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- W2767903992 abstract "The diagnosis and treatment of lung adenocarcinoma has been revolutionized by the discovery of oncogenic driver alterations and the parallel development and testing of genetically targeted agents, leading to the era of “precision medicine” in solid tumor oncology. Understanding and interpreting the molecular pathology of lung adenocarcinoma is now key in the stratification of patients for appropriate initial targeted therapy and downstream resistance profiling. Multiple complementary methods to assess the molecular phenotype of lung adenocarcinoma exist, including gene sequencing, FISH, and immunohistochemistry. Next-generation sequencing now allows for quantitative multiparametric genetic profiling (single nucleotide, copy number, and structural variants) of lung adenocarcinoma at diagnosis and during tumor evolution and will likely become the molecular assay of choice for less biased profiling of lung adenocarcinoma. Resulting molecular pathology data must be carefully integrated into the plan of care by a multidisciplinary team comprised of surgeons, oncologists, and pathologists, to ensure accurate diagnosis and appropriate treatment of lung adenocarcinoma." @default.
- W2767903992 created "2017-11-17" @default.
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- W2767903992 date "2017-08-14" @default.
- W2767903992 modified "2023-09-27" @default.
- W2767903992 title "Mutations as Predictive Biomarkers for Adenocarcinoma" @default.
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- W2767903992 doi "https://doi.org/10.1007/978-3-319-62941-4_11" @default.
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