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• W2767922845 abstract "// Yong Yang 1, * , Baoyang Luo 1, * , Yong An 1 , Han Sun 2 , Huihua Cai 1 and Donglin Sun 1 1 Department of Hepatobiliary Pancreatic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China 2 Department of Orthopedic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China * These authors contributed equally to this work Correspondence to: Donglin Sun, email: czsdl@sina.com Keywords: CXCR2, survival, solid tumor, biomarker, meta-analysis Received: July 03, 2017      Accepted: October 02, 2017      Published: November 03, 2017 ABSTRACT CXC chemokine receptor-2 (CXCR2) expression is associated with the prognosis of multiple cancers. We performed a meta-analysis to determine the association between the CXCR2 expression in tumor tissue and patient prognosis. We compiled related literature from PubMed, Embase, and Web of Science (last updated July 31, 2017). A total of 4012 patients with solid tumors from 21 studies were included to evaluate the association between CXCR2 and overall survival, recurrence-free survival, or disease-free survival. High CXCR2 expression was significantly associated with poor overall survival (pooled HR = 1.82; 95% CI = 1.63–2.03; P < 0.001), recurrence-free survival (pooled HR = 1.40; 95% CI = 1.21–1.62; P < 0.001), and disease-free survival (pooled HR = 1.89; 95% CI = 1.05–3.40; P = 0.033), especially in patients with digestive system neoplasms. Thus high CXCR2 expression in tumor tissue appears predictive of a poor prognosis in patients with solid tumors. Further studies will be required to determine whether CXCR2 blockade has a favorable effect on the prognosis of patients with cancer." @default.
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• W2767922845 date "2017-11-03" @default.
• W2767922845 modified "2023-09-26" @default.
• W2767922845 title "Systematic review and meta-analysis of the prognostic value of CXCR2 in solid tumor patients" @default.
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• W2767922845 doi "https://doi.org/10.18632/oncotarget.22285" @default.
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