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• W2767769087 abstract "// Qingxi Qu 1 , Weidong Bing 1 , Xiangbin Meng 1 , Jie Xi 1 , Xiao Bai 1 , Qing Liu 2 , Yaqiu Guo 3 , Xin Zhao 1 and Yanwen Bi 1 1 Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China 2 Department of Ultrasound, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250012, China 3 Department of Anesthesiology, Jinan Maternity and Child Health Care Hospital, Jinan, Shandong 250012, China Correspondence to: Yanwen Bi, email: yanwenbi11@126.com.cn Keywords: miRNAs, human saphenous vein, vein graft, endothelial cells, neointimal formation Received: June 30, 2017      Accepted: August 27, 2017      Published: November 03, 2017 ABSTRACT Poor long-term patency of vein grafts remains an obstacle in coronary artery bypass grafting (CABG) surgery using an autologous saphenous vein graft. Recent studies have revealed that miR-126-3p promotes vascular integrity and angiogenesis. We aimed to identify the role of miR-126-3p in the setting of vein graft disease and investigate the value of miR-126-3p agomir as a future gene therapy in vein graft failure. Expression analysis of circulating miR-126-3p in plasma from CABG patients established the basic clues that miR-126-3p participates in CABG. The in vitro results indicated that elevated miR-126-3p expression significantly improved proliferation and migration in human saphenous vein endothelial cells (HSVECs) by targeting sprouty-related protein-1 (SPRED-1) and phosphatidylinositol-3-kinase regulatory subunit 2 (PIK3R2), but not in human saphenous vein smooth muscle cells (HSVSMCs). Moreover, the therapeutic potential of miR-126-3p agomir was demonstrated in cultured human saphenous vein (HSV) ex vivo . Finally, local delivery of miR-126-3p agomir was confirmed to enhance reendothelialization and attenuate neointimal formation in a rat vein arterialization model. In conclusion, we provide evidence that upregulation of miR-126-3p by agomir possesses potential clinical value in the prevention and treatment of autologous vein graft restenosis in CABG." @default.
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• W2767769087 date "2017-11-03" @default.
• W2767769087 modified "2023-10-16" @default.
• W2767769087 title "Upregulation of miR-126-3p promotes human saphenous vein endothelial cell proliferation <i>in vitro</i> and prevents vein graft neointimal formation <i>ex vivo</i> and <i>in vivo</i>" @default.
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• W2767769087 doi "https://doi.org/10.18632/oncotarget.22365" @default.
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