Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767979983> ?p ?o ?g. }
- W2767979983 endingPage "2983" @default.
- W2767979983 startingPage "2972" @default.
- W2767979983 abstract "Abstract Molecular‐targeted drugs are generally effective against tumors containing driver oncogenes, such as EGFR , ALK , and NTRK 1 . However, patients harboring these oncogenes frequently experience a progression of brain metastases during treatment. Here, we present an in vivo imaging model for brain tumors using human cancer cell lines, including the EGFR ‐L858R/T790M‐positive H1975 lung adenocarcinoma cells, the NUGC 4 hepatocyte growth factor ( HGF )‐dependent gastric cancer cells, and the KM 12 SM colorectal cancer cells containing the TPM 3‐ NTRK 1 gene fusion. We investigated the efficacy of targeted drugs by comparison with their effect in extracranial models. In vitro , H1975 cells were sensitive to the third‐generation epidermal growth factor receptor inhibitor osimertinib. Moreover, HGF stimulated the proliferation of NUGC 4 cells, that was inhibited by crizotinib, which has anti‐ MET activity. KM 12 SM cells were sensitive to the tropomyosin‐related kinase‐A inhibitors crizotinib and entrectinib. In in vivo H1975 cell models, osimertinib inhibited the progression of both brain and subcutaneous tumors. Furthermore, in in vivo NUGC 4 cell models, crizotinib remarkably delayed the progression of brain tumors, and that of peritoneal carcinomatosis. Interestingly, in in vivo KM 12 SM cell models, treatment with crizotinib delayed the progression of liver metastases, but not that of brain tumors. Conversely, treatment with entrectinib discernibly delayed the progression of both tumor types. Thus, the effect of targeted drugs against brain tumors can differ from the one reported in extracranial tumors. Moreover, the same multikinase inhibitory drug can display different efficacies in brain tumor models containing different drivers. Therefore, our in vivo imaging model for brain tumors may prove useful for preclinical drug screening against brain metastases." @default.
- W2767979983 created "2017-11-17" @default.
- W2767979983 creator A5004483141 @default.
- W2767979983 creator A5008116561 @default.
- W2767979983 creator A5011349417 @default.
- W2767979983 creator A5017882443 @default.
- W2767979983 creator A5018773565 @default.
- W2767979983 creator A5027301255 @default.
- W2767979983 creator A5033740484 @default.
- W2767979983 creator A5034402540 @default.
- W2767979983 creator A5034771136 @default.
- W2767979983 creator A5039034876 @default.
- W2767979983 creator A5045660079 @default.
- W2767979983 creator A5060520190 @default.
- W2767979983 creator A5081262580 @default.
- W2767979983 creator A5086218839 @default.
- W2767979983 creator A5090785872 @default.
- W2767979983 date "2017-11-10" @default.
- W2767979983 modified "2023-10-01" @default.
- W2767979983 title "<i>In vivo</i>imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs" @default.
- W2767979983 cites W1832172388 @default.
- W2767979983 cites W1902158572 @default.
- W2767979983 cites W1975784282 @default.
- W2767979983 cites W1979188008 @default.
- W2767979983 cites W1986268367 @default.
- W2767979983 cites W1992303404 @default.
- W2767979983 cites W1997601288 @default.
- W2767979983 cites W2002428607 @default.
- W2767979983 cites W2003587204 @default.
- W2767979983 cites W2011670622 @default.
- W2767979983 cites W2042902581 @default.
- W2767979983 cites W2051009495 @default.
- W2767979983 cites W2062556853 @default.
- W2767979983 cites W2064378491 @default.
- W2767979983 cites W2066454038 @default.
- W2767979983 cites W2091618582 @default.
- W2767979983 cites W2096786080 @default.
- W2767979983 cites W2102339709 @default.
- W2767979983 cites W2111254482 @default.
- W2767979983 cites W2115549126 @default.
- W2767979983 cites W2125195105 @default.
- W2767979983 cites W2135212506 @default.
- W2767979983 cites W2139027674 @default.
- W2767979983 cites W2141042450 @default.
- W2767979983 cites W2143859186 @default.
- W2767979983 cites W2145618171 @default.
- W2767979983 cites W2147038864 @default.
- W2767979983 cites W2148613928 @default.
- W2767979983 cites W2158789700 @default.
- W2767979983 cites W2159821105 @default.
- W2767979983 cites W2170810978 @default.
- W2767979983 cites W2174684187 @default.
- W2767979983 cites W2180425334 @default.
- W2767979983 cites W2225079860 @default.
- W2767979983 cites W2257614390 @default.
- W2767979983 cites W2397413571 @default.
- W2767979983 cites W2494292000 @default.
- W2767979983 cites W2546236621 @default.
- W2767979983 cites W2576107450 @default.
- W2767979983 cites W2581545819 @default.
- W2767979983 cites W2586643535 @default.
- W2767979983 cites W2586704604 @default.
- W2767979983 cites W2591118779 @default.
- W2767979983 cites W2753824910 @default.
- W2767979983 doi "https://doi.org/10.1002/cam4.1255" @default.
- W2767979983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5727243" @default.
- W2767979983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29125233" @default.
- W2767979983 hasPublicationYear "2017" @default.
- W2767979983 type Work @default.
- W2767979983 sameAs 2767979983 @default.
- W2767979983 citedByCount "1" @default.
- W2767979983 countsByYear W27679799832023 @default.
- W2767979983 crossrefType "journal-article" @default.
- W2767979983 hasAuthorship W2767979983A5004483141 @default.
- W2767979983 hasAuthorship W2767979983A5008116561 @default.
- W2767979983 hasAuthorship W2767979983A5011349417 @default.
- W2767979983 hasAuthorship W2767979983A5017882443 @default.
- W2767979983 hasAuthorship W2767979983A5018773565 @default.
- W2767979983 hasAuthorship W2767979983A5027301255 @default.
- W2767979983 hasAuthorship W2767979983A5033740484 @default.
- W2767979983 hasAuthorship W2767979983A5034402540 @default.
- W2767979983 hasAuthorship W2767979983A5034771136 @default.
- W2767979983 hasAuthorship W2767979983A5039034876 @default.
- W2767979983 hasAuthorship W2767979983A5045660079 @default.
- W2767979983 hasAuthorship W2767979983A5060520190 @default.
- W2767979983 hasAuthorship W2767979983A5081262580 @default.
- W2767979983 hasAuthorship W2767979983A5086218839 @default.
- W2767979983 hasAuthorship W2767979983A5090785872 @default.
- W2767979983 hasBestOaLocation W27679799831 @default.
- W2767979983 hasConcept C121608353 @default.
- W2767979983 hasConcept C126322002 @default.
- W2767979983 hasConcept C142724271 @default.
- W2767979983 hasConcept C150903083 @default.
- W2767979983 hasConcept C170493617 @default.
- W2767979983 hasConcept C207001950 @default.
- W2767979983 hasConcept C2776232967 @default.
- W2767979983 hasConcept C2776256026 @default.
- W2767979983 hasConcept C2776996007 @default.