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• W2767679438 abstract "// Chong Jie 1, 2 , Zhuo Luo 1, 2 , Huan Chen 1, 2 , Min Wang 3 , Chang Yan 1, 2 , Zhong-Fu Mao 1, 2 , Gao-Keng Xiao 2 , Hiroshi Kurihara 1, 2 , Yi-Fang Li 1, 2 and Rong-Rong He 1, 2 1 Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou 510632, China 2 Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, China 3 Department of Pharmacy, Hainan General Hospital, Hainan 570311, China Correspondence to: Rong-Rong He, email: rongronghe@jnu.edu.cn Yi-Fang Li, email: liyifang706@jnu.edu.cn Hiroshi Kurihara, email: Kurihara_hiroshi@163.com Keywords: indirubin; influenza virus; virus susceptibility; MAVS; STING Received: February 25, 2017      Accepted: July 18, 2017      Published: November 09, 2017 ABSTRACT Isatis indigotica has a long history in treating virus infection and related symptoms in China. Nevertheless, its antivirus evidence in animal studies is not satisfactory, which might be due to the lack of appropriate animal model. Previously, we had utilized restraint stress to establish mouse H1N1 susceptibility model which was helpful in evaluating the anti-virus effect of medicines targeting host factors, such as type I interferon production. In this study, this model was employed to investigate the effect and mechanism of indirubin, a natural bisindole alkaloid from Isatis indigotica , on influenza A virus susceptibility. In the in vitro study, the stress hormone corticosterone was used to simulate restraint stress. Our results demonstrated that indirubin decreased the susceptibility to influenza virus with lowered mortality and alleviated lung damage in restraint-stressed mice model. Moreover, indirubin promoted the expression of interferon-β and interferon inducible transmembrane 3. In addition, indirubin maintained the morphology and function of mitochondria following influenza A virus infection. Further study revealed that indirubin promoted interferon-β production through promoting mitochondrial antiviral signaling pathway. Our study indicated that indirubin could be a candidate for the therapy of influenza." @default.
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• W2767679438 date "2017-11-09" @default.
• W2767679438 modified "2023-10-18" @default.
• W2767679438 title "Indirubin, a bisindole alkaloid from <i>Isatis indigotica</i>, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling" @default.
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• W2767679438 doi "https://doi.org/10.18632/oncotarget.22350" @default.
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