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- W2767804988 abstract "Background: Pediatric oncology patients are more likely to develop venous thromboembolic events CVC–related, but the incidence of CVC-related thrombosis (CRT) is still under debate. First objective of this perspective monocentric study is to investigate the incidence of symptomatic and asymptomatic CRT using Doppler Ultrasound and evaluate the possible risk factors linked to this pathology. Methods: This study was performed on all paediatric patients with cancer, aged< 18, requiring CVC implantation for chemotherapy infusion, from October 2015 to December 2016 in Istituto Nazionale Tumori of Milan. All patients underwent US examination at 15, 30 and 90 days after implantation. Results: A total of 114 medium - long term CVC were inserted into 104 patients (median age; range: 9.5; 0.4-17 years). Patients have been followed up for an average of 269 (range: 11-503) days. Incidence of asymptomatic CRT was 0.11 (0.03-0.33) events for 1000 catheter-days. Only three cases of thrombosis were identified with Doppler Ultrasound screening. In no patient symptomatic DVT occurred. The only common risk factor in these cases was the presence of a previous catheter-related infection (p value= 0.0018). Conclusion: Despite the high risk of CRT associated with the considered sample, the incidence of symptomatic and asymptomatic thrombosis in our patients is very low, especially when compared to other studies. Following these results, the role of US surveillance for the prevention of CRT could be revaluated, perhaps limiting it to patients with previous CVC-related complications. Possible limitations of this study are the limited number of patients and the limited follow up." @default.
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- W2767804988 date "2017-10-01" @default.
- W2767804988 modified "2023-09-27" @default.
- W2767804988 title "Occurrence of ultrasound-detected symptomatic and asymptomatic central vein catheter-related thrombosis in pediatric oncology patients" @default.
- W2767804988 doi "https://doi.org/10.1093/annonc/mdx433.004" @default.
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