Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767505989> ?p ?o ?g. }
- W2767505989 abstract "The transcription co-activator complex SAGA is recruited to gene promoters by sequence-specific transcriptional activators and by chromatin modifications to promote pre-initiation complex formation. The yeast Tra1 subunit is the major target of acidic activators such as Gal4, VP16, or Gcn4 but little is known about its structural organization. The 430 kDa Tra1 subunit and its human homolog the transformation/transcription domain-associated protein TRRAP are members of the phosphatidyl 3-kinase-related kinase (PIKK) family. Here, we present the cryo-EM structure of the entire SAGA complex where the major target of activator binding, the 430 kDa Tra1 protein, is resolved with an average resolution of 5.7 Å. The high content of alpha-helices in Tra1 enabled tracing of the majority of its main chain. Our results highlight the integration of Tra1 within the major epigenetic regulator SAGA." @default.
- W2767505989 created "2017-11-17" @default.
- W2767505989 creator A5012113257 @default.
- W2767505989 creator A5019340034 @default.
- W2767505989 creator A5021610094 @default.
- W2767505989 creator A5026727795 @default.
- W2767505989 creator A5052498269 @default.
- W2767505989 creator A5057389478 @default.
- W2767505989 creator A5059010642 @default.
- W2767505989 creator A5079050060 @default.
- W2767505989 creator A5085012980 @default.
- W2767505989 date "2017-11-16" @default.
- W2767505989 modified "2023-10-18" @default.
- W2767505989 title "Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA" @default.
- W2767505989 cites W1876329184 @default.
- W2767505989 cites W1968029309 @default.
- W2767505989 cites W1984124996 @default.
- W2767505989 cites W1986830781 @default.
- W2767505989 cites W1987577420 @default.
- W2767505989 cites W1989277636 @default.
- W2767505989 cites W2005781563 @default.
- W2767505989 cites W2006158980 @default.
- W2767505989 cites W2007107624 @default.
- W2767505989 cites W2011665065 @default.
- W2767505989 cites W2013729196 @default.
- W2767505989 cites W2029476353 @default.
- W2767505989 cites W2037549849 @default.
- W2767505989 cites W2037579319 @default.
- W2767505989 cites W2048912210 @default.
- W2767505989 cites W2048916500 @default.
- W2767505989 cites W2055043387 @default.
- W2767505989 cites W2058613034 @default.
- W2767505989 cites W2073895233 @default.
- W2767505989 cites W2074252380 @default.
- W2767505989 cites W2076634850 @default.
- W2767505989 cites W2083986528 @default.
- W2767505989 cites W2086812659 @default.
- W2767505989 cites W2095771622 @default.
- W2767505989 cites W2099826949 @default.
- W2767505989 cites W2103850692 @default.
- W2767505989 cites W2109054128 @default.
- W2767505989 cites W2114425916 @default.
- W2767505989 cites W2120772351 @default.
- W2767505989 cites W2124026197 @default.
- W2767505989 cites W2132109794 @default.
- W2767505989 cites W2132629607 @default.
- W2767505989 cites W2145138555 @default.
- W2767505989 cites W2146724295 @default.
- W2767505989 cites W2161138122 @default.
- W2767505989 cites W2162800127 @default.
- W2767505989 cites W2165364443 @default.
- W2767505989 cites W2168180694 @default.
- W2767505989 cites W2168365185 @default.
- W2767505989 cites W2173732482 @default.
- W2767505989 cites W2207318443 @default.
- W2767505989 cites W2258912434 @default.
- W2767505989 cites W2288234278 @default.
- W2767505989 cites W2336647682 @default.
- W2767505989 cites W2552310023 @default.
- W2767505989 cites W2585951574 @default.
- W2767505989 cites W2593511418 @default.
- W2767505989 cites W2950967305 @default.
- W2767505989 cites W2953320394 @default.
- W2767505989 doi "https://doi.org/10.1038/s41467-017-01564-7" @default.
- W2767505989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5691046" @default.
- W2767505989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29146944" @default.
- W2767505989 hasPublicationYear "2017" @default.
- W2767505989 type Work @default.
- W2767505989 sameAs 2767505989 @default.
- W2767505989 citedByCount "36" @default.
- W2767505989 countsByYear W27675059892018 @default.
- W2767505989 countsByYear W27675059892019 @default.
- W2767505989 countsByYear W27675059892020 @default.
- W2767505989 countsByYear W27675059892021 @default.
- W2767505989 countsByYear W27675059892022 @default.
- W2767505989 countsByYear W27675059892023 @default.
- W2767505989 crossrefType "journal-article" @default.
- W2767505989 hasAuthorship W2767505989A5012113257 @default.
- W2767505989 hasAuthorship W2767505989A5019340034 @default.
- W2767505989 hasAuthorship W2767505989A5021610094 @default.
- W2767505989 hasAuthorship W2767505989A5026727795 @default.
- W2767505989 hasAuthorship W2767505989A5052498269 @default.
- W2767505989 hasAuthorship W2767505989A5057389478 @default.
- W2767505989 hasAuthorship W2767505989A5059010642 @default.
- W2767505989 hasAuthorship W2767505989A5079050060 @default.
- W2767505989 hasAuthorship W2767505989A5085012980 @default.
- W2767505989 hasBestOaLocation W27675059891 @default.
- W2767505989 hasConcept C101762097 @default.
- W2767505989 hasConcept C104292427 @default.
- W2767505989 hasConcept C104317684 @default.
- W2767505989 hasConcept C138885662 @default.
- W2767505989 hasConcept C150194340 @default.
- W2767505989 hasConcept C179926584 @default.
- W2767505989 hasConcept C27153228 @default.
- W2767505989 hasConcept C41895202 @default.
- W2767505989 hasConcept C54355233 @default.
- W2767505989 hasConcept C83640560 @default.
- W2767505989 hasConcept C86339819 @default.
- W2767505989 hasConcept C86803240 @default.
- W2767505989 hasConcept C88045685 @default.