Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767741561> ?p ?o ?g. }
- W2767741561 endingPage "244" @default.
- W2767741561 startingPage "226" @default.
- W2767741561 abstract "Patients recovering from sepsis have higher rates of CNS morbidities associated with long-lasting impairment of cognitive functions, including neurodegenerative diseases. However, the molecular etiology of these sepsis-induced impairments is unclear. Here, we investigated the role of the receptor for advanced glycation end products (RAGE) in neuroinflammation, neurodegeneration-associated changes, and cognitive dysfunction arising after sepsis recovery. Adult Wistar rats underwent cecal ligation and perforation (CLP), and serum and brain (hippocampus and prefrontal cortex) samples were obtained at days 1, 15, and 30 after the CLP. We examined these samples for systemic and brain inflammation; amyloid-β peptide (Aβ) and Ser-202–phosphorylated Tau (p-TauSer-202) levels; and RAGE, RAGE ligands, and RAGE intracellular signaling. Serum markers associated with the acute proinflammatory phase of sepsis (TNFα, IL-1β, and IL-6) rapidly increased and then progressively decreased during the 30-day period post-CLP, concomitant with a progressive increase in RAGE ligands (S100B, Nɛ-[carboxymethyl]lysine, HSP70, and HMGB1). In the brain, levels of RAGE and Toll-like receptor 4, glial fibrillary acidic protein and neuronal nitric-oxide synthase, and Aβ and p-TauSer-202 also increased during that time. Of note, intracerebral injection of RAGE antibody into the hippocampus at days 15, 17, and 19 post-CLP reduced Aβ and p-TauSer-202 accumulation, Akt/mechanistic target of rapamycin signaling, levels of ionized calcium-binding adapter molecule 1 and glial fibrillary acidic protein, and behavioral deficits associated with cognitive decline. These results indicate that brain RAGE is an essential factor in the pathogenesis of neurological disorders following acute systemic inflammation." @default.
- W2767741561 created "2017-11-17" @default.
- W2767741561 creator A5005644235 @default.
- W2767741561 creator A5015047182 @default.
- W2767741561 creator A5015184702 @default.
- W2767741561 creator A5018877036 @default.
- W2767741561 creator A5023832410 @default.
- W2767741561 creator A5028297592 @default.
- W2767741561 creator A5034419483 @default.
- W2767741561 creator A5046846669 @default.
- W2767741561 creator A5054266497 @default.
- W2767741561 creator A5055369872 @default.
- W2767741561 creator A5056281232 @default.
- W2767741561 creator A5084364321 @default.
- W2767741561 creator A5089983151 @default.
- W2767741561 date "2018-01-01" @default.
- W2767741561 modified "2023-10-17" @default.
- W2767741561 title "Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment" @default.
- W2767741561 cites W1004153210 @default.
- W2767741561 cites W115939226 @default.
- W2767741561 cites W1490795681 @default.
- W2767741561 cites W1512719559 @default.
- W2767741561 cites W1743841615 @default.
- W2767741561 cites W1944215271 @default.
- W2767741561 cites W1965232330 @default.
- W2767741561 cites W1965291001 @default.
- W2767741561 cites W1970215809 @default.
- W2767741561 cites W1977180762 @default.
- W2767741561 cites W1977355606 @default.
- W2767741561 cites W1978987033 @default.
- W2767741561 cites W1983483076 @default.
- W2767741561 cites W1986067129 @default.
- W2767741561 cites W1989063324 @default.
- W2767741561 cites W1993118022 @default.
- W2767741561 cites W2003591201 @default.
- W2767741561 cites W2005628434 @default.
- W2767741561 cites W2011560428 @default.
- W2767741561 cites W2021123891 @default.
- W2767741561 cites W2021133027 @default.
- W2767741561 cites W2023819682 @default.
- W2767741561 cites W2024731831 @default.
- W2767741561 cites W2027183895 @default.
- W2767741561 cites W2034502915 @default.
- W2767741561 cites W2036179978 @default.
- W2767741561 cites W2042991023 @default.
- W2767741561 cites W2044333192 @default.
- W2767741561 cites W2045509178 @default.
- W2767741561 cites W2047549421 @default.
- W2767741561 cites W2048359313 @default.
- W2767741561 cites W2050644696 @default.
- W2767741561 cites W2051145954 @default.
- W2767741561 cites W2057672006 @default.
- W2767741561 cites W2061278247 @default.
- W2767741561 cites W2071466153 @default.
- W2767741561 cites W2073080516 @default.
- W2767741561 cites W2075632954 @default.
- W2767741561 cites W2076143217 @default.
- W2767741561 cites W2079815081 @default.
- W2767741561 cites W2079819154 @default.
- W2767741561 cites W2080053658 @default.
- W2767741561 cites W2081610661 @default.
- W2767741561 cites W2082445194 @default.
- W2767741561 cites W2085154880 @default.
- W2767741561 cites W2098572294 @default.
- W2767741561 cites W2102761280 @default.
- W2767741561 cites W2105799653 @default.
- W2767741561 cites W2115633980 @default.
- W2767741561 cites W2128779293 @default.
- W2767741561 cites W2129085204 @default.
- W2767741561 cites W2130072278 @default.
- W2767741561 cites W2133625553 @default.
- W2767741561 cites W2135965744 @default.
- W2767741561 cites W2147473688 @default.
- W2767741561 cites W2147758827 @default.
- W2767741561 cites W2149354716 @default.
- W2767741561 cites W2154575244 @default.
- W2767741561 cites W2156659176 @default.
- W2767741561 cites W2165206966 @default.
- W2767741561 cites W2165298830 @default.
- W2767741561 cites W2169980814 @default.
- W2767741561 cites W2173599989 @default.
- W2767741561 cites W2222193500 @default.
- W2767741561 cites W2226005455 @default.
- W2767741561 cites W2233607184 @default.
- W2767741561 cites W2280404143 @default.
- W2767741561 cites W2296364176 @default.
- W2767741561 cites W2296740057 @default.
- W2767741561 cites W2307324788 @default.
- W2767741561 cites W2309034916 @default.
- W2767741561 cites W2328000515 @default.
- W2767741561 cites W2415001185 @default.
- W2767741561 cites W2418455583 @default.
- W2767741561 cites W2488339761 @default.
- W2767741561 cites W285026020 @default.
- W2767741561 cites W4293247451 @default.
- W2767741561 doi "https://doi.org/10.1074/jbc.m117.786756" @default.
- W2767741561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5766916" @default.
- W2767741561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29127203" @default.