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- W2767701752 abstract "Nitric Oxide (NO), a potent vasodilator and vital signaling molecule, has been shown to contribute to the regulation of glomerular ultrafiltration. However, whether changes in NO occur in podocytes during the pathogenesis of salt-sensitive hypertension has not yet been thoroughly examined. We showed here that podocytes produce NO, and further hypothesized that hypertensive animals would exhibit reduced NO production in these cells in response to various paracrine factors, which might contribute to the damage of glomeruli filtration barrier and development of proteinuria. To test this, we isolated glomeruli from the kidneys of Dahl salt-sensitive (SS) rats fed a low salt (LS; 0.4% NaCl) or high salt (HS; 4% NaCl, 3 weeks) diets and loaded podocytes with either a combination of NO and Ca2+ fluorophores (DAF-FM and Fura Red, respectively) or DAF-FM alone. Changes in fluorescence were observed with confocal microscopy in response to adenosine triphosphate (ATP), angiotensin II (Ang II), and hydrogen peroxide (H2O2). Application of Ang II resulted in activation of both NO and intracellular calcium ([Ca2+]i) transients. In contrast, ATP promoted [Ca2+]i transients, but did not have any effects on NO production. SS rats fed a HS diet for 3 weeks demonstrated impaired NO production: the response to Ang II or H2O2 in podocytes of glomeruli isolated from SS rats fed a HS diet was significantly reduced compared to rats fed a LS diet. Therefore, glomerular podocytes from hypertensive rats showed a diminished NO release in response to Ang II or oxidative stress, suggesting that podocytic NO signaling is dysfunctional in this condition and likely contributes to the development of kidney injury." @default.
- W2767701752 created "2017-11-17" @default.
- W2767701752 creator A5002899728 @default.
- W2767701752 creator A5005174825 @default.
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- W2767701752 creator A5029250817 @default.
- W2767701752 creator A5031428652 @default.
- W2767701752 creator A5062936414 @default.
- W2767701752 date "2018-01-01" @default.
- W2767701752 modified "2023-10-17" @default.
- W2767701752 title "Nitric oxide production by glomerular podocytes" @default.
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- W2767701752 doi "https://doi.org/10.1016/j.niox.2017.11.005" @default.
- W2767701752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5776695" @default.