Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767701229> ?p ?o ?g. }
- W2767701229 endingPage "475" @default.
- W2767701229 startingPage "465" @default.
- W2767701229 abstract "In spite of their widespread use, toxicity of silica nanoparticles (SiO2 NPs) to mammalian has not been extensively investigated. In the present study, it is aimed to investigate the effects and the mechanism of action of 20 nm sized SiO2 NPs on isolated uterine smooth muscle. A total number of 84 preparations of uterine strips were used in the experiments. Study was designed as four groups: group I (control), group II (0.2 mM SiO2 NPs), group III (0.4 mM SiO2 NPs) and group IV (0.8 mM SiO2 NPs). Spontaneous contractions were recorded using mechanical activity recording system. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) levels were measured using the spectrophotometric methods. Apoptosis of the cells was detected using immunofluorescence staining assay. SiO2 NP distribution and ultrastructural changes were determined by transmission electron microscopy. In groups II–IV, the frequency of contraction was significantly lower than that of the group I, whereas the contraction energy significantly decreased only in group IV. SOD and GSH-Px activities were significantly lower in experimental groups compared to the control group. MDA level and apoptotic cells were significantly higher in all SiO2 groups compared to the control group. Numerous SiO2 NPs in cytoplasm and connective tissue were observed in all dose groups. These findings showed that 20 nm sized SiO2 NPs enter the connective tissue and cytoplasm of uterine muscle cells and cause oxidative stress and apoptosis leading to impaired uterine contractile activity." @default.
- W2767701229 created "2017-11-17" @default.
- W2767701229 creator A5012195666 @default.
- W2767701229 creator A5015150123 @default.
- W2767701229 creator A5026009595 @default.
- W2767701229 creator A5026955178 @default.
- W2767701229 creator A5037995126 @default.
- W2767701229 creator A5045101428 @default.
- W2767701229 creator A5057303740 @default.
- W2767701229 creator A5066361609 @default.
- W2767701229 creator A5076145267 @default.
- W2767701229 creator A5091534079 @default.
- W2767701229 date "2017-11-08" @default.
- W2767701229 modified "2023-10-16" @default.
- W2767701229 title "Effects of silica nanoparticles on isolated rat uterine smooth muscle" @default.
- W2767701229 cites W126254314 @default.
- W2767701229 cites W1489889146 @default.
- W2767701229 cites W1579782115 @default.
- W2767701229 cites W1603407576 @default.
- W2767701229 cites W1775749144 @default.
- W2767701229 cites W1968283122 @default.
- W2767701229 cites W1968503053 @default.
- W2767701229 cites W1973240521 @default.
- W2767701229 cites W1982129714 @default.
- W2767701229 cites W1998678158 @default.
- W2767701229 cites W2014707504 @default.
- W2767701229 cites W2018392526 @default.
- W2767701229 cites W2018979536 @default.
- W2767701229 cites W2023226705 @default.
- W2767701229 cites W2033473289 @default.
- W2767701229 cites W2037291605 @default.
- W2767701229 cites W2055826631 @default.
- W2767701229 cites W2056202999 @default.
- W2767701229 cites W2057313063 @default.
- W2767701229 cites W2057401811 @default.
- W2767701229 cites W2070032426 @default.
- W2767701229 cites W2074438151 @default.
- W2767701229 cites W2077537727 @default.
- W2767701229 cites W2079057977 @default.
- W2767701229 cites W2087540413 @default.
- W2767701229 cites W2102618395 @default.
- W2767701229 cites W2106624277 @default.
- W2767701229 cites W2120552851 @default.
- W2767701229 cites W2123505414 @default.
- W2767701229 cites W2140906896 @default.
- W2767701229 cites W2159305277 @default.
- W2767701229 cites W2164363376 @default.
- W2767701229 cites W2186603084 @default.
- W2767701229 cites W2294597441 @default.
- W2767701229 cites W2404827672 @default.
- W2767701229 cites W2526755011 @default.
- W2767701229 cites W2530784749 @default.
- W2767701229 cites W2548332406 @default.
- W2767701229 cites W2565685852 @default.
- W2767701229 cites W2573399996 @default.
- W2767701229 cites W2582541320 @default.
- W2767701229 cites W2588907656 @default.
- W2767701229 cites W2590983796 @default.
- W2767701229 doi "https://doi.org/10.1080/01480545.2017.1384005" @default.
- W2767701229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29115178" @default.
- W2767701229 hasPublicationYear "2017" @default.
- W2767701229 type Work @default.
- W2767701229 sameAs 2767701229 @default.
- W2767701229 citedByCount "8" @default.
- W2767701229 countsByYear W27677012292020 @default.
- W2767701229 countsByYear W27677012292021 @default.
- W2767701229 countsByYear W27677012292022 @default.
- W2767701229 countsByYear W27677012292023 @default.
- W2767701229 crossrefType "journal-article" @default.
- W2767701229 hasAuthorship W2767701229A5012195666 @default.
- W2767701229 hasAuthorship W2767701229A5015150123 @default.
- W2767701229 hasAuthorship W2767701229A5026009595 @default.
- W2767701229 hasAuthorship W2767701229A5026955178 @default.
- W2767701229 hasAuthorship W2767701229A5037995126 @default.
- W2767701229 hasAuthorship W2767701229A5045101428 @default.
- W2767701229 hasAuthorship W2767701229A5057303740 @default.
- W2767701229 hasAuthorship W2767701229A5066361609 @default.
- W2767701229 hasAuthorship W2767701229A5076145267 @default.
- W2767701229 hasAuthorship W2767701229A5091534079 @default.
- W2767701229 hasConcept C126322002 @default.
- W2767701229 hasConcept C134018914 @default.
- W2767701229 hasConcept C142724271 @default.
- W2767701229 hasConcept C153911025 @default.
- W2767701229 hasConcept C163415756 @default.
- W2767701229 hasConcept C16685009 @default.
- W2767701229 hasConcept C181199279 @default.
- W2767701229 hasConcept C185592680 @default.
- W2767701229 hasConcept C190283241 @default.
- W2767701229 hasConcept C2775838275 @default.
- W2767701229 hasConcept C2776151105 @default.
- W2767701229 hasConcept C2776766599 @default.
- W2767701229 hasConcept C2778401633 @default.
- W2767701229 hasConcept C2778760513 @default.
- W2767701229 hasConcept C2779066055 @default.
- W2767701229 hasConcept C518705261 @default.
- W2767701229 hasConcept C538909803 @default.
- W2767701229 hasConcept C55493867 @default.
- W2767701229 hasConcept C71924100 @default.