FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767560462> ?p ?o ?g. }

• W2767560462 endingPage "838" @default.
• W2767560462 startingPage "828" @default.
• W2767560462 abstract "Diabetic nephropathy (DN) is characterized by a change of glomerular structure and dysfunction of filtration barrier, which significantly accompanied by podocytes apoptosis and glomerular fibrosis. Angiotensin Ⅱ(Ang Ⅱ) induced activation of ERK1/2 signaling plays important roles in causing apoptosis of podocytes in DN kidneys. Previous studies have shown that PRMT1 have a pro-inflammatory function through activating ERK1/2 signaling pathway during development of chronic pulmonary disease, however, its role in DN development has not been investigated. Here, we detected a higher expression of PRMT1 in podocytes of kidneys from DN patients compared with normal kidneys. High glucose administration induced elevation of PRMT1 expression in podocytes, accompanied with higher phosphorylation of ERK and cleaved caspase-3. AMI-1, a selective inhibitor for PRMT1, could block these effects caused by glucose treatment. Administration of AMI-1 also attenuated apoptosis of podocytes during DN development of high-fatty diet-induced diabetic mice. Epithelial to mesenchymal transition during DN development, which characterized by extracellular matrix deposition in podocytes, was also restrained by AMI-1 treatment. Collectively, this study firstly demonstrated that PRMT1 exert podocyte-injury effects in mouse glomerulus through Ang Ⅱ/ERK pathway, which reveals a potential therapeutic target for DN." @default.
• W2767560462 created "2017-11-17" @default.
• W2767560462 creator A5055377723 @default.
• W2767560462 date "2018-01-01" @default.
• W2767560462 modified "2023-10-13" @default.
• W2767560462 title "RETRACTED: PRMT1 mediates podocyte injury and glomerular fibrosis through phosphorylation of ERK pathway" @default.
• W2767560462 cites W1835190686 @default.
• W2767560462 cites W1975728241 @default.
• W2767560462 cites W1977761119 @default.
• W2767560462 cites W1977873599 @default.
• W2767560462 cites W1995873131 @default.
• W2767560462 cites W2024105041 @default.
• W2767560462 cites W2025312811 @default.
• W2767560462 cites W2044221879 @default.
• W2767560462 cites W2049769141 @default.
• W2767560462 cites W2051276221 @default.
• W2767560462 cites W2054225562 @default.
• W2767560462 cites W2054393454 @default.
• W2767560462 cites W2055298026 @default.
• W2767560462 cites W2062768506 @default.
• W2767560462 cites W2092809155 @default.
• W2767560462 cites W2100775121 @default.
• W2767560462 cites W2100829672 @default.
• W2767560462 cites W2116986223 @default.
• W2767560462 cites W2137979644 @default.
• W2767560462 cites W2141815936 @default.
• W2767560462 cites W2156211472 @default.
• W2767560462 cites W2160109224 @default.
• W2767560462 cites W2161396983 @default.
• W2767560462 cites W2164934883 @default.
• W2767560462 cites W2177131501 @default.
• W2767560462 cites W2218209996 @default.
• W2767560462 cites W2268531581 @default.
• W2767560462 cites W2336184425 @default.
• W2767560462 cites W2344237020 @default.
• W2767560462 cites W2602437944 @default.
• W2767560462 cites W4249404457 @default.
• W2767560462 cites W901067443 @default.
• W2767560462 doi "https://doi.org/10.1016/j.bbrc.2017.11.057" @default.
• W2767560462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29129692" @default.
• W2767560462 hasPublicationYear "2018" @default.
• W2767560462 type Work @default.
• W2767560462 sameAs 2767560462 @default.
• W2767560462 citedByCount "5" @default.
• W2767560462 countsByYear W27675604622018 @default.
• W2767560462 countsByYear W27675604622019 @default.
• W2767560462 countsByYear W27675604622023 @default.
• W2767560462 crossrefType "journal-article" @default.
• W2767560462 hasAuthorship W2767560462A5055377723 @default.
• W2767560462 hasConcept C11960822 @default.
• W2767560462 hasConcept C126322002 @default.
• W2767560462 hasConcept C134018914 @default.
• W2767560462 hasConcept C170493617 @default.
• W2767560462 hasConcept C185592680 @default.
• W2767560462 hasConcept C190283241 @default.
• W2767560462 hasConcept C2777146197 @default.
• W2767560462 hasConcept C2779561371 @default.
• W2767560462 hasConcept C2779922275 @default.
• W2767560462 hasConcept C2780091579 @default.
• W2767560462 hasConcept C2780559512 @default.
• W2767560462 hasConcept C2780819817 @default.
• W2767560462 hasConcept C2908929049 @default.
• W2767560462 hasConcept C502942594 @default.
• W2767560462 hasConcept C55493867 @default.
• W2767560462 hasConcept C57074206 @default.
• W2767560462 hasConcept C62478195 @default.
• W2767560462 hasConcept C71924100 @default.
• W2767560462 hasConcept C86803240 @default.
• W2767560462 hasConcept C95444343 @default.
• W2767560462 hasConceptScore W2767560462C11960822 @default.
• W2767560462 hasConceptScore W2767560462C126322002 @default.
• W2767560462 hasConceptScore W2767560462C134018914 @default.
• W2767560462 hasConceptScore W2767560462C170493617 @default.
• W2767560462 hasConceptScore W2767560462C185592680 @default.
• W2767560462 hasConceptScore W2767560462C190283241 @default.
• W2767560462 hasConceptScore W2767560462C2777146197 @default.
• W2767560462 hasConceptScore W2767560462C2779561371 @default.
• W2767560462 hasConceptScore W2767560462C2779922275 @default.
• W2767560462 hasConceptScore W2767560462C2780091579 @default.
• W2767560462 hasConceptScore W2767560462C2780559512 @default.
• W2767560462 hasConceptScore W2767560462C2780819817 @default.
• W2767560462 hasConceptScore W2767560462C2908929049 @default.
• W2767560462 hasConceptScore W2767560462C502942594 @default.
• W2767560462 hasConceptScore W2767560462C55493867 @default.
• W2767560462 hasConceptScore W2767560462C57074206 @default.
• W2767560462 hasConceptScore W2767560462C62478195 @default.
• W2767560462 hasConceptScore W2767560462C71924100 @default.
• W2767560462 hasConceptScore W2767560462C86803240 @default.
• W2767560462 hasConceptScore W2767560462C95444343 @default.
• W2767560462 hasFunder F4320321001 @default.
• W2767560462 hasIssue "1" @default.
• W2767560462 hasLocation W27675604621 @default.
• W2767560462 hasLocation W27675604622 @default.
• W2767560462 hasOpenAccess W2767560462 @default.
• W2767560462 hasPrimaryLocation W27675604621 @default.
• W2767560462 hasRelatedWork W2043556577 @default.
• W2767560462 hasRelatedWork W2053788713 @default.
• W2767560462 hasRelatedWork W2056562568 @default.

• next