Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767979087> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2767979087 abstract "Introduction: Randomized trials of left atrial appendage (LAA) closure with the Watchman device have shown disparate results, and its cost-effectiveness compared to anticoagulation has not been evaluated using contemporary data. Methods: We used a Markov decision model to estimate lifetime quality-adjusted survival, costs, and cost-effectiveness of LAA closure with Watchman, compared directly with warfarin and indirectly with dabigatran, using data from the long-term (mean 3.8 year) follow-up of PROTECT AF and PREVAIL randomized trials. Results: Using data from PROTECT AF, the incremental cost-effectiveness ratios (ICER) compared to warfarin and dabigatran were $20,140 and $24,400 per quality adjusted life year (QALY), respectively. Using data from PREVAIL, LAA closure was dominated by warfarin and dabigatran, meaning that it was less effective (9.46, 9.59, and 9.64 QALYs, respectively) and more costly. At a willingness-to-pay-threshold of $50,000 per QALY, LAA closure was cost-effective 62% and 35% of the time under PROTECT AF and PREVAIL assumptions, respectively. These results were sensitive to the rates of ischemic stroke and intracranial hemorrhage for LAA closure and medical anticoagulation. Conclusion: The cost-effectiveness of LAA closure with the Watchman device depends largely on the clinical trial used for assigning event rates. Using data from PROTECT AF, Watchman was cost-effective; using PREVAIL data, Watchman was more costly and less effective than warfarin and dabigatran. Results were highly sensitive to the rates of stroke and intracranial hemorrhage in both treatment groups. Post-marketing surveillance of major adverse events will be vital to determining the value of the Watchman in clinical practice." @default.
- W2767979087 created "2017-11-17" @default.
- W2767979087 creator A5008046120 @default.
- W2767979087 creator A5029193904 @default.
- W2767979087 creator A5029257839 @default.
- W2767979087 creator A5030796795 @default.
- W2767979087 creator A5035376582 @default.
- W2767979087 creator A5045033272 @default.
- W2767979087 creator A5045099759 @default.
- W2767979087 creator A5049163875 @default.
- W2767979087 creator A5049565787 @default.
- W2767979087 creator A5053663571 @default.
- W2767979087 creator A5055079466 @default.
- W2767979087 creator A5090658395 @default.
- W2767979087 date "2015-11-10" @default.
- W2767979087 modified "2023-09-26" @default.
- W2767979087 title "Abstract 16076: Cost-effectiveness of Percutaneous Closure of the Left Atrial Appendage in Atrial Fibrillation Based on Results From PROTECT AF vs. PREVAIL" @default.
- W2767979087 doi "https://doi.org/10.1161/circ.132.suppl_3.16076" @default.
- W2767979087 hasPublicationYear "2015" @default.
- W2767979087 type Work @default.
- W2767979087 sameAs 2767979087 @default.
- W2767979087 citedByCount "0" @default.
- W2767979087 crossrefType "journal-article" @default.
- W2767979087 hasAuthorship W2767979087A5008046120 @default.
- W2767979087 hasAuthorship W2767979087A5029193904 @default.
- W2767979087 hasAuthorship W2767979087A5029257839 @default.
- W2767979087 hasAuthorship W2767979087A5030796795 @default.
- W2767979087 hasAuthorship W2767979087A5035376582 @default.
- W2767979087 hasAuthorship W2767979087A5045033272 @default.
- W2767979087 hasAuthorship W2767979087A5045099759 @default.
- W2767979087 hasAuthorship W2767979087A5049163875 @default.
- W2767979087 hasAuthorship W2767979087A5049565787 @default.
- W2767979087 hasAuthorship W2767979087A5053663571 @default.
- W2767979087 hasAuthorship W2767979087A5055079466 @default.
- W2767979087 hasAuthorship W2767979087A5090658395 @default.
- W2767979087 hasConcept C112930515 @default.
- W2767979087 hasConcept C126322002 @default.
- W2767979087 hasConcept C127413603 @default.
- W2767979087 hasConcept C164705383 @default.
- W2767979087 hasConcept C168563851 @default.
- W2767979087 hasConcept C194828623 @default.
- W2767979087 hasConcept C197934379 @default.
- W2767979087 hasConcept C2776301958 @default.
- W2767979087 hasConcept C2778810321 @default.
- W2767979087 hasConcept C2779161974 @default.
- W2767979087 hasConcept C2780645631 @default.
- W2767979087 hasConcept C2780813298 @default.
- W2767979087 hasConcept C3019080777 @default.
- W2767979087 hasConcept C71924100 @default.
- W2767979087 hasConcept C78519656 @default.
- W2767979087 hasConceptScore W2767979087C112930515 @default.
- W2767979087 hasConceptScore W2767979087C126322002 @default.
- W2767979087 hasConceptScore W2767979087C127413603 @default.
- W2767979087 hasConceptScore W2767979087C164705383 @default.
- W2767979087 hasConceptScore W2767979087C168563851 @default.
- W2767979087 hasConceptScore W2767979087C194828623 @default.
- W2767979087 hasConceptScore W2767979087C197934379 @default.
- W2767979087 hasConceptScore W2767979087C2776301958 @default.
- W2767979087 hasConceptScore W2767979087C2778810321 @default.
- W2767979087 hasConceptScore W2767979087C2779161974 @default.
- W2767979087 hasConceptScore W2767979087C2780645631 @default.
- W2767979087 hasConceptScore W2767979087C2780813298 @default.
- W2767979087 hasConceptScore W2767979087C3019080777 @default.
- W2767979087 hasConceptScore W2767979087C71924100 @default.
- W2767979087 hasConceptScore W2767979087C78519656 @default.
- W2767979087 hasIssue "suppl_3" @default.
- W2767979087 hasLocation W27679790871 @default.
- W2767979087 hasOpenAccess W2767979087 @default.
- W2767979087 hasPrimaryLocation W27679790871 @default.
- W2767979087 hasRelatedWork W1846194700 @default.
- W2767979087 hasRelatedWork W2018617209 @default.
- W2767979087 hasRelatedWork W2022083683 @default.
- W2767979087 hasRelatedWork W2094637221 @default.
- W2767979087 hasRelatedWork W2152949758 @default.
- W2767979087 hasRelatedWork W2164058372 @default.
- W2767979087 hasRelatedWork W2171456024 @default.
- W2767979087 hasRelatedWork W2176270072 @default.
- W2767979087 hasRelatedWork W2279291510 @default.
- W2767979087 hasRelatedWork W2297822100 @default.
- W2767979087 hasRelatedWork W2340043426 @default.
- W2767979087 hasRelatedWork W2367673278 @default.
- W2767979087 hasRelatedWork W2802137927 @default.
- W2767979087 hasRelatedWork W2893559401 @default.
- W2767979087 hasRelatedWork W2987681243 @default.
- W2767979087 hasRelatedWork W3000628610 @default.
- W2767979087 hasRelatedWork W3165990811 @default.
- W2767979087 hasRelatedWork W3212745944 @default.
- W2767979087 hasRelatedWork W2087977409 @default.
- W2767979087 hasRelatedWork W2185470693 @default.
- W2767979087 hasVolume "132" @default.
- W2767979087 isParatext "false" @default.
- W2767979087 isRetracted "false" @default.
- W2767979087 magId "2767979087" @default.
- W2767979087 workType "article" @default.