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- W2767953804 abstract "Clinical studies in asthma are not able to clear up all aspects of disease pathophysiology. Animal models have been developed to better understand these mechanisms and to evaluate both safety and efficacy of therapies before starting clinical trials. Several species of animals have been used in experimental models of asthma, such as Drosophila, rats, guinea pigs, cats, dogs, pigs, primates and equines. However, the most common species studied in the last two decades is mice, particularly BALB/c. Animal models of asthma try to mimic the pathophysiology of human disease. They classically include two phases: sensitization and challenge. Sensitization is traditionally performed by intraperitoneal and subcutaneous routes, but intranasal instillation of allergens has been increasingly used because human asthma is induced by inhalation of allergens. Challenges with allergens are performed through aerosol, intranasal or intratracheal instillation. However, few studies have compared different routes of sensitization and challenge. The causative allergen is another important issue in developing a good animal model. Despite being more traditional and leading to intense inflammation, ovalbumin has been replaced by aeroallergens, such as house dust mites, to use the allergens that cause human disease. Finally, researchers should define outcomes to be evaluated, such as serum-specific antibodies, airway hyperresponsiveness, inflammation and remodeling. The present review analyzes the animal models of asthma, assessing differences between species, allergens and routes of allergen administration." @default.
- W2767953804 created "2017-11-17" @default.
- W2767953804 creator A5027805334 @default.
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- W2767953804 creator A5065742989 @default.
- W2767953804 date "2017-11-01" @default.
- W2767953804 modified "2023-10-16" @default.
- W2767953804 title "Animal models of asthma: utility and limitations" @default.
- W2767953804 cites W12758477 @default.
- W2767953804 cites W1530405706 @default.
- W2767953804 cites W1545295393 @default.
- W2767953804 cites W1579501226 @default.
- W2767953804 cites W1730980153 @default.
- W2767953804 cites W1766627147 @default.
- W2767953804 cites W1782117688 @default.
- W2767953804 cites W1917987017 @default.
- W2767953804 cites W1952097885 @default.
- W2767953804 cites W1966290524 @default.
- W2767953804 cites W1967399138 @default.
- W2767953804 cites W1972281305 @default.
- W2767953804 cites W1973209812 @default.
- W2767953804 cites W1974954409 @default.
- W2767953804 cites W1980074639 @default.
- W2767953804 cites W1993935898 @default.
- W2767953804 cites W1998508551 @default.
- W2767953804 cites W2006535161 @default.
- W2767953804 cites W2007868832 @default.
- W2767953804 cites W2007949618 @default.
- W2767953804 cites W2008834548 @default.
- W2767953804 cites W2010120074 @default.
- W2767953804 cites W2012269490 @default.
- W2767953804 cites W2013377406 @default.
- W2767953804 cites W2014273697 @default.
- W2767953804 cites W2016383965 @default.
- W2767953804 cites W2019879491 @default.
- W2767953804 cites W2020183630 @default.
- W2767953804 cites W2022590238 @default.
- W2767953804 cites W2024678747 @default.
- W2767953804 cites W2026380193 @default.
- W2767953804 cites W2028190708 @default.
- W2767953804 cites W2028293869 @default.
- W2767953804 cites W2035632341 @default.
- W2767953804 cites W2040845035 @default.
- W2767953804 cites W2044034578 @default.
- W2767953804 cites W2045978898 @default.
- W2767953804 cites W2047720818 @default.
- W2767953804 cites W2047741371 @default.
- W2767953804 cites W2054188263 @default.
- W2767953804 cites W2058411684 @default.
- W2767953804 cites W2060800884 @default.
- W2767953804 cites W2062482845 @default.
- W2767953804 cites W2062485997 @default.
- W2767953804 cites W2062512964 @default.
- W2767953804 cites W2064300792 @default.
- W2767953804 cites W2069528471 @default.
- W2767953804 cites W2078214218 @default.
- W2767953804 cites W2078508636 @default.
- W2767953804 cites W2079617661 @default.
- W2767953804 cites W2087682858 @default.
- W2767953804 cites W2089114061 @default.
- W2767953804 cites W2089831719 @default.
- W2767953804 cites W2102345655 @default.
- W2767953804 cites W2102549002 @default.
- W2767953804 cites W2106980654 @default.
- W2767953804 cites W2108499873 @default.
- W2767953804 cites W2109032237 @default.
- W2767953804 cites W2125596498 @default.
- W2767953804 cites W2128151632 @default.
- W2767953804 cites W2137897978 @default.
- W2767953804 cites W2138426887 @default.
- W2767953804 cites W2140545163 @default.
- W2767953804 cites W2140735852 @default.
- W2767953804 cites W2142495381 @default.
- W2767953804 cites W2145051681 @default.
- W2767953804 cites W2148749694 @default.
- W2767953804 cites W2152652033 @default.
- W2767953804 cites W2155666356 @default.
- W2767953804 cites W2156788680 @default.
- W2767953804 cites W2164352733 @default.
- W2767953804 cites W2168958814 @default.
- W2767953804 cites W2182798394 @default.
- W2767953804 cites W2266150708 @default.
- W2767953804 cites W2271402143 @default.
- W2767953804 cites W2314377370 @default.
- W2767953804 cites W2320164121 @default.
- W2767953804 cites W2387642843 @default.
- W2767953804 cites W2408822614 @default.
- W2767953804 cites W2426638047 @default.
- W2767953804 cites W2437401894 @default.
- W2767953804 cites W2466762991 @default.
- W2767953804 cites W2508311232 @default.
- W2767953804 cites W2517700447 @default.
- W2767953804 cites W2546587539 @default.
- W2767953804 cites W2555121231 @default.
- W2767953804 cites W2588930650 @default.
- W2767953804 cites W2592473061 @default.