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- W2767862263 abstract "We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidepressant effects on restraint stress-induced depression in both wildtype and GluN2D-KO mice. The antidepressant effects of (RS)-ketamine and (S)-ketamine were sustained 96 h after the injection in both wildtype and GluN2D-KO mice, but such sustained antidepressant effects of (R)-ketamine were only observed in wildtype mice. These data suggest that the GluN2D subunit is critical for the sustained antidepressant effects of (R)-ketamine." @default.
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- W2767862263 date "2017-11-01" @default.
- W2767862263 modified "2023-10-16" @default.
- W2767862263 title "Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine" @default.
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- W2767862263 doi "https://doi.org/10.1016/j.jphs.2017.11.001" @default.
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