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- W2767977912 abstract "Some protein components of intracellular non-membrane-bound entities, such as RNA granules, are known to form hydrogels in vitro. The physico-chemical properties and functional role of these intracellular hydrogels are difficult to study, primarily due to technical challenges in probing these materials in situ. Here, we present iPOLYMER, a strategy for a rapid induction of protein-based hydrogels inside living cells that explores the chemically inducible dimerization paradigm. Biochemical and biophysical characterizations aided by computational modelling show that the polymer network formed in the cytosol resembles a physiological hydrogel-like entity that acts as a size-dependent molecular sieve. We functionalize these polymers with RNA-binding motifs that sequester polyadenine-containing nucleotides to synthetically mimic RNA granules. These results show that iPOLYMER can be used to synthetically reconstitute the nucleation of biologically functional entities, including RNA granules in intact cells." @default.
- W2767977912 created "2017-11-17" @default.
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- W2767977912 date "2017-11-06" @default.
- W2767977912 modified "2023-10-11" @default.
- W2767977912 title "Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions" @default.
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- W2767977912 doi "https://doi.org/10.1038/nmat5006" @default.
- W2767977912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5916848" @default.
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- W2767977912 hasPublicationYear "2017" @default.
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