FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767862009> ?p ?o ?g. }

• W2767862009 endingPage "1937" @default.
• W2767862009 startingPage "1937" @default.
• W2767862009 abstract "SimiaoYong’an Decoction (SYD) is a classical traditional Chinese prescription that is used for the treatment of gangrene, heat-clearing, detoxification and pain alleviation. We developed a sensitive ultra-performance liquid chromatography-tandem mass spectrum (UPLC-MS/MS) method for the simultaneous determination of seven major active ingredients of SYD extract (i.e., harpagide, chlorogenic acid, sweroside, loganin, liquiritin, angoroside C and harpagoside) in rat plasma. The preliminary steps in the plasma analysis were the addition of an internal standard such as linarin, followed by protein precipitation with methanol. Separation of the active ingredients was performed on an ACQUITY UPLC® BEH C18 column (100 mm × 2.1 mm, 1.7 μm) at a flow rate of 0.2 mL/min with methanol/water 0.1% formic acid aqueous (V/V) as the mobile phase. Detection was performed on a triple quadrupole tandem MS (QqQ-MS) via negative ion electrospray ionization in multiple reactions monitoring (MRM) mode. All calibration curves showed good linearity (r > 0.99) over the concentration range with a low limit of quantification between 0.029 and 5.813 ng/mL. Precision was evaluated by intra-day and inter-day assays, and the percentages of the RSD were all within 8.1%. The extraction efficiency and matrix effect were 80.6–113.6% and 82.9–99.5%, respectively. The validated method was successfully applied to a pharmacokinetic study in rats after oral administration of SYD extract and the corresponding single and combined traditional Chinese medicines (TCMs). The pharmacokinetic properties of the seven ingredients showed dynamic changes due to counteraction among the different coexisting components. The established approach has proven useful in the study of the active constituents in a traditional Chinese prescription." @default.
• W2767862009 created "2017-11-17" @default.
• W2767862009 creator A5013950799 @default.
• W2767862009 creator A5016748917 @default.
• W2767862009 creator A5070908864 @default.
• W2767862009 creator A5088956207 @default.
• W2767862009 creator A5091145763 @default.
• W2767862009 date "2017-11-09" @default.
• W2767862009 modified "2023-09-26" @default.
• W2767862009 title "Simultaneous Determination of Seven Components in Rat Plasma by the UPLC-MS/MS Method and Application of Pharmacokinetic Studies to SimiaoYong’an Decoction" @default.
• W2767862009 cites W1599817252 @default.
• W2767862009 cites W1971154691 @default.
• W2767862009 cites W1983427728 @default.
• W2767862009 cites W1997458238 @default.
• W2767862009 cites W2010427019 @default.
• W2767862009 cites W2016029365 @default.
• W2767862009 cites W2018428467 @default.
• W2767862009 cites W2021228533 @default.
• W2767862009 cites W2027706710 @default.
• W2767862009 cites W2042326514 @default.
• W2767862009 cites W2044079169 @default.
• W2767862009 cites W2049277503 @default.
• W2767862009 cites W2054854788 @default.
• W2767862009 cites W2059960883 @default.
• W2767862009 cites W2088103680 @default.
• W2767862009 cites W2117260769 @default.
• W2767862009 cites W2214503903 @default.
• W2767862009 cites W2266158201 @default.
• W2767862009 cites W2362942184 @default.
• W2767862009 cites W2427346690 @default.
• W2767862009 cites W2443864270 @default.
• W2767862009 cites W2507253898 @default.
• W2767862009 cites W257714394 @default.
• W2767862009 cites W2605131570 @default.
• W2767862009 cites W2728213739 @default.
• W2767862009 cites W2736350616 @default.
• W2767862009 cites W2756765799 @default.
• W2767862009 cites W2757062831 @default.
• W2767862009 cites W3143618686 @default.
• W2767862009 cites W372574929 @default.
• W2767862009 doi "https://doi.org/10.3390/molecules22111937" @default.
• W2767862009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6150365" @default.
• W2767862009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29120359" @default.
• W2767862009 hasPublicationYear "2017" @default.
• W2767862009 type Work @default.
• W2767862009 sameAs 2767862009 @default.
• W2767862009 citedByCount "11" @default.
• W2767862009 countsByYear W27678620092018 @default.
• W2767862009 countsByYear W27678620092019 @default.
• W2767862009 countsByYear W27678620092020 @default.
• W2767862009 countsByYear W27678620092022 @default.
• W2767862009 countsByYear W27678620092023 @default.
• W2767862009 crossrefType "journal-article" @default.
• W2767862009 hasAuthorship W2767862009A5013950799 @default.
• W2767862009 hasAuthorship W2767862009A5016748917 @default.
• W2767862009 hasAuthorship W2767862009A5070908864 @default.
• W2767862009 hasAuthorship W2767862009A5088956207 @default.
• W2767862009 hasAuthorship W2767862009A5091145763 @default.
• W2767862009 hasBestOaLocation W27678620091 @default.
• W2767862009 hasConcept C112705442 @default.
• W2767862009 hasConcept C162356407 @default.
• W2767862009 hasConcept C179998833 @default.
• W2767862009 hasConcept C185592680 @default.
• W2767862009 hasConcept C190409667 @default.
• W2767862009 hasConcept C2776918747 @default.
• W2767862009 hasConcept C2777379063 @default.
• W2767862009 hasConcept C2779091547 @default.
• W2767862009 hasConcept C2780117898 @default.
• W2767862009 hasConcept C2780536827 @default.
• W2767862009 hasConcept C31827203 @default.
• W2767862009 hasConcept C40684141 @default.
• W2767862009 hasConcept C43617362 @default.
• W2767862009 hasConcept C556039675 @default.
• W2767862009 hasConcept C59822182 @default.
• W2767862009 hasConcept C71043704 @default.
• W2767862009 hasConcept C71924100 @default.
• W2767862009 hasConcept C74774607 @default.
• W2767862009 hasConcept C86803240 @default.
• W2767862009 hasConcept C98274493 @default.
• W2767862009 hasConceptScore W2767862009C112705442 @default.
• W2767862009 hasConceptScore W2767862009C162356407 @default.
• W2767862009 hasConceptScore W2767862009C179998833 @default.
• W2767862009 hasConceptScore W2767862009C185592680 @default.
• W2767862009 hasConceptScore W2767862009C190409667 @default.
• W2767862009 hasConceptScore W2767862009C2776918747 @default.
• W2767862009 hasConceptScore W2767862009C2777379063 @default.
• W2767862009 hasConceptScore W2767862009C2779091547 @default.
• W2767862009 hasConceptScore W2767862009C2780117898 @default.
• W2767862009 hasConceptScore W2767862009C2780536827 @default.
• W2767862009 hasConceptScore W2767862009C31827203 @default.
• W2767862009 hasConceptScore W2767862009C40684141 @default.
• W2767862009 hasConceptScore W2767862009C43617362 @default.
• W2767862009 hasConceptScore W2767862009C556039675 @default.
• W2767862009 hasConceptScore W2767862009C59822182 @default.
• W2767862009 hasConceptScore W2767862009C71043704 @default.
• W2767862009 hasConceptScore W2767862009C71924100 @default.
• W2767862009 hasConceptScore W2767862009C74774607 @default.
• W2767862009 hasConceptScore W2767862009C86803240 @default.

• next