Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767500852> ?p ?o ?g. }
- W2767500852 abstract "Simocyclinones are antibiotics produced by Streptomyces and Kitasatospora species that inhibit the validated drug target DNA gyrase in a unique way, and they are thus of therapeutic interest. Structural approaches have revealed their mode of action, the inducible-efflux mechanism in the producing organism, and given insight into one step in their biosynthesis. The crystal structures of simocyclinones bound to their target (gyrase), the transcriptional repressor SimR and the biosynthetic enzyme SimC7 reveal fascinating insight into how molecular recognition is achieved with these three unrelated proteins." @default.
- W2767500852 created "2017-11-17" @default.
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- W2767500852 date "2017-11-08" @default.
- W2767500852 modified "2023-09-23" @default.
- W2767500852 title "Structural insights into simocyclinone as an antibiotic, effector ligand and substrate" @default.
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- W2767500852 doi "https://doi.org/10.1093/femsre/fux055" @default.
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