FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767502297> ?p ?o ?g. }

• W2767502297 abstract "In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI and NMRS) have been used more systematically as outcome measures in natural history and clinical trial studies for Duchenne muscular dystrophy (DMD). Whereas most of these studies have emphasized the evaluation of the fat fraction as an assessment for disease severity, less focus has been placed on metabolic indices measured by NMRS. 31 P NMRS in DMD reveals an alkaline inorganic phosphate (P i ) pool, originating from either leaky dystrophic myocytes or an increased interstitial space. 1 H NMRS, exploiting the pH‐sensitive proton resonances of carnosine, an intracellular dipeptide, was used to distinguish between these two hypotheses. NMR data were obtained in 23 patients with DMD and 14 healthy subjects on a 3‐T clinical NMR system. Both 31 P and 1 H NMRS data were acquired at the level of the gastrocnemius medialis muscle. A multi‐slice multi‐echo imaging acquisition was performed for the determination of water T 2 and fat fraction in the same region of interest. Whereas nearly all patients with DMD showed an elevated pH compared with healthy controls when using 31 P NMRS, 1 H NMRS‐determined pH was not systematically increased. As expected, the carnosine‐based intracellular pH was never found to be alkaline in the absence of a concurrent P i ‐based pH elevation. In addition, abnormal intracellular pH, based on carnosine, was never associated with normal water T 2 values. We conclude that, in one group of patients, both 1 H and 31 P NMRS showed an alkaline pH, originating from the intracellular compartment and reflecting ionic dysregulation in dystrophic myocytes. In the other patients with DMD, intracellular pH was normal, but an alkaline P i pool was still present, suggesting an extracellular origin, probably revealing an expanded interstitial volume fraction, often associated with fibrotic changes. The data demonstrate that 1 H NMRS could serve as a biomarker to assess the normalization of intramyocytic pH and sarcolemmal permeability following therapy inducing dystrophin expression in patients with DMD." @default.
• W2767502297 created "2017-11-17" @default.
• W2767502297 creator A5065174778 @default.
• W2767502297 creator A5067574225 @default.
• W2767502297 creator A5075931186 @default.
• W2767502297 date "2017-11-12" @default.
• W2767502297 modified "2023-10-18" @default.
• W2767502297 title "¹H NMRS of carnosine combined with³¹P NMRS to better characterize skeletal muscle pH dysregulation in Duchenne muscular dystrophy" @default.
• W2767502297 cites W1499895366 @default.
• W2767502297 cites W1559691988 @default.
• W2767502297 cites W1573099362 @default.
• W2767502297 cites W1585579342 @default.
• W2767502297 cites W1781922193 @default.
• W2767502297 cites W1936873203 @default.
• W2767502297 cites W1974256573 @default.
• W2767502297 cites W1975139695 @default.
• W2767502297 cites W1976641996 @default.
• W2767502297 cites W1977923285 @default.
• W2767502297 cites W1985527232 @default.
• W2767502297 cites W1987439191 @default.
• W2767502297 cites W1987789988 @default.
• W2767502297 cites W1999317063 @default.
• W2767502297 cites W2001242302 @default.
• W2767502297 cites W2001604199 @default.
• W2767502297 cites W2003540356 @default.
• W2767502297 cites W2015985405 @default.
• W2767502297 cites W2017306120 @default.
• W2767502297 cites W2018069959 @default.
• W2767502297 cites W2028477639 @default.
• W2767502297 cites W2032398667 @default.
• W2767502297 cites W2037541448 @default.
• W2767502297 cites W2038428739 @default.
• W2767502297 cites W2040456345 @default.
• W2767502297 cites W2042796789 @default.
• W2767502297 cites W2057239114 @default.
• W2767502297 cites W2064741582 @default.
• W2767502297 cites W2066180106 @default.
• W2767502297 cites W2067758151 @default.
• W2767502297 cites W2068931539 @default.
• W2767502297 cites W2074597525 @default.
• W2767502297 cites W2081089173 @default.
• W2767502297 cites W2108034706 @default.
• W2767502297 cites W2111370164 @default.
• W2767502297 cites W2116279332 @default.
• W2767502297 cites W2120501091 @default.
• W2767502297 cites W2120773936 @default.
• W2767502297 cites W2121133511 @default.
• W2767502297 cites W2123134827 @default.
• W2767502297 cites W2128952479 @default.
• W2767502297 cites W2140857334 @default.
• W2767502297 cites W2141407712 @default.
• W2767502297 cites W2149551991 @default.
• W2767502297 cites W2151783154 @default.
• W2767502297 cites W2169365167 @default.
• W2767502297 cites W2172191780 @default.
• W2767502297 cites W2263406839 @default.
• W2767502297 cites W2277280343 @default.
• W2767502297 cites W2492111900 @default.
• W2767502297 cites W2517949748 @default.
• W2767502297 cites W2521874400 @default.
• W2767502297 cites W2554285001 @default.
• W2767502297 doi "https://doi.org/10.1002/nbm.3839" @default.
• W2767502297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29130550" @default.
• W2767502297 hasPublicationYear "2017" @default.
• W2767502297 type Work @default.
• W2767502297 sameAs 2767502297 @default.
• W2767502297 citedByCount "15" @default.
• W2767502297 countsByYear W27675022972019 @default.
• W2767502297 countsByYear W27675022972020 @default.
• W2767502297 countsByYear W27675022972021 @default.
• W2767502297 countsByYear W27675022972022 @default.
• W2767502297 crossrefType "journal-article" @default.
• W2767502297 hasAuthorship W2767502297A5065174778 @default.
• W2767502297 hasAuthorship W2767502297A5067574225 @default.
• W2767502297 hasAuthorship W2767502297A5075931186 @default.
• W2767502297 hasConcept C121332964 @default.
• W2767502297 hasConcept C126322002 @default.
• W2767502297 hasConcept C134018914 @default.
• W2767502297 hasConcept C134897140 @default.
• W2767502297 hasConcept C185592680 @default.
• W2767502297 hasConcept C2778943923 @default.
• W2767502297 hasConcept C2779030066 @default.
• W2767502297 hasConcept C2780687331 @default.
• W2767502297 hasConcept C46141821 @default.
• W2767502297 hasConcept C55493867 @default.
• W2767502297 hasConcept C71924100 @default.
• W2767502297 hasConcept C79879829 @default.
• W2767502297 hasConceptScore W2767502297C121332964 @default.
• W2767502297 hasConceptScore W2767502297C126322002 @default.
• W2767502297 hasConceptScore W2767502297C134018914 @default.
• W2767502297 hasConceptScore W2767502297C134897140 @default.
• W2767502297 hasConceptScore W2767502297C185592680 @default.
• W2767502297 hasConceptScore W2767502297C2778943923 @default.
• W2767502297 hasConceptScore W2767502297C2779030066 @default.
• W2767502297 hasConceptScore W2767502297C2780687331 @default.
• W2767502297 hasConceptScore W2767502297C46141821 @default.
• W2767502297 hasConceptScore W2767502297C55493867 @default.
• W2767502297 hasConceptScore W2767502297C71924100 @default.
• W2767502297 hasConceptScore W2767502297C79879829 @default.
• W2767502297 hasIssue "1" @default.

• next