Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767754823> ?p ?o ?g. }
- W2767754823 abstract "We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate signaling pathways. In the present study, we identified CD146 as a potential novel target, negatively regulated by CD44. While the exact function of CD146 in breast cancer (BC) is not completely understood, substantial evidence from our work and others support the hypothesis that CD146 is a suppressor of breast tumor progression. Therefore, using molecular and pharmacological approaches both in vitro and in breast tissues of human samples, the present study validated CD146 as a novel target of CD44-signaling suppressed during BC progression. Our results revealed that CD44 activation could cause a substantial decrease of CD146 expression with an equally notable converse effect upon CD44-siRNA inhibition. More interestingly, activation of CD44 decreased cellular CD146 and increased soluble CD146 through CD44-dependent activation of MMP. Here, we provide a possible mechanism by which CD146 suppresses BC progression as a target of CD44-downstream signaling, regulating neovascularization and cancer cell motility." @default.
- W2767754823 created "2017-11-17" @default.
- W2767754823 creator A5010642130 @default.
- W2767754823 creator A5017169906 @default.
- W2767754823 creator A5036358352 @default.
- W2767754823 creator A5048835237 @default.
- W2767754823 creator A5072619156 @default.
- W2767754823 date "2017-11-09" @default.
- W2767754823 modified "2023-10-16" @default.
- W2767754823 title "CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion" @default.
- W2767754823 cites W1539789596 @default.
- W2767754823 cites W1562576501 @default.
- W2767754823 cites W1606919584 @default.
- W2767754823 cites W167594194 @default.
- W2767754823 cites W193658783 @default.
- W2767754823 cites W1964539791 @default.
- W2767754823 cites W1968631675 @default.
- W2767754823 cites W1971133147 @default.
- W2767754823 cites W1982651263 @default.
- W2767754823 cites W1986935616 @default.
- W2767754823 cites W1988087047 @default.
- W2767754823 cites W1999985707 @default.
- W2767754823 cites W2003298858 @default.
- W2767754823 cites W2003638511 @default.
- W2767754823 cites W2005252392 @default.
- W2767754823 cites W2019520753 @default.
- W2767754823 cites W2032440454 @default.
- W2767754823 cites W2034038746 @default.
- W2767754823 cites W2041130952 @default.
- W2767754823 cites W2054498037 @default.
- W2767754823 cites W2066372035 @default.
- W2767754823 cites W2069344563 @default.
- W2767754823 cites W2075108645 @default.
- W2767754823 cites W2080983211 @default.
- W2767754823 cites W2084564750 @default.
- W2767754823 cites W2088082970 @default.
- W2767754823 cites W2097572463 @default.
- W2767754823 cites W2103779343 @default.
- W2767754823 cites W2104420419 @default.
- W2767754823 cites W2114059045 @default.
- W2767754823 cites W2127651945 @default.
- W2767754823 cites W2127771672 @default.
- W2767754823 cites W2131625781 @default.
- W2767754823 cites W2136835993 @default.
- W2767754823 cites W2151881986 @default.
- W2767754823 cites W2152776641 @default.
- W2767754823 cites W2165836231 @default.
- W2767754823 cites W2171798917 @default.
- W2767754823 cites W2329591400 @default.
- W2767754823 cites W2396492417 @default.
- W2767754823 cites W45280529 @default.
- W2767754823 cites W64416022 @default.
- W2767754823 cites W2182244606 @default.
- W2767754823 doi "https://doi.org/10.1186/s12964-017-0200-3" @default.
- W2767754823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5679321" @default.
- W2767754823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29121955" @default.
- W2767754823 hasPublicationYear "2017" @default.
- W2767754823 type Work @default.
- W2767754823 sameAs 2767754823 @default.
- W2767754823 citedByCount "12" @default.
- W2767754823 countsByYear W27677548232019 @default.
- W2767754823 countsByYear W27677548232020 @default.
- W2767754823 countsByYear W27677548232021 @default.
- W2767754823 countsByYear W27677548232022 @default.
- W2767754823 countsByYear W27677548232023 @default.
- W2767754823 crossrefType "journal-article" @default.
- W2767754823 hasAuthorship W2767754823A5010642130 @default.
- W2767754823 hasAuthorship W2767754823A5017169906 @default.
- W2767754823 hasAuthorship W2767754823A5036358352 @default.
- W2767754823 hasAuthorship W2767754823A5048835237 @default.
- W2767754823 hasAuthorship W2767754823A5072619156 @default.
- W2767754823 hasBestOaLocation W27677548231 @default.
- W2767754823 hasConcept C10205521 @default.
- W2767754823 hasConcept C121608353 @default.
- W2767754823 hasConcept C1491633281 @default.
- W2767754823 hasConcept C190283241 @default.
- W2767754823 hasConcept C2775975398 @default.
- W2767754823 hasConcept C2779093498 @default.
- W2767754823 hasConcept C2779256057 @default.
- W2767754823 hasConcept C2780932548 @default.
- W2767754823 hasConcept C28328180 @default.
- W2767754823 hasConcept C502942594 @default.
- W2767754823 hasConcept C54355233 @default.
- W2767754823 hasConcept C55493867 @default.
- W2767754823 hasConcept C62478195 @default.
- W2767754823 hasConcept C86803240 @default.
- W2767754823 hasConcept C95444343 @default.
- W2767754823 hasConceptScore W2767754823C10205521 @default.
- W2767754823 hasConceptScore W2767754823C121608353 @default.
- W2767754823 hasConceptScore W2767754823C1491633281 @default.
- W2767754823 hasConceptScore W2767754823C190283241 @default.
- W2767754823 hasConceptScore W2767754823C2775975398 @default.
- W2767754823 hasConceptScore W2767754823C2779093498 @default.
- W2767754823 hasConceptScore W2767754823C2779256057 @default.
- W2767754823 hasConceptScore W2767754823C2780932548 @default.
- W2767754823 hasConceptScore W2767754823C28328180 @default.
- W2767754823 hasConceptScore W2767754823C502942594 @default.
- W2767754823 hasConceptScore W2767754823C54355233 @default.
- W2767754823 hasConceptScore W2767754823C55493867 @default.
- W2767754823 hasConceptScore W2767754823C62478195 @default.