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- W2767834783 abstract "Heat stress negatively affects cow performance, compromises immune function, and increases susceptibility to metabolic disorders, particularly during the dry period and as cows transition from gestation to lactation. Metabolic adaptations of the liver are critical for successful transition, yet it is unclear how heat stress affects metabolic pathways within the liver at the proteomic level. The objective of this study was to investigate the liver proteome of postpartum cows that were cooled or heat stressed during the dry period to gain insight into how protein expression is altered by prior heat stress and may contribute to performance and disease outcomes. During the dry period, cows were either housed in shaded barns with fans and water soakers [cooled group (CL); n = 5] or in shaded barns lacking these cooling devices [heat-stressed group (HT); n = 5]. Liver biopsies were collected at 2 d postpartum, and protein content was analyzed by label-free quantitative shotgun proteomics (nanoscale liquid chromatography coupled to tandem mass spectrometry). In the most comprehensive bovine liver proteomics analysis completed to date, we identified 3,270 proteins, 75 of which were differentially expressed between HT and CL cows (fold change ±1.2). The top pathways differing between HT and CL cows were oxidative phosphorylation, mitochondrial dysfunction, farnesoid X receptor/retinoid X receptor (FXR/RXR) activation, and the methylmalonyl pathway. Cooling cows during the dry period likely improves ATP production, reduces oxidative stress, and prevents excessive accumulation of hepatic triglycerides and cholesterol, which may contribute to greater milk yield and lower susceptibility to transition-related diseases." @default.
- W2767834783 created "2017-11-17" @default.
- W2767834783 creator A5013496664 @default.
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- W2767834783 date "2018-01-01" @default.
- W2767834783 modified "2023-10-12" @default.
- W2767834783 title "Liver proteomic analysis of postpartum Holstein cows exposed to heat stress or cooling conditions during the dry period" @default.
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- W2767834783 doi "https://doi.org/10.3168/jds.2017-13258" @default.
- W2767834783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29128212" @default.
- W2767834783 hasPublicationYear "2018" @default.
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