FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767986344> ?p ?o ?g. }

• W2767986344 endingPage "2217" @default.
• W2767986344 startingPage "2209" @default.
• W2767986344 abstract "Cadmium (Cd) is an environmental electrophile that modifies protein nucleophiles, thereby modulating cellular signaling and toxicity. While reactive persulfides/polysulfides exhibit relatively high nucleophilic properties, their roles in the altered gene expression and toxicity caused by Cd remain unclear. Exposing primary mouse hepatocytes to Cd caused heat shock protein 70 (HSP70) and metallothionein (MT)-I/II to be upregulated and cytotoxicity to occur. These effects were blocked in the presence of polysulfide sodium tetrasulfide (Na2S4). Electrospray ionization mass spectrometry analysis indicated that cadmium sulfide (CdS) and cadmium thiosulfate (CdS2O3) were produced when Cd reacted with Na2S4. Authentic CdS did not cause cellular signaling responses to be activated or hepatotoxic effects, while CdS2O3 had effects similar to those of Cd. HSP70 and MT-I/II upregulation and hepatotoxicity caused by exposure to Cd were significantly enhanced by the deletion of cystathionine γ-lyase (CSE), which catalyzes the formation of reactive persulfides/polysulfides. Deleting CSE also exacerbated Cd-mediated liver injury, whereas little hepatic damage was found when CdS or Na2S4 along with Cd was administered. Overall, the results suggest that the persulfide/polysulfide-mediated formation of sulfur adducts of Cd such as CdS rather than CdS2O3 is, at least in part, involved in decreasing the level of Cd-mediated activation of cellular signaling and toxicity." @default.
• W2767986344 created "2017-11-17" @default.
• W2767986344 creator A5004496411 @default.
• W2767986344 creator A5013567557 @default.
• W2767986344 creator A5051046396 @default.
• W2767986344 creator A5053538042 @default.
• W2767986344 creator A5054996924 @default.
• W2767986344 creator A5064323546 @default.
• W2767986344 date "2017-11-20" @default.
• W2767986344 modified "2023-10-16" @default.
• W2767986344 title "The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity" @default.
• W2767986344 cites W118580408 @default.
• W2767986344 cites W1508957332 @default.
• W2767986344 cites W1568628619 @default.
• W2767986344 cites W1629179716 @default.
• W2767986344 cites W1960489659 @default.
• W2767986344 cites W1971499116 @default.
• W2767986344 cites W1974516883 @default.
• W2767986344 cites W1980620688 @default.
• W2767986344 cites W1982693949 @default.
• W2767986344 cites W1987106543 @default.
• W2767986344 cites W1990208536 @default.
• W2767986344 cites W1991535520 @default.
• W2767986344 cites W1994318446 @default.
• W2767986344 cites W1994352328 @default.
• W2767986344 cites W1997728584 @default.
• W2767986344 cites W1999323277 @default.
• W2767986344 cites W2003001134 @default.
• W2767986344 cites W2003197024 @default.
• W2767986344 cites W2003861270 @default.
• W2767986344 cites W2005259180 @default.
• W2767986344 cites W2009339389 @default.
• W2767986344 cites W2012498400 @default.
• W2767986344 cites W2016074938 @default.
• W2767986344 cites W2017521727 @default.
• W2767986344 cites W2017820330 @default.
• W2767986344 cites W2021998251 @default.
• W2767986344 cites W2035718449 @default.
• W2767986344 cites W2059726151 @default.
• W2767986344 cites W2065504621 @default.
• W2767986344 cites W2067148630 @default.
• W2767986344 cites W2068679151 @default.
• W2767986344 cites W2072613715 @default.
• W2767986344 cites W2076436529 @default.
• W2767986344 cites W2078295255 @default.
• W2767986344 cites W2080720034 @default.
• W2767986344 cites W2086809297 @default.
• W2767986344 cites W2090745019 @default.
• W2767986344 cites W2095151229 @default.
• W2767986344 cites W2121428338 @default.
• W2767986344 cites W2145180842 @default.
• W2767986344 cites W2162645036 @default.
• W2767986344 cites W2195785268 @default.
• W2767986344 cites W2289524523 @default.
• W2767986344 cites W2292175535 @default.
• W2767986344 cites W2314919359 @default.
• W2767986344 cites W2325186294 @default.
• W2767986344 cites W2329862184 @default.
• W2767986344 cites W2405848654 @default.
• W2767986344 cites W2408280346 @default.
• W2767986344 cites W2468985033 @default.
• W2767986344 cites W2558435853 @default.
• W2767986344 cites W2566749193 @default.
• W2767986344 cites W2580968599 @default.
• W2767986344 cites W2731784296 @default.
• W2767986344 cites W4382022984 @default.
• W2767986344 doi "https://doi.org/10.1021/acs.chemrestox.7b00278" @default.
• W2767986344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29116755" @default.
• W2767986344 hasPublicationYear "2017" @default.
• W2767986344 type Work @default.
• W2767986344 sameAs 2767986344 @default.
• W2767986344 citedByCount "29" @default.
• W2767986344 countsByYear W27679863442018 @default.
• W2767986344 countsByYear W27679863442019 @default.
• W2767986344 countsByYear W27679863442020 @default.
• W2767986344 countsByYear W27679863442021 @default.
• W2767986344 countsByYear W27679863442022 @default.
• W2767986344 countsByYear W27679863442023 @default.
• W2767986344 crossrefType "journal-article" @default.
• W2767986344 hasAuthorship W2767986344A5004496411 @default.
• W2767986344 hasAuthorship W2767986344A5013567557 @default.
• W2767986344 hasAuthorship W2767986344A5051046396 @default.
• W2767986344 hasAuthorship W2767986344A5053538042 @default.
• W2767986344 hasAuthorship W2767986344A5054996924 @default.
• W2767986344 hasAuthorship W2767986344A5064323546 @default.
• W2767986344 hasConcept C104317684 @default.
• W2767986344 hasConcept C109316439 @default.
• W2767986344 hasConcept C127561419 @default.
• W2767986344 hasConcept C147789679 @default.
• W2767986344 hasConcept C17525397 @default.
• W2767986344 hasConcept C178790620 @default.
• W2767986344 hasConcept C179104552 @default.
• W2767986344 hasConcept C181199279 @default.
• W2767986344 hasConcept C185592680 @default.
• W2767986344 hasConcept C202751555 @default.
• W2767986344 hasConcept C205260736 @default.
• W2767986344 hasConcept C20719415 @default.
• W2767986344 hasConcept C2777379467 @default.

• next