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- W2767804576 abstract "Abstract Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized β-actin filament assembly at the site of cytokinesis. β-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of β-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions." @default.
- W2767804576 created "2017-11-17" @default.
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- W2767804576 date "2017-11-16" @default.
- W2767804576 modified "2023-10-13" @default.
- W2767804576 title "Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator" @default.
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- W2767804576 doi "https://doi.org/10.1038/s41467-017-01231-x" @default.
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