FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767518162> ?p ?o ?g. }

• W2767518162 endingPage "1416" @default.
• W2767518162 startingPage "1403" @default.
• W2767518162 abstract "Accumulating data support a role for bioactive lipids as mediators of lipotixicity in cardiomyocytes. One class of these, the ceramides, constitutes a family of molecules that differ in structure and are synthesized by distinct enzymes, ceramide synthase (CerS)1-CerS6. Data support that specific ceramides and the enzymes that catalyze their formation play distinct roles in cell function. In a mouse model of diabetic cardiomyopathy, sphingolipid profiling revealed increases in not only the CerS5-derived ceramides but also in very long chain (VLC) ceramides derived from CerS2. Overexpression of CerS2 elevated VLC ceramides caused insulin resistance, oxidative stress, mitochondrial dysfunction, and mitophagy. Palmitate induced CerS2 and oxidative stress, mitophagy, and apoptosis, which were prevented by depletion of CerS2. Neither overexpression nor knockdown of CerS5 had any function in these processes, suggesting a chain-length dependent impact of ceramides on mitochondrial function. This concept was also supported by the observation that synthetic mitochondria-targeted ceramides led to mitophagy in a manner proportional to N-acyl chain length. Finally, blocking mitophagy exacerbated cell death. Taken together, our results support a model by which CerS2 and VLC ceramides have a distinct role in lipotoxicity, leading to mitochondrial damage, which results in subsequent adaptive mitophagy. Our data reveal a novel lipotoxic pathway through CerS2.-Law, B. A., Liao, X., Moore, K. S., Southard, A., Roddy, P., Ji, R., Szulc, Z., Bielawska, A., Schulze, P. C., Cowart, L. A. Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes." @default.
• W2767518162 created "2017-11-17" @default.
• W2767518162 creator A5009957103 @default.
• W2767518162 creator A5011475864 @default.
• W2767518162 creator A5018283700 @default.
• W2767518162 creator A5028663814 @default.
• W2767518162 creator A5038797261 @default.
• W2767518162 creator A5044737203 @default.
• W2767518162 creator A5053933342 @default.
• W2767518162 creator A5060886219 @default.
• W2767518162 creator A5061150717 @default.
• W2767518162 creator A5085365815 @default.
• W2767518162 date "2018-01-03" @default.
• W2767518162 modified "2023-10-17" @default.
• W2767518162 title "Lipotoxic very‐long‐chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes" @default.
• W2767518162 cites W1564511338 @default.
• W2767518162 cites W1581414531 @default.
• W2767518162 cites W1968192793 @default.
• W2767518162 cites W1970504457 @default.
• W2767518162 cites W1972253696 @default.
• W2767518162 cites W1972853687 @default.
• W2767518162 cites W1976761774 @default.
• W2767518162 cites W1978918501 @default.
• W2767518162 cites W1981224101 @default.
• W2767518162 cites W1985422114 @default.
• W2767518162 cites W1987320803 @default.
• W2767518162 cites W1989482880 @default.
• W2767518162 cites W1989832969 @default.
• W2767518162 cites W2002487087 @default.
• W2767518162 cites W2006033770 @default.
• W2767518162 cites W2007665059 @default.
• W2767518162 cites W2011419396 @default.
• W2767518162 cites W2011925577 @default.
• W2767518162 cites W2013765881 @default.
• W2767518162 cites W2020468088 @default.
• W2767518162 cites W2028834733 @default.
• W2767518162 cites W2030548258 @default.
• W2767518162 cites W2033782428 @default.
• W2767518162 cites W2036903182 @default.
• W2767518162 cites W2044325325 @default.
• W2767518162 cites W2045380458 @default.
• W2767518162 cites W2046230753 @default.
• W2767518162 cites W2051970831 @default.
• W2767518162 cites W2057158870 @default.
• W2767518162 cites W2059052888 @default.
• W2767518162 cites W2059421876 @default.
• W2767518162 cites W2061176979 @default.
• W2767518162 cites W2064868406 @default.
• W2767518162 cites W2065050042 @default.
• W2767518162 cites W2065186260 @default.
• W2767518162 cites W2069838096 @default.
• W2767518162 cites W2071789967 @default.
• W2767518162 cites W2072225072 @default.
• W2767518162 cites W2073115843 @default.
• W2767518162 cites W2073647995 @default.
• W2767518162 cites W2073656642 @default.
• W2767518162 cites W2077883552 @default.
• W2767518162 cites W2078702640 @default.
• W2767518162 cites W2094852633 @default.
• W2767518162 cites W2096189508 @default.
• W2767518162 cites W2101575450 @default.
• W2767518162 cites W2105094693 @default.
• W2767518162 cites W2109716633 @default.
• W2767518162 cites W2113863610 @default.
• W2767518162 cites W2115764880 @default.
• W2767518162 cites W2117820310 @default.
• W2767518162 cites W2119299191 @default.
• W2767518162 cites W2122530165 @default.
• W2767518162 cites W2123640306 @default.
• W2767518162 cites W2124966303 @default.
• W2767518162 cites W2128694891 @default.
• W2767518162 cites W2129601242 @default.
• W2767518162 cites W2134810505 @default.
• W2767518162 cites W2135687585 @default.
• W2767518162 cites W2138367727 @default.
• W2767518162 cites W2147382256 @default.
• W2767518162 cites W2148080571 @default.
• W2767518162 cites W2151582019 @default.
• W2767518162 cites W2154070747 @default.
• W2767518162 cites W2155325845 @default.
• W2767518162 cites W2161990266 @default.
• W2767518162 cites W2162092150 @default.
• W2767518162 cites W2165574517 @default.
• W2767518162 cites W2166788192 @default.
• W2767518162 cites W2318255226 @default.
• W2767518162 cites W2332053892 @default.
• W2767518162 cites W4253207208 @default.
• W2767518162 doi "https://doi.org/10.1096/fj.201700300r" @default.
• W2767518162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5892719" @default.
• W2767518162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29127192" @default.
• W2767518162 hasPublicationYear "2018" @default.
• W2767518162 type Work @default.
• W2767518162 sameAs 2767518162 @default.
• W2767518162 citedByCount "127" @default.
• W2767518162 countsByYear W27675181622018 @default.
• W2767518162 countsByYear W27675181622019 @default.
• W2767518162 countsByYear W27675181622020 @default.
• W2767518162 countsByYear W27675181622021 @default.

• next