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- W2767491025 abstract "Stroke represents the leading cause of long-term disability in adults worldwide. Most stroke survivors suffer from lifelong neurological deficits. Developing a pharmaceutical approach to enhance brain repair and improve functional outcomes post-acute stroke is a very important but less investigated area in stroke research. Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are the well-characterized vital hematopoietic growth factors for regulating hematopoiesis. Increasing evidence supports that SCF and G-CSF also play roles in the nervous system. Over the past decade, preclinical studies have demonstrated that SCF in combination with G-CSF synergistically enhances stroke recovery in the subacute or chronic phase. In this chapter, we have reviewed the biological function of SCF and G-CSF in hematopoiesis, neural plasticity, and neurogenesis, and summarized the preclinical studies illustrating the neurorestorative effects of SCF and G-CSF post-acute stroke." @default.
- W2767491025 created "2017-11-17" @default.
- W2767491025 creator A5019435679 @default.
- W2767491025 creator A5049275369 @default.
- W2767491025 creator A5069758035 @default.
- W2767491025 date "2017-11-07" @default.
- W2767491025 modified "2023-09-24" @default.
- W2767491025 title "The Combination of Stem Cell Factor (SCF) and Granulocyte-Colony Stimulating Factor (G-CSF) in Repairing the Brain Post-acute Stroke" @default.
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