FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767925261> ?p ?o ?g. }

• W2767925261 abstract "High-mobility group AT-hook 2 (HMGA2), a member of the high mobility group family, has been reported to correlate with cancer progression. However, there is no report concerning the correlation between HMGA2 and metastasis in renal cell carcinoma. In the present study, we found that HMGA2 was highly expressed in five renal cell carcinoma cell lines compared with that in the normal renal tubular epithelial HK2 cell line. Additionally, HMGA2 facilitated cell migration and invasion of renal cell carcinoma cells, as evidenced by wound healing and Transwell assays. Subsequently, our results revealed that the E‑cadherin level was upregulated, while N‑cadherin, Twist1 and Twist2 expression were downregulated in HMGA2-depleted ACHN cells. In contrast, overexpression of HMGA2 in 786‑O cells enhanced epithelial-mesenchymal transition (EMT). In addition, analysis of the database Cancer Browser further validated the positive correlation between HGMA2 and Twist1 or Twist2 in renal cell carcinoma. Meanwhile, Kaplan-Meier analysis indicated that low HMGA2 expression was closely associated with an increased overall survival in renal cell carcinoma patients. To confirm the underlying mechanism of HMGA2-regulated EMT, our results revealed that silencing of HMGA2 downregulated the mRNA and protein levels of TGF-β and Smad2, while HMGA2 overexpression had the opposite effect. Furthermore, TGF-β overexpression could partially reverse the anti-metastatic effect and mesenchymal-epithelial transition (MET) by HMGA2 loss, while TGF-β deficiency impeded the pro‑metastatic phenotype and high expression of EMT markers induced by HMGA2 overexpression. In summary, our results demonstrated that HMGA2 facilitated a metastatic phenotype and the EMT process in renal cell carcinoma cells in vitro through a TGF-β-dependent pathway. In addition, these data strongly suggest that HGMA2 may serve as a potential therapeutic target and prognostic biomarker against renal cell carcinoma in the future." @default.
• W2767925261 created "2017-11-17" @default.
• W2767925261 creator A5020255669 @default.
• W2767925261 creator A5058401189 @default.
• W2767925261 creator A5060960849 @default.
• W2767925261 creator A5071037763 @default.
• W2767925261 date "2017-11-10" @default.
• W2767925261 modified "2023-10-18" @default.
• W2767925261 title "HMGA2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating the TGF-β/Smad2 signaling pathway" @default.
• W2767925261 cites W1495624224 @default.
• W2767925261 cites W1922961650 @default.
• W2767925261 cites W1999918093 @default.
• W2767925261 cites W2016580535 @default.
• W2767925261 cites W2039620381 @default.
• W2767925261 cites W2051511388 @default.
• W2767925261 cites W2056846536 @default.
• W2767925261 cites W2060510577 @default.
• W2767925261 cites W2062365157 @default.
• W2767925261 cites W2072177644 @default.
• W2767925261 cites W2077746179 @default.
• W2767925261 cites W2086250036 @default.
• W2767925261 cites W2091885208 @default.
• W2767925261 cites W2113405864 @default.
• W2767925261 cites W2148606273 @default.
• W2767925261 cites W2172255896 @default.
• W2767925261 cites W2176667622 @default.
• W2767925261 cites W2224938023 @default.
• W2767925261 cites W2261520634 @default.
• W2767925261 cites W2325891005 @default.
• W2767925261 cites W2337367857 @default.
• W2767925261 cites W2520686520 @default.
• W2767925261 cites W2541686656 @default.
• W2767925261 cites W2553493312 @default.
• W2767925261 cites W2580740170 @default.
• W2767925261 cites W2584908080 @default.
• W2767925261 cites W2605909693 @default.
• W2767925261 cites W2610287357 @default.
• W2767925261 cites W2611534151 @default.
• W2767925261 cites W2611929337 @default.
• W2767925261 cites W2613848594 @default.
• W2767925261 cites W2618403463 @default.
• W2767925261 cites W767967839 @default.
• W2767925261 doi "https://doi.org/10.3892/or.2017.6091" @default.
• W2767925261 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5783590" @default.
• W2767925261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29138866" @default.
• W2767925261 hasPublicationYear "2017" @default.
• W2767925261 type Work @default.
• W2767925261 sameAs 2767925261 @default.
• W2767925261 citedByCount "17" @default.
• W2767925261 countsByYear W27679252612018 @default.
• W2767925261 countsByYear W27679252612019 @default.
• W2767925261 countsByYear W27679252612020 @default.
• W2767925261 countsByYear W27679252612021 @default.
• W2767925261 countsByYear W27679252612022 @default.
• W2767925261 countsByYear W27679252612023 @default.
• W2767925261 crossrefType "journal-article" @default.
• W2767925261 hasAuthorship W2767925261A5020255669 @default.
• W2767925261 hasAuthorship W2767925261A5058401189 @default.
• W2767925261 hasAuthorship W2767925261A5060960849 @default.
• W2767925261 hasAuthorship W2767925261A5071037763 @default.
• W2767925261 hasBestOaLocation W27679252611 @default.
• W2767925261 hasConcept C104317684 @default.
• W2767925261 hasConcept C119056186 @default.
• W2767925261 hasConcept C121608353 @default.
• W2767925261 hasConcept C127561419 @default.
• W2767925261 hasConcept C142724271 @default.
• W2767925261 hasConcept C145059251 @default.
• W2767925261 hasConcept C1491633281 @default.
• W2767925261 hasConcept C2529059 @default.
• W2767925261 hasConcept C2777472916 @default.
• W2767925261 hasConcept C2779013556 @default.
• W2767925261 hasConcept C2781018059 @default.
• W2767925261 hasConcept C2781278892 @default.
• W2767925261 hasConcept C29537977 @default.
• W2767925261 hasConcept C502942594 @default.
• W2767925261 hasConcept C54355233 @default.
• W2767925261 hasConcept C55493867 @default.
• W2767925261 hasConcept C62112901 @default.
• W2767925261 hasConcept C71924100 @default.
• W2767925261 hasConcept C76419328 @default.
• W2767925261 hasConcept C86803240 @default.
• W2767925261 hasConceptScore W2767925261C104317684 @default.
• W2767925261 hasConceptScore W2767925261C119056186 @default.
• W2767925261 hasConceptScore W2767925261C121608353 @default.
• W2767925261 hasConceptScore W2767925261C127561419 @default.
• W2767925261 hasConceptScore W2767925261C142724271 @default.
• W2767925261 hasConceptScore W2767925261C145059251 @default.
• W2767925261 hasConceptScore W2767925261C1491633281 @default.
• W2767925261 hasConceptScore W2767925261C2529059 @default.
• W2767925261 hasConceptScore W2767925261C2777472916 @default.
• W2767925261 hasConceptScore W2767925261C2779013556 @default.
• W2767925261 hasConceptScore W2767925261C2781018059 @default.
• W2767925261 hasConceptScore W2767925261C2781278892 @default.
• W2767925261 hasConceptScore W2767925261C29537977 @default.
• W2767925261 hasConceptScore W2767925261C502942594 @default.
• W2767925261 hasConceptScore W2767925261C54355233 @default.
• W2767925261 hasConceptScore W2767925261C55493867 @default.
• W2767925261 hasConceptScore W2767925261C62112901 @default.
• W2767925261 hasConceptScore W2767925261C71924100 @default.
• W2767925261 hasConceptScore W2767925261C76419328 @default.

• next