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• W2767674328 abstract "Uncoupling between ATP overflow and extracellular adenosine formation changes purinergic signaling in post-inflammatory ileitis. Adenosine neuromodulation deficits were ascribed to feed-forward inhibition of ecto-5'-nucleotidase/CD73 by high extracellular adenine nucleotides in the inflamed ileum. Here, we hypothesized that inflammation-induced changes in cellular density may also account to unbalance the release of purines and their influence on [3H]acetylcholine release from longitudinal muscle-myenteric plexus preparations of the ileum of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-treated rats. The population of S100β-positive glial cells increase, whereas Ano-1-positive interstitial cells of Cajal (ICCs) diminished, in the ileum 7-days after the inflammatory insult. In the absence of changes in the density of VAChT-positive cholinergic nerves detected by immunofluorescence confocal microscopy, the inflamed myenteric plexus released smaller amounts of [3H]acetylcholine which also became less sensitive to neuronal blockade by tetrodotoxin (1 μM). Instead, [3H]acetylcholine release was attenuated by sodium fluoroacetate (5 mM), carbenoxolone (10 μM) and A438079 (3 μM), which prevent activation of glial cells, pannexin-1 hemichannels and P2X7 receptors, respectively. Sodium fluoroacetate also decreased ATP overflow without significantly affecting the extracellular adenosine levels, thus indicating that surplus ATP release parallels reactive gliosis in post-inflammatory ileitis. Conversely, loss of ICCs may explain the lower amounts of adenosine detected in TNBS-treated preparations, since blockade of Cav3 (T-type) channels existing in ICCs with mibefradil (3 μM) or inhibition of the equilibrative nucleoside transporter 1 with dipyridamole (0.5 μM), both decreased extracellular adenosine. Data indicate that post-inflammatory ileitis operates a shift on purinergic neuromodulation reflecting the upregulation of ATP-releasing enteric glial cells and the depletion of ICCs accounting for decreased adenosine overflow via equilibrative nucleoside transporters." @default.
• W2767674328 created "2017-11-17" @default.
• W2767674328 creator A5000881478 @default.
• W2767674328 creator A5001688753 @default.
• W2767674328 creator A5036695788 @default.
• W2767674328 creator A5050983457 @default.
• W2767674328 creator A5072709153 @default.
• W2767674328 creator A5086429134 @default.
• W2767674328 date "2017-11-08" @default.
• W2767674328 modified "2023-10-14" @default.
• W2767674328 title "Post-inflammatory Ileitis Induces Non-neuronal Purinergic Signaling Adjustments of Cholinergic Neurotransmission in the Myenteric Plexus" @default.
• W2767674328 cites W1492340080 @default.
• W2767674328 cites W1518095394 @default.
• W2767674328 cites W1555431931 @default.
• W2767674328 cites W1556555719 @default.
• W2767674328 cites W1560476382 @default.
• W2767674328 cites W1576754558 @default.
• W2767674328 cites W1606035672 @default.
• W2767674328 cites W1611735695 @default.
• W2767674328 cites W1655510660 @default.
• W2767674328 cites W1725475117 @default.
• W2767674328 cites W1769687268 @default.
• W2767674328 cites W1771649680 @default.
• W2767674328 cites W177501044 @default.
• W2767674328 cites W1817342809 @default.
• W2767674328 cites W1835264028 @default.
• W2767674328 cites W186660767 @default.
• W2767674328 cites W1896587953 @default.
• W2767674328 cites W1903407475 @default.
• W2767674328 cites W1916800927 @default.
• W2767674328 cites W1964157347 @default.
• W2767674328 cites W1964988229 @default.
• W2767674328 cites W1966927485 @default.
• W2767674328 cites W1966988326 @default.
• W2767674328 cites W1969485182 @default.
• W2767674328 cites W1969619562 @default.
• W2767674328 cites W1972199876 @default.
• W2767674328 cites W1974360723 @default.
• W2767674328 cites W1983035713 @default.
• W2767674328 cites W1983865000 @default.
• W2767674328 cites W1990355430 @default.
• W2767674328 cites W1993374742 @default.
• W2767674328 cites W1994643044 @default.
• W2767674328 cites W1995788380 @default.
• W2767674328 cites W1999564947 @default.
• W2767674328 cites W1999705526 @default.
• W2767674328 cites W1999847499 @default.
• W2767674328 cites W2002798901 @default.
• W2767674328 cites W2002923063 @default.
• W2767674328 cites W2005441636 @default.
• W2767674328 cites W2005900188 @default.
• W2767674328 cites W2011130102 @default.
• W2767674328 cites W2014847032 @default.
• W2767674328 cites W2017008588 @default.
• W2767674328 cites W2017708435 @default.
• W2767674328 cites W2019440784 @default.
• W2767674328 cites W2022548397 @default.
• W2767674328 cites W2025173043 @default.
• W2767674328 cites W2027699773 @default.
• W2767674328 cites W2029878445 @default.
• W2767674328 cites W2030901666 @default.
• W2767674328 cites W2032123628 @default.
• W2767674328 cites W2033392953 @default.
• W2767674328 cites W2033840433 @default.
• W2767674328 cites W2035250169 @default.
• W2767674328 cites W2035980303 @default.
• W2767674328 cites W2038206572 @default.
• W2767674328 cites W2045374278 @default.
• W2767674328 cites W2046464324 @default.
• W2767674328 cites W2046984200 @default.
• W2767674328 cites W2048143272 @default.
• W2767674328 cites W2048154230 @default.
• W2767674328 cites W2048218292 @default.
• W2767674328 cites W2051057929 @default.
• W2767674328 cites W2051573920 @default.
• W2767674328 cites W2052089708 @default.
• W2767674328 cites W2053848299 @default.
• W2767674328 cites W2054264840 @default.
• W2767674328 cites W2055692928 @default.
• W2767674328 cites W2057411366 @default.
• W2767674328 cites W2059931557 @default.
• W2767674328 cites W2063601395 @default.
• W2767674328 cites W2067922230 @default.
• W2767674328 cites W2069714379 @default.
• W2767674328 cites W2071712317 @default.
• W2767674328 cites W2072950950 @default.
• W2767674328 cites W2074137875 @default.
• W2767674328 cites W2074273899 @default.
• W2767674328 cites W2074274384 @default.
• W2767674328 cites W2075124455 @default.
• W2767674328 cites W2077656589 @default.
• W2767674328 cites W2077962076 @default.
• W2767674328 cites W2089597910 @default.
• W2767674328 cites W2090573001 @default.
• W2767674328 cites W2093846062 @default.
• W2767674328 cites W2096551301 @default.
• W2767674328 cites W2096979751 @default.
• W2767674328 cites W2102694854 @default.
• W2767674328 cites W2104524918 @default.
• W2767674328 cites W2106924574 @default.

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