FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767874302> ?p ?o ?g. }

• W2767874302 endingPage "82" @default.
• W2767874302 startingPage "71" @default.
• W2767874302 abstract "Cyclophosphamide (CP) is widely used in anticancer therapy regimens and 2-dechloroethylcyclophosphamide (DECP) is its side-chain dechloroethylated metabolite. N-dechloroethylation of CP mediated by the enzyme CYP3A4 yields nephrotoxic and neurotoxic chloroacetaldehyde (CAA) in equimolar amount to DECP. This study aimed to evaluate the inhibitory effect of ketoconazole (KTZ) on CP metabolism through in vitro and in vivo drug-drug interaction (DDI) research. Long-term treatment of KTZ induces hepatic injury; thus single doses of KTZ at low, middle, and high levels (10, 20, and 40 mg/kg) were investigated for pharmacokinetic DDI with CP. Our in vitro human liver microsome modeling approach suggested that KTZ inhibited CYP3A4 activity and then decreased DECP exposure. In addition, an UHPLC-MS/MS method for quantifying CP, DECP, and KTZ in rat plasma was developed and fully validated with a 4 min analysis coupled with a simple and reproducible one-step protein precipitation. A further in vivo pharmacokinetic study demonstrated that combination use of CP (10 mg/kg) and KTZ (10, 20, and 40 mg/kg) in rats caused a KTZ dose-dependent decrease in main parameters of DECP (Cmax, Tmax, and AUC0–∞) and provided magnitude exposure of DECP (more than a 50% AUC decrease) as a consequence of CYP3A inhibition but had only a small effect on the CP plasma concentration. Our results suggested that combination usage of a CYP3A4 inhibitor like KTZ may decrease CAA exposure and thus intervene against CAA-induced adverse effects in CP clinical treatment." @default.
• W2767874302 created "2017-11-17" @default.
• W2767874302 creator A5016717316 @default.
• W2767874302 creator A5030976052 @default.
• W2767874302 creator A5033846884 @default.
• W2767874302 creator A5034237161 @default.
• W2767874302 creator A5039054300 @default.
• W2767874302 creator A5045557806 @default.
• W2767874302 creator A5052274720 @default.
• W2767874302 creator A5087663224 @default.
• W2767874302 date "2018-01-01" @default.
• W2767874302 modified "2023-10-16" @default.
• W2767874302 title "Effects of ketoconazole on cyclophosphamide metabolism: evaluation of CYP3A4 inhibition effect using the <i>in vitro</i> and <i>in vivo</i> models" @default.
• W2767874302 cites W1834073155 @default.
• W2767874302 cites W1969454129 @default.
• W2767874302 cites W1969745666 @default.
• W2767874302 cites W1971003608 @default.
• W2767874302 cites W1973239695 @default.
• W2767874302 cites W1976325405 @default.
• W2767874302 cites W1978902097 @default.
• W2767874302 cites W1982158532 @default.
• W2767874302 cites W2006319640 @default.
• W2767874302 cites W2008550629 @default.
• W2767874302 cites W2017743513 @default.
• W2767874302 cites W2024801247 @default.
• W2767874302 cites W2041101987 @default.
• W2767874302 cites W2041293152 @default.
• W2767874302 cites W2043091799 @default.
• W2767874302 cites W2048285147 @default.
• W2767874302 cites W2052396939 @default.
• W2767874302 cites W2060914851 @default.
• W2767874302 cites W2062764969 @default.
• W2767874302 cites W2072452271 @default.
• W2767874302 cites W2074373747 @default.
• W2767874302 cites W2082909557 @default.
• W2767874302 cites W2085919951 @default.
• W2767874302 cites W2090347109 @default.
• W2767874302 cites W2091145632 @default.
• W2767874302 cites W2092975507 @default.
• W2767874302 cites W2107643897 @default.
• W2767874302 cites W2112949206 @default.
• W2767874302 cites W2128635872 @default.
• W2767874302 cites W2132172164 @default.
• W2767874302 cites W2136791626 @default.
• W2767874302 cites W2154736427 @default.
• W2767874302 cites W2157010919 @default.
• W2767874302 cites W2165269090 @default.
• W2767874302 cites W2165695983 @default.
• W2767874302 cites W2174360049 @default.
• W2767874302 cites W2180101796 @default.
• W2767874302 cites W2507785397 @default.
• W2767874302 cites W2549463667 @default.
• W2767874302 cites W2592918362 @default.
• W2767874302 cites W3149641479 @default.
• W2767874302 cites W4248508174 @default.
• W2767874302 cites W4293247451 @default.
• W2767874302 doi "https://doi.org/10.1538/expanim.17-0048" @default.
• W2767874302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5814316" @default.
• W2767874302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29129847" @default.
• W2767874302 hasPublicationYear "2018" @default.
• W2767874302 type Work @default.
• W2767874302 sameAs 2767874302 @default.
• W2767874302 citedByCount "21" @default.
• W2767874302 countsByYear W27678743022018 @default.
• W2767874302 countsByYear W27678743022019 @default.
• W2767874302 countsByYear W27678743022020 @default.
• W2767874302 countsByYear W27678743022021 @default.
• W2767874302 countsByYear W27678743022022 @default.
• W2767874302 countsByYear W27678743022023 @default.
• W2767874302 crossrefType "journal-article" @default.
• W2767874302 hasAuthorship W2767874302A5016717316 @default.
• W2767874302 hasAuthorship W2767874302A5030976052 @default.
• W2767874302 hasAuthorship W2767874302A5033846884 @default.
• W2767874302 hasAuthorship W2767874302A5034237161 @default.
• W2767874302 hasAuthorship W2767874302A5039054300 @default.
• W2767874302 hasAuthorship W2767874302A5045557806 @default.
• W2767874302 hasAuthorship W2767874302A5052274720 @default.
• W2767874302 hasAuthorship W2767874302A5087663224 @default.
• W2767874302 hasBestOaLocation W27678743021 @default.
• W2767874302 hasConcept C109650736 @default.
• W2767874302 hasConcept C112705442 @default.
• W2767874302 hasConcept C11824378 @default.
• W2767874302 hasConcept C149151106 @default.
• W2767874302 hasConcept C150903083 @default.
• W2767874302 hasConcept C16005928 @default.
• W2767874302 hasConcept C185592680 @default.
• W2767874302 hasConcept C202751555 @default.
• W2767874302 hasConcept C207001950 @default.
• W2767874302 hasConcept C22979827 @default.
• W2767874302 hasConcept C2777477808 @default.
• W2767874302 hasConcept C2779548794 @default.
• W2767874302 hasConcept C2781064554 @default.
• W2767874302 hasConcept C526171541 @default.
• W2767874302 hasConcept C55493867 @default.
• W2767874302 hasConcept C62231903 @default.
• W2767874302 hasConcept C71924100 @default.
• W2767874302 hasConcept C86803240 @default.
• W2767874302 hasConcept C87644729 @default.

• next