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- W2767584643 abstract "Curcumin-loaded chitosan nanoparticles intended for transdermal delivery were successfully prepared, optimized and their fate, interaction and pathway through the skin were tracked. D-optimal response surface methodology was used for the nanoparticles optimization. Xy and z-stack confocal laser scanning microscopic images were used for the particles tracking after measuring the drug permeation through the skin using Franz diffusion cells. Very small particle sizes in the range of 33.85–199.23 nm accompanied with low PDI values of 0.129–0.536 of the prepared curcumin-loaded chitosan nanoparticles were obtained. TEM images revealed the spherical and non-aggregating curcumin-loaded chitosan nanoparticles. The ex-vivo permeation studies have proven the ability of the prepared chitosan nanoparticles to deliver curcumin through the skin reaching fluxes viz 5.14 ± 1.31 μg cm−2 h−1. The confocal laser scanning microscopy has proven that the appendageal route is the main route of penetration of the prepared nanoparticles and has demonstrated the localization of the chitosan nanoparticles within the hair follicles from which the drug diffuses to deep layers of the skin and beyond." @default.
- W2767584643 created "2017-11-17" @default.
- W2767584643 creator A5056827706 @default.
- W2767584643 creator A5066331800 @default.
- W2767584643 creator A5081934994 @default.
- W2767584643 date "2018-03-01" @default.
- W2767584643 modified "2023-10-14" @default.
- W2767584643 title "Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy" @default.
- W2767584643 cites W1813628317 @default.
- W2767584643 cites W1963918885 @default.
- W2767584643 cites W1964189315 @default.
- W2767584643 cites W1964501217 @default.
- W2767584643 cites W1966742874 @default.
- W2767584643 cites W1967665100 @default.
- W2767584643 cites W1971645600 @default.
- W2767584643 cites W1975530828 @default.
- W2767584643 cites W1976194786 @default.
- W2767584643 cites W1981347819 @default.
- W2767584643 cites W1981975619 @default.
- W2767584643 cites W1984641506 @default.
- W2767584643 cites W1984942385 @default.
- W2767584643 cites W1986228347 @default.
- W2767584643 cites W1986662944 @default.
- W2767584643 cites W1988980725 @default.
- W2767584643 cites W1994198706 @default.
- W2767584643 cites W1996231108 @default.
- W2767584643 cites W1997100704 @default.
- W2767584643 cites W1997393673 @default.
- W2767584643 cites W1998925312 @default.
- W2767584643 cites W2000294530 @default.
- W2767584643 cites W2000683502 @default.
- W2767584643 cites W2001536021 @default.
- W2767584643 cites W2007115130 @default.
- W2767584643 cites W2007591700 @default.
- W2767584643 cites W2009284487 @default.
- W2767584643 cites W2010845995 @default.
- W2767584643 cites W2011508670 @default.
- W2767584643 cites W2012373901 @default.
- W2767584643 cites W2012763530 @default.
- W2767584643 cites W2015731158 @default.
- W2767584643 cites W2019984347 @default.
- W2767584643 cites W2021106922 @default.
- W2767584643 cites W2021124448 @default.
- W2767584643 cites W2023283179 @default.
- W2767584643 cites W2026226329 @default.
- W2767584643 cites W2027833950 @default.
- W2767584643 cites W2033209275 @default.
- W2767584643 cites W2034805293 @default.
- W2767584643 cites W2036239088 @default.
- W2767584643 cites W2037007927 @default.
- W2767584643 cites W2044645880 @default.
- W2767584643 cites W2045456307 @default.
- W2767584643 cites W2045588696 @default.
- W2767584643 cites W2046806170 @default.
- W2767584643 cites W2047892618 @default.
- W2767584643 cites W2048072806 @default.
- W2767584643 cites W2049949169 @default.
- W2767584643 cites W2051292995 @default.
- W2767584643 cites W2052218150 @default.
- W2767584643 cites W2052714733 @default.
- W2767584643 cites W2055989866 @default.
- W2767584643 cites W2057437898 @default.
- W2767584643 cites W2059026836 @default.
- W2767584643 cites W2064975624 @default.
- W2767584643 cites W2065448687 @default.
- W2767584643 cites W2071147039 @default.
- W2767584643 cites W2071288758 @default.
- W2767584643 cites W2073781106 @default.
- W2767584643 cites W2075151979 @default.
- W2767584643 cites W2075496018 @default.
- W2767584643 cites W2077431908 @default.
- W2767584643 cites W2077619816 @default.
- W2767584643 cites W2078120079 @default.
- W2767584643 cites W2079002574 @default.
- W2767584643 cites W2080430067 @default.
- W2767584643 cites W2085236106 @default.
- W2767584643 cites W208587536 @default.
- W2767584643 cites W2087731154 @default.
- W2767584643 cites W2090429019 @default.
- W2767584643 cites W2094046366 @default.
- W2767584643 cites W2094788147 @default.
- W2767584643 cites W2096734499 @default.
- W2767584643 cites W2097249053 @default.
- W2767584643 cites W2102192655 @default.
- W2767584643 cites W2106169256 @default.
- W2767584643 cites W2114966142 @default.
- W2767584643 cites W2115276212 @default.
- W2767584643 cites W2115494253 @default.
- W2767584643 cites W2135861676 @default.
- W2767584643 cites W2144491599 @default.
- W2767584643 cites W2146363147 @default.
- W2767584643 cites W2148663802 @default.
- W2767584643 cites W2156156861 @default.
- W2767584643 cites W2161152672 @default.
- W2767584643 cites W2164632606 @default.
- W2767584643 cites W2201399244 @default.
- W2767584643 cites W2208716684 @default.
- W2767584643 cites W2238023223 @default.