Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767832013> ?p ?o ?g. }
- W2767832013 abstract "Oxidation of LDL is widely believed to be a key process in the pathogenesis of atherosclerosis. However, LDL oxidation has been shown to be inhibited by interstitial fluid and also large clinical trials have shown no protection by antioxidant. Recent work has shown that LDL can be oxidised by iron within the lysosomes of macrophages. Here, we have explored the possible mechanism by which iron is able to oxidise LDL under lysosomal conditions, and also how lysosomotropic antioxidant, cysteamine is able to prevent it. More recently, it has been shown that human macrophages are able to rapidly phagocytose LDL aggregated by enzymes, such as sphingomyelinase (SMaseLDL) and oxidised it by iron inside lysosomes, which have a pH of about 4.5. Here, the chemical characteristics (lipid hydroperoxides and oxysterols) of SMase-LDL oxidised by inorganic iron at lysosomal pH (4.5) have been determined in vitro andcompared to the native LDL. In the lysosomes of macrophages, SMase-LDL increased the intralysosomal lipid peroxidation and ceroid formation which was greatly inhibited by cysteamine. There is good evidence which suggests that lysosomal dysfunction plays an important role in the atherosclerotic plaque development. Here, it is shown that lysosomal oxidation of SMase-LDL in human macrophages can cause lysosomal dysfunction, induce ceroid associated cellular senescence, and increase theexpression of inflammatory cytokine like TNF-α. The work here also demonstrates that preventing the lysosomal LDL oxidation, with antioxidants like cysteamine, offers protection against the SMase-LDL induced lysosomal dysfunction" @default.
- W2767832013 created "2017-11-17" @default.
- W2767832013 creator A5049153836 @default.
- W2767832013 date "2017-01-01" @default.
- W2767832013 modified "2023-09-23" @default.
- W2767832013 title "Lysosomal oxidation of Low Density Lipoproteins" @default.
- W2767832013 cites W112986408 @default.
- W2767832013 cites W11304378 @default.
- W2767832013 cites W1205458192 @default.
- W2767832013 cites W14380143 @default.
- W2767832013 cites W1485806819 @default.
- W2767832013 cites W1485928230 @default.
- W2767832013 cites W1486525201 @default.
- W2767832013 cites W1509255658 @default.
- W2767832013 cites W1513225799 @default.
- W2767832013 cites W1528170782 @default.
- W2767832013 cites W153121858 @default.
- W2767832013 cites W1538904872 @default.
- W2767832013 cites W1541426877 @default.
- W2767832013 cites W1543341135 @default.
- W2767832013 cites W1543931506 @default.
- W2767832013 cites W1544932752 @default.
- W2767832013 cites W1547916425 @default.
- W2767832013 cites W1556483054 @default.
- W2767832013 cites W1558415539 @default.
- W2767832013 cites W1559813904 @default.
- W2767832013 cites W1562912987 @default.
- W2767832013 cites W1564614698 @default.
- W2767832013 cites W1585231690 @default.
- W2767832013 cites W1586936525 @default.
- W2767832013 cites W1590005134 @default.
- W2767832013 cites W1597938677 @default.
- W2767832013 cites W1602214891 @default.
- W2767832013 cites W161111778 @default.
- W2767832013 cites W1626021976 @default.
- W2767832013 cites W1659141691 @default.
- W2767832013 cites W1707178069 @default.
- W2767832013 cites W1779788530 @default.
- W2767832013 cites W1832809476 @default.
- W2767832013 cites W1837885370 @default.
- W2767832013 cites W1841006369 @default.
- W2767832013 cites W1853133898 @default.
- W2767832013 cites W1857052429 @default.
- W2767832013 cites W1858726987 @default.
- W2767832013 cites W1873572294 @default.
- W2767832013 cites W1885709517 @default.
- W2767832013 cites W1889443575 @default.
- W2767832013 cites W1898188068 @default.
- W2767832013 cites W1900339045 @default.
- W2767832013 cites W1934393343 @default.
- W2767832013 cites W1935632736 @default.
- W2767832013 cites W1946641020 @default.
- W2767832013 cites W1958100988 @default.
- W2767832013 cites W1963749512 @default.
- W2767832013 cites W1964543952 @default.
- W2767832013 cites W1964909603 @default.
- W2767832013 cites W1965006614 @default.
- W2767832013 cites W1965079716 @default.
- W2767832013 cites W1966027404 @default.
- W2767832013 cites W1967253109 @default.
- W2767832013 cites W1968171440 @default.
- W2767832013 cites W1968330432 @default.
- W2767832013 cites W1968559867 @default.
- W2767832013 cites W1968679020 @default.
- W2767832013 cites W1968752758 @default.
- W2767832013 cites W1969374802 @default.
- W2767832013 cites W1969827113 @default.
- W2767832013 cites W1970185441 @default.
- W2767832013 cites W1970719858 @default.
- W2767832013 cites W1971123289 @default.
- W2767832013 cites W1971240175 @default.
- W2767832013 cites W1971391254 @default.
- W2767832013 cites W1971530727 @default.
- W2767832013 cites W1971904508 @default.
- W2767832013 cites W1972409849 @default.
- W2767832013 cites W1972566357 @default.
- W2767832013 cites W1972784644 @default.
- W2767832013 cites W1973865405 @default.
- W2767832013 cites W1974943429 @default.
- W2767832013 cites W1975036384 @default.
- W2767832013 cites W1975365507 @default.
- W2767832013 cites W1976382352 @default.
- W2767832013 cites W1976567109 @default.
- W2767832013 cites W1976616659 @default.
- W2767832013 cites W1977317764 @default.
- W2767832013 cites W1977622544 @default.
- W2767832013 cites W1978470067 @default.
- W2767832013 cites W1978488208 @default.
- W2767832013 cites W1978598997 @default.
- W2767832013 cites W1978847420 @default.
- W2767832013 cites W1978854613 @default.
- W2767832013 cites W1978992492 @default.
- W2767832013 cites W1979230087 @default.
- W2767832013 cites W1979309869 @default.
- W2767832013 cites W1982126567 @default.
- W2767832013 cites W1982638309 @default.
- W2767832013 cites W1982900915 @default.
- W2767832013 cites W1985294414 @default.
- W2767832013 cites W1986775771 @default.
- W2767832013 cites W1987627047 @default.