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- W2767768179 abstract "Background The field of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has suffered from a lack of clinical trials to validate its expanding use. Objective To evaluate published and ongoing clinical trials seeking to better define role of CRS/HIPEC in the treatment of peritoneal surface malignancies. Methods Systematic review by PubMed search was performed using terms “Clinical trial,” “intraperitoneal chemotherapy,” and “HIPEC.” ClinicalTrials.gov and EudraCT registries were searched for active clinical trials. Eligibility included CRS/HIPEC trials investigating adult patient populations from published clinical reports and/or trials currently accruing or at completion. Results Thirteen published trials and 57 active clinical trials were included for review. Conclusions Published and ongoing U.S. and international clinical trials for CRS and HIPEC are defining important parameters that include improving patient selection, strategic sequences of treatment, cytoreductive strategies, chemotherapeutics, optimal hyperthermic temperature and timing, and toxicity profiles. Main barriers or limitations to trial development remain patient enrollment, trial design, and oncologic community collaboration. Overall progress is positive with increasing number of clinical trials throughout the world. Collaboration between surgeons and the wider oncologic community will be crucial to validate this important treatment strategy." @default.
- W2767768179 created "2017-11-17" @default.
- W2767768179 creator A5001833990 @default.
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- W2767768179 creator A5012948442 @default.
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- W2767768179 date "2017-11-09" @default.
- W2767768179 modified "2023-09-29" @default.
- W2767768179 title "Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions-A systematic review" @default.
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- W2767768179 doi "https://doi.org/10.1002/jso.24813" @default.
- W2767768179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6692902" @default.
- W2767768179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29120491" @default.
- W2767768179 hasPublicationYear "2017" @default.
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