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• W2767609178 abstract "Background/purpose The prognosis of patients with intermediate-risk neuroblastoma is favorable; therefore, a reduction therapy is desired. However, the long-term prognosis of those with residual tumor is unclear. The aim of this study was to clarify the necessity of residual tumor resection. Methods We retrospectively reviewed the records of patients diagnosed with intermediate-risk neuroblastoma who either were treated by chemotherapy only (nonresection group; n = 16), or received postchemotherapy tumor resection (resection group; n = 9). Results In the nonresection group, tumor size decreased in 14 patients; 5 had no detectable local tumor at the end of the follow-up period. Tumor size increased in 2 patients 1.5–2.5 years postchemotherapy. Both patients received additional treatment and survived. All patients survived during the median follow-up time of 127 months. In the resection group, 5 patients received complete resections and 4 patients received nearly complete resections. All patients survived during the median follow-up time of 84 months. In 8 out of 9 resected tumors, regression or maturation was pathologically induced by chemotherapy-only treatment. Conclusion Patients with intermediate-risk neuroblastoma with or without postchemotherapy residual tumor resection had an excellent long-term outcome. The tumor pathology with intermediate-risk neuroblastoma might be susceptible to change to regression or maturation by chemotherapy. Level of evidence IV" @default.
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• W2767609178 date "2018-09-01" @default.
• W2767609178 modified "2023-09-30" @default.
• W2767609178 title "Excellent prognosis of patients with intermediate-risk neuroblastoma and residual tumor postchemotherapy" @default.
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• W2767609178 doi "https://doi.org/10.1016/j.jpedsurg.2017.10.061" @default.
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