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- W2767493982 endingPage "2440" @default.
- W2767493982 startingPage "2431" @default.
- W2767493982 abstract "The majority of older adults who develop heart failure (HF), particularly older women, have a preserved left ventricular ejection fraction (HFpEF). The prevalence of this syndrome is increasing, and the prognosis is not improving, unlike that of HF with reduced ejection fraction (HFrEF). Individuals with HFpEF have severe symptoms of effort intolerance, poor quality of life, frequent hospitalizations, and greater likelihood of death. Despite the importance of HFpEF, there are numerous major gaps in our understanding of its pathophysiology and management. Although it was originally viewed as a disorder due solely to abnormalities in left ventricular diastolic function, our understanding has evolved such that HFpEF is now understood as a systemic syndrome involving multiple organ systems, and it is likely that it is triggered by inflammation and other as-yet-unidentified circulating factors, with important contributions of aging and multiple comorbidities, features generally typical of other geriatric syndromes. We present an update on the pathophysiology, diagnosis, management, and future directions in this disorder in older persons." @default.
- W2767493982 created "2017-11-17" @default.
- W2767493982 creator A5015017115 @default.
- W2767493982 creator A5049847028 @default.
- W2767493982 creator A5054890754 @default.
- W2767493982 date "2017-11-01" @default.
- W2767493982 modified "2023-10-13" @default.
- W2767493982 title "Evolution of a Geriatric Syndrome: Pathophysiology and Treatment of Heart Failure with Preserved Ejection Fraction" @default.
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