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• W2767631567 endingPage "7024" @default.
• W2767631567 startingPage "7003" @default.
• W2767631567 abstract "The selective expression of non-human genes in tumor tissue to activate non-toxic compounds (Gene Directed Prodrug Enzyme Therapy, GDEPT) is a novel strategy designed for killing tumor cells in patients with little or no systemic toxicity. Numerous non-human genes have been evaluated, but none have yet been successful in the clinic.Unlike human purine nucleoside phosphorylase (PNP), E. coli PNP accepts adenine containing nucleosides as substrates, and is therefore able to selectively activate non-toxic purine analogs in tumor tissue. Various in vitro and in vivo assays have been utilized to evaluate E. coli PNP as a potential activating enzyme.We and others have demonstrated excellent in vitro and in vivo anti-tumor activity with various GDEPT strategies utilizing E. coli PNP to activate purine nucleoside analogs. A phase I clinical trial utilizing recombinant adenoviral vector for delivery of E. coli PNP to solid tumors followed by systemic administration of fludarabine phosphate (NCT01310179; IND# 14271) has recently been completed. In this trial, significant anti-tumor activity was demonstrated with negligible toxicity related to the therapy. The mechanism of cell kill (inhibition of RNA and protein synthesis) is distinct from all currently used anticancer drugs and all experimental compounds under development. The approach has demonstrated excellent ability to kill neighboring tumor cells that do not express E. coli PNP, is active against non-proliferating and proliferating tumors cells (as well as tumor stem cells, stroma), and is therefore very effective against solid tumors with a low growth fraction.The unique attributes distinguish this approach from other GDEPT strategies and are precisely those required to mediate significant improvements in antitumor therapy." @default.
• W2767631567 created "2017-11-17" @default.
• W2767631567 creator A5050704941 @default.
• W2767631567 creator A5064978721 @default.
• W2767631567 date "2018-02-16" @default.
• W2767631567 modified "2023-10-13" @default.
• W2767631567 title "Use of E. coli Purine Nucleoside Phosphorylase in the Treatment of Solid Tumors" @default.
• W2767631567 cites W1498206925 @default.
• W2767631567 cites W1503350292 @default.
• W2767631567 cites W1526530838 @default.
• W2767631567 cites W1555297256 @default.
• W2767631567 cites W1569724479 @default.
• W2767631567 cites W1570457166 @default.
• W2767631567 cites W1570542714 @default.
• W2767631567 cites W1580143110 @default.
• W2767631567 cites W1925119874 @default.
• W2767631567 cites W1934167559 @default.
• W2767631567 cites W1940644011 @default.
• W2767631567 cites W1951574774 @default.
• W2767631567 cites W1965634162 @default.
• W2767631567 cites W1968373934 @default.
• W2767631567 cites W1969574428 @default.
• W2767631567 cites W1969781426 @default.
• W2767631567 cites W1970134736 @default.
• W2767631567 cites W1972699330 @default.
• W2767631567 cites W1973311702 @default.
• W2767631567 cites W1974013202 @default.
• W2767631567 cites W1978255835 @default.
• W2767631567 cites W1979056918 @default.
• W2767631567 cites W1983732987 @default.
• W2767631567 cites W1984704704 @default.
• W2767631567 cites W1985212348 @default.
• W2767631567 cites W1986482300 @default.
• W2767631567 cites W1992827089 @default.
• W2767631567 cites W1996925520 @default.
• W2767631567 cites W2000913845 @default.
• W2767631567 cites W2001881257 @default.
• W2767631567 cites W2004689817 @default.
• W2767631567 cites W2006732267 @default.
• W2767631567 cites W2007344686 @default.
• W2767631567 cites W2008670858 @default.
• W2767631567 cites W2008734787 @default.
• W2767631567 cites W2010201813 @default.
• W2767631567 cites W2010358436 @default.
• W2767631567 cites W2012873467 @default.
• W2767631567 cites W2014197413 @default.
• W2767631567 cites W2015136091 @default.
• W2767631567 cites W2015445088 @default.
• W2767631567 cites W2016928117 @default.
• W2767631567 cites W2016956375 @default.
• W2767631567 cites W2017710897 @default.
• W2767631567 cites W2018075506 @default.
• W2767631567 cites W2023896314 @default.
• W2767631567 cites W2027703570 @default.
• W2767631567 cites W2028008092 @default.
• W2767631567 cites W2028058584 @default.
• W2767631567 cites W2028122325 @default.
• W2767631567 cites W2032199781 @default.
• W2767631567 cites W2034698551 @default.
• W2767631567 cites W2035709206 @default.
• W2767631567 cites W2037589775 @default.
• W2767631567 cites W2040386556 @default.
• W2767631567 cites W2040834249 @default.
• W2767631567 cites W2044168424 @default.
• W2767631567 cites W2047212218 @default.
• W2767631567 cites W2049672183 @default.
• W2767631567 cites W2049762868 @default.
• W2767631567 cites W2058327184 @default.
• W2767631567 cites W2058966369 @default.
• W2767631567 cites W2059069412 @default.
• W2767631567 cites W2063360235 @default.
• W2767631567 cites W2065338657 @default.
• W2767631567 cites W2065756988 @default.
• W2767631567 cites W2067456403 @default.
• W2767631567 cites W2069034759 @default.
• W2767631567 cites W2070851085 @default.
• W2767631567 cites W2074708594 @default.
• W2767631567 cites W2079378100 @default.
• W2767631567 cites W2081947065 @default.
• W2767631567 cites W2084036141 @default.
• W2767631567 cites W2084760475 @default.
• W2767631567 cites W2087496288 @default.
• W2767631567 cites W2091771998 @default.
• W2767631567 cites W2092225533 @default.
• W2767631567 cites W2093743785 @default.
• W2767631567 cites W209377287 @default.
• W2767631567 cites W2094979671 @default.
• W2767631567 cites W2098072664 @default.
• W2767631567 cites W2109333550 @default.
• W2767631567 cites W2114795467 @default.
• W2767631567 cites W2118607669 @default.
• W2767631567 cites W2121380784 @default.
• W2767631567 cites W2122669405 @default.
• W2767631567 cites W2124372476 @default.
• W2767631567 cites W2124672376 @default.
• W2767631567 cites W2125610733 @default.
• W2767631567 cites W2126269666 @default.
• W2767631567 cites W2126594791 @default.

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