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- W2767509882 abstract "The highly stereocontrolled de novo synthesis of l-NBDNJ (the unnatural enantiomer of the iminosugar drug Miglustat) and a preliminary evaluation of its chaperoning potential are herein reported. l-NBDNJ is able to enhance lysosomal α-glucosidase levels in Pompe disease fibroblasts, either when administered singularly or when coincubated with the recombinant human α-glucosidase. In addition, differently from its d-enantiomer, l-NBDNJ does not act as a glycosidase inhibitor." @default.
- W2767509882 created "2017-11-17" @default.
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- W2767509882 date "2017-11-22" @default.
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- W2767509882 title "<i>N</i>-Butyl-<scp>l</scp>-deoxynojirimycin (<scp>l</scp>-NBDNJ): Synthesis of an Allosteric Enhancer of α-Glucosidase Activity for the Treatment of Pompe Disease" @default.
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- W2767509882 doi "https://doi.org/10.1021/acs.jmedchem.7b00646" @default.
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