The Link4Health cluster randomized trial" @default.
• W2767469855 cites W1524256346 @default.
• W2767469855 cites W158671762 @default.
• W2767469855 cites W1838189248 @default.
• W2767469855 cites W193072286 @default.
• W2767469855 cites W1982680448 @default.
• W2767469855 cites W1995145495 @default.
• W2767469855 cites W1999945266 @default.
• W2767469855 cites W2005407737 @default.
• W2767469855 cites W2009586915 @default.
• W2767469855 cites W2021342127 @default.
• W2767469855 cites W2024135879 @default.
• W2767469855 cites W2039836366 @default.
• W2767469855 cites W2048986863 @default.
• W2767469855 cites W2055868383 @default.
• W2767469855 cites W2065962849 @default.
• W2767469855 cites W2073173905 @default.
• W2767469855 cites W2075548855 @default.
• W2767469855 cites W2093456972 @default.
• W2767469855 cites W2094200572 @default.
• W2767469855 cites W2107128582 @default.
• W2767469855 cites W2114990707 @default.
• W2767469855 cites W2115068541 @default.
• W2767469855 cites W2115313777 @default.
• W2767469855 cites W2126078440 @default.
• W2767469855 cites W2128901858 @default.
• W2767469855 cites W2135279501 @default.
• W2767469855 cites W2137576580 @default.
• W2767469855 cites W2148958761 @default.
• W2767469855 cites W2152505869 @default.
• W2767469855 cites W2153360349 @default.
• W2767469855 cites W2159612600 @default.
• W2767469855 cites W2170138433 @default.
• W2767469855 cites W2279894434 @default.
• W2767469855 cites W2291088382 @default.
• W2767469855 cites W2363480212 @default.
• W2767469855 cites W2393834324 @default.
• W2767469855 cites W2508191793 @default.
• W2767469855 cites W2509432012 @default.
• W2767469855 cites W2510792308 @default.
• W2767469855 cites W2512229472 @default.
• W2767469855 cites W2550098977 @default.
• W2767469855 cites W2626716901 @default.
• W2767469855 cites W2737303094 @default.
• W2767469855 cites W3122161101 @default.
• W2767469855 doi "https://doi.org/10.1371/journal.pmed.1002420" @default.
• W2767469855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5675376" @default.
• W2767469855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29112963" @default.
• W2767469855 hasPublicationYear "2017" @default.
• W2767469855 type Work @default.
• W2767469855 sameAs 2767469855 @default.
• W2767469855 citedByCount "58" @default.
• W2767469855 countsByYear W27674698552017 @default.
• W2767469855 countsByYear W27674698552018 @default.
• W2767469855 countsByYear W27674698552019 @default.
• W2767469855 countsByYear W27674698552020 @default.
• W2767469855 countsByYear W27674698552021 @default.
• W2767469855 countsByYear W27674698552022 @default.
• W2767469855 countsByYear W27674698552023 @default.
• W2767469855 crossrefType "journal-article" @default.
• W2767469855 hasAuthorship W2767469855A5008235594 @default.
• W2767469855 hasAuthorship W2767469855A5010009356 @default.
• W2767469855 hasAuthorship W2767469855A5012979486 @default.
• W2767469855 hasAuthorship W2767469855A5018518243 @default.
• W2767469855 hasAuthorship W2767469855A5030189215 @default.
• W2767469855 hasAuthorship W2767469855A5060621329 @default.
• W2767469855 hasAuthorship W2767469855A5061035170 @default.
• W2767469855 hasAuthorship W2767469855A5086932598 @default.
• W2767469855 hasAuthorship W2767469855A5088549098 @default.
• W2767469855 hasAuthorship W2767469855A5090406318 @default.
• W2767469855 hasBestOaLocation W27674698551 @default.
• W2767469855 hasConcept C126322002 @default.
• W2767469855 hasConcept C142462285 @default.
• W2767469855 hasConcept C159110408 @default.
• W2767469855 hasConcept C164866538 @default.
• W2767469855 hasConcept C168563851 @default.
• W2767469855 hasConcept C176400912 @default.
• W2767469855 hasConcept C187212893 @default.
• W2767469855 hasConcept C199360897 @default.
• W2767469855 hasConcept C27415008 @default.
• W2767469855 hasConcept C3013748606 @default.
• W2767469855 hasConcept C41008148 @default.
• W2767469855 hasConcept C512399662 @default.
• W2767469855 hasConcept C71924100 @default.

• next