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- W2767915360 abstract "Significance Immunosuppression by regulatory T cells (Tregs) is essential for the maintenance of self-tolerance, but it is detrimental in cancer because Tregs inhibit antitumor immunity. Development of therapeutic tools to block Tregs in patients with cancer requires a precise understanding of how human Tregs suppress immune responses. We recently identified an important mechanism implicating release of the active form of TGF-β1, a potently immunosuppressive cytokine, from GARP/latent TGF-β1 complexes on the surface of human Tregs. Here we unravel the molecular process leading to this release. We identify integrin αVβ8 as indispensable for TGF-β1 activation from GARP/latent TGF-β1 complexes. We show that anti-β8 monoclonals block immunosuppression by human Tregs in vivo and could thus serve in cancer immunotherapy." @default.
- W2767915360 created "2017-11-17" @default.
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- W2767915360 date "2017-11-06" @default.
- W2767915360 modified "2023-10-10" @default.
- W2767915360 title "Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8" @default.
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- W2767915360 doi "https://doi.org/10.1073/pnas.1710680114" @default.
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