FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767721831> ?p ?o ?g. }

• W2767721831 endingPage "1699" @default.
• W2767721831 startingPage "1691" @default.
• W2767721831 abstract "Ongoing research suggests preliminary, though not entirely consistent, evidence of neural abnormalities in signalling prediction errors in schizophrenia. Supporting theories suggest mechanistic links between the disruption of these processes and the generation of psychotic symptoms. However, it is unknown at what stage in the pathogenesis of psychosis these impairments in prediction-error signalling develop. One major confound in prior studies is the use of medicated patients with strongly varying disease durations. Our study aims to investigate the involvement of the meso-cortico-striatal circuitry during reward prediction-error signalling in earliest stages of psychosis. We studied patients with first-episode psychosis (FEP) and help-seeking individuals at-risk for psychosis due to sub-threshold prodromal psychotic symptoms. Patients with either FEP (n = 14), or at-risk for developing psychosis (n = 30), and healthy volunteers (n = 39) performed a reinforcement learning task during fMRI scanning. ANOVA revealed significant (p < 0.05 family-wise error corrected) prediction-error signalling differences between groups in the dopaminergic midbrain and right middle frontal gyrus (dorsolateral prefrontal cortex, DLPFC). FEP patients showed disrupted reward prediction-error signalling compared to controls in both regions. At-risk patients showed intermediate activation in the midbrain that significantly differed from controls and from FEP patients, but DLPFC activation that did not differ from controls. Our study confirms that FEP patients have abnormal meso-cortical signalling of reward-prediction errors, whereas reward-prediction-error dysfunction in the at-risk patients appears to show a more nuanced pattern of activation with a degree of midbrain impairment but preserved cortical function." @default.
• W2767721831 created "2017-11-17" @default.
• W2767721831 creator A5012357143 @default.
• W2767721831 creator A5015205461 @default.
• W2767721831 creator A5020886846 @default.
• W2767721831 creator A5041538919 @default.
• W2767721831 creator A5043075118 @default.
• W2767721831 creator A5044059700 @default.
• W2767721831 creator A5058623167 @default.
• W2767721831 creator A5072392137 @default.
• W2767721831 date "2018-04-05" @default.
• W2767721831 modified "2023-10-05" @default.
• W2767721831 title "Abnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis" @default.
• W2767721831 cites W1503962455 @default.
• W2767721831 cites W1506537224 @default.
• W2767721831 cites W1608338497 @default.
• W2767721831 cites W1979025384 @default.
• W2767721831 cites W1985029200 @default.
• W2767721831 cites W1991975614 @default.
• W2767721831 cites W1992381398 @default.
• W2767721831 cites W1992545390 @default.
• W2767721831 cites W2011451766 @default.
• W2767721831 cites W2012007142 @default.
• W2767721831 cites W2014979870 @default.
• W2767721831 cites W2017709022 @default.
• W2767721831 cites W2020588526 @default.
• W2767721831 cites W2025681864 @default.
• W2767721831 cites W2025849517 @default.
• W2767721831 cites W2043214237 @default.
• W2767721831 cites W2046713808 @default.
• W2767721831 cites W2056112334 @default.
• W2767721831 cites W2063902973 @default.
• W2767721831 cites W2065540111 @default.
• W2767721831 cites W2068772097 @default.
• W2767721831 cites W2070461647 @default.
• W2767721831 cites W2073806182 @default.
• W2767721831 cites W2075864361 @default.
• W2767721831 cites W2079908656 @default.
• W2767721831 cites W2089858495 @default.
• W2767721831 cites W2096629218 @default.
• W2767721831 cites W2103789151 @default.
• W2767721831 cites W2105033552 @default.
• W2767721831 cites W2105920916 @default.
• W2767721831 cites W2116340390 @default.
• W2767721831 cites W2117600795 @default.
• W2767721831 cites W2117726420 @default.
• W2767721831 cites W2118825945 @default.
• W2767721831 cites W2120310131 @default.
• W2767721831 cites W2120481681 @default.
• W2767721831 cites W2126693856 @default.
• W2767721831 cites W2128784178 @default.
• W2767721831 cites W2131045394 @default.
• W2767721831 cites W2137774183 @default.
• W2767721831 cites W2138790588 @default.
• W2767721831 cites W2141640976 @default.
• W2767721831 cites W2143095378 @default.
• W2767721831 cites W2143308172 @default.
• W2767721831 cites W2144683341 @default.
• W2767721831 cites W2158396789 @default.
• W2767721831 cites W2160695817 @default.
• W2767721831 cites W2160779028 @default.
• W2767721831 cites W2162801180 @default.
• W2767721831 cites W2169155487 @default.
• W2767721831 cites W2263610200 @default.
• W2767721831 cites W2288200935 @default.
• W2767721831 cites W2332549914 @default.
• W2767721831 cites W2338785485 @default.
• W2767721831 cites W2432457035 @default.
• W2767721831 cites W2500084542 @default.
• W2767721831 cites W2518664057 @default.
• W2767721831 cites W4248772954 @default.
• W2767721831 doi "https://doi.org/10.1038/s41386-018-0056-2" @default.
• W2767721831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6006166" @default.
• W2767721831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29748629" @default.
• W2767721831 hasPublicationYear "2018" @default.
• W2767721831 type Work @default.
• W2767721831 sameAs 2767721831 @default.
• W2767721831 citedByCount "55" @default.
• W2767721831 countsByYear W27677218312017 @default.
• W2767721831 countsByYear W27677218312018 @default.
• W2767721831 countsByYear W27677218312019 @default.
• W2767721831 countsByYear W27677218312020 @default.
• W2767721831 countsByYear W27677218312021 @default.
• W2767721831 countsByYear W27677218312022 @default.
• W2767721831 countsByYear W27677218312023 @default.
• W2767721831 crossrefType "journal-article" @default.
• W2767721831 hasAuthorship W2767721831A5012357143 @default.
• W2767721831 hasAuthorship W2767721831A5015205461 @default.
• W2767721831 hasAuthorship W2767721831A5020886846 @default.
• W2767721831 hasAuthorship W2767721831A5041538919 @default.
• W2767721831 hasAuthorship W2767721831A5043075118 @default.
• W2767721831 hasAuthorship W2767721831A5044059700 @default.
• W2767721831 hasAuthorship W2767721831A5058623167 @default.
• W2767721831 hasAuthorship W2767721831A5072392137 @default.
• W2767721831 hasBestOaLocation W27677218311 @default.
• W2767721831 hasConcept C118552586 @default.
• W2767721831 hasConcept C137183658 @default.
• W2767721831 hasConcept C15744967 @default.

• next