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- W2767927579 abstract "SUMMARY. An HPLC method was developed and validated as per ICH guidelines for nicardipine analysis in lipid nanoparticles. Nicardipine was quantified using methanol and 40 mM ammonium formate (pH 3.5) with a ratio 65:35% v/v and BDS C18 column as a stationary phase. Detection of drug was carried out using UV detector at 240 nm by maintaining the flow rate at 1.0 mL/min. Retention time of nicardipine was found to be 4.67 min. Linearity was constructed between 0.50 to 32.00 μg/mL. Percent relative standard deviation (%RSD) from intraday and interday precisions were found to be less than 1% and 2%, respectively.. Nicardipine recovery was found from 93.94 ± 0.51 to 100.16 ± 0.18%. LOD and LOQ values were found to be 25.50 ng/mL and 77.28 ng/mL, respectively. Robustness studies also confirmed that developed method is robust with %RSD < 2%. Study concludes that developed method can be used for analysis of nicardipine in lipid nanoparticles." @default.
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- W2767927579 date "2017-01-01" @default.
- W2767927579 modified "2023-09-27" @default.
- W2767927579 title "Development and validation of an hplc analytical method for the detection and quantification of nicardipine in lipid nanoparticles" @default.
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